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- W2895819752 abstract "Abstract Diabetic nephropathy ( DN ) is one of general and common complication of diabetes, which severely affects the physical and mental health of diabetic patients. Fibroblast growth factor 1 ( FGF 1), an effective control agent of blood glucose, plays an effective treatment role on diabetes‐induced renal injury. But the specific molecule mechanism underlying it is still unclear. Since induction of cellular stress is the main and common mechanism of diabetes‐induced complication, we hypothesized that reduction of cellular stress is also the molecular mechanism of FGF 1 treatment for DN . Here, we have further confirmed that FGF 1 significantly ameliorated the diabetes‐induced renal interstitial fibrosis and glomerular damage. The expression levels of collagen and α‐smooth muscle actin (α‐ SMA ) also dramatically induced in kidney from db/db mice, but these effects were blocked by FGF 1 administration. Our mechanistic investigation had further revealed that diabetes significantly induced oxidative stress, nitrosative stress, and endoplasmic reticulum ( ER ) stress with upregulation of malondialdehyde ( MDA ), nitrotyrosine level, ER stress makers and downregulation of antioxidant capacity ( AOC ). FGF 1 treatment significantly attenuated the effect of diabetes on cellular stress. We conclude that FGF 1‐associated glucose decreases and subsequent reduction of cellular stress is the another potential molecule mechanism underlying FGF 1 treatment for DN ." @default.
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- W2895819752 date "2018-10-15" @default.
- W2895819752 modified "2023-09-29" @default.
- W2895819752 title "Reduction of cellular stress is essential for Fibroblast growth factor 1 treatment for diabetic nephropathy" @default.
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- W2895819752 doi "https://doi.org/10.1111/jcmm.13921" @default.
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