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- W2895814998 abstract "When performing volume-based analysis on structural MRI data, it is necessary to normalize the structure volume with respect to the total intracranial volume (TIV) to account for the gross head size difference. Accurate TIV estimation is therefore crucial. Previously clinical MRI practice with scanners of 1.5 Tesla (T) field strength has been shifting to 3T. It is important to evaluate the effect of the resulted image difference towards the TIV estimation, as well as the consequent longitudinal data analysis of disease-specific structural biomarker such as hippocampal atrophy. In this paper, we studied the intracranial volume estimation of images acquired for the same patients with both 1.5T and 3T scanner. Longitudinal data (up to 36 months) from 187 subjects were obtained from Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort. The longitudinal robustness of TIV estimation on both field strength were evaluated using three state-of-the-art methods: FreeSurfer 6.0, SPM12 and multi-atlas label fusion (MALF) based on non-rigid registration. We also assessed the effect of field strength towards hippocampal atrophy over time with TIV normalization. All three methods showed reliable longitudinal estimation of TIV for both field strength, with 3T TIV consistently smaller than the corresponding 1.5T counterpart. 3T data also showed smaller grey matter, larger white matter, and larger ventricle. In addition, 3D data revealed marginal gain of statistical power when detected longitudinal hippocampal atrophy rate between cognitive normal group(CN) and mild cognitive impaired (both stable-MCI and progressive-MCI) group compared to the 1.5T data. TIV normalization does not alter the statistical analysis for data of both field strengths." @default.
- W2895814998 created "2018-10-26" @default.
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- W2895814998 date "2018-07-01" @default.
- W2895814998 modified "2023-10-16" @default.
- W2895814998 title "P3‐405: THE EFFECT OF FIELD STRENGTH TOWARD LONGITUDINAL TOTAL INTRACRANIAL VOLUME ESTIMATION AND HIPPOCAMPAL ATROPHY ON ADNI DATA" @default.
- W2895814998 doi "https://doi.org/10.1016/j.jalz.2018.06.1768" @default.
- W2895814998 hasPublicationYear "2018" @default.
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