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• W2895815928 abstract "Febrile symptoms in children are a leading cause of health-care seeking behaviour worldwide. The majority of febrile illnesses are uncomplicated and self-limited, without the need for referral or hospital admission. However, current diagnostic tools are unable to identify which febrile children have self-limited infection and which children are at risk of progressing to life-threatening infections, such as severe malaria. This paper describes the need for a simple community-based tool that can improve the early recognition and triage of febrile children, with either malarial or non-malarial illness, at risk of critical illness. The integration of a disease severity marker into existing malaria rapid diagnostic tests (RDT) could enable detection of children at risk of severe infection in the hospital and community, irrespective of aetiology. Incorporation of a disease severity marker could inform individualized management and early triage of children at risk of life-threatening infection. A child positive for both malaria and a disease severity marker could be prioritized for urgent referral/admission and parenteral therapy. A child positive for malaria and negative for a disease severity marker could be managed conservatively, as an out-patient, with oral anti-malarial therapy. An RDT with a disease severity marker could facilitate an integrated community-based approach to fever syndromes and improve early recognition, risk stratification, and prompt treatment of severe malaria and other life-threatening infections." @default.
• W2895815928 created "2018-10-26" @default.
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• W2895815928 date "2018-10-10" @default.
• W2895815928 modified "2023-10-12" @default.
• W2895815928 title "Integrated fever management: disease severity markers to triage children with malaria and non-malarial febrile illness" @default.
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• W2895815928 doi "https://doi.org/10.1186/s12936-018-2488-x" @default.
• W2895815928 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6180660" @default.
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• W2895815928 hasPublicationYear "2018" @default.
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