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- W2895820840 abstract "To examine whether commonly used first trimester screening markers differ in patients who have a subsequent positive amniotic fluid PCR culture for CMV following a first trimester maternal CMV seroconversion. This is a retrospective cohort study analysing patients who attended our unit from 2009 to 2017 with a first trimester maternal CMV seroconversion. The cases were retrieved from our ultrasound database and medical records. First trimester screening markers BhCG and PAPP- A MoMs and uterine artery Doppler PI were extracted from the relevant patient cases. All patients had a subsequent amniocentesis to illicit whether vertical transmission of the CMV virus had occurred. The means of the first trimester markers were compared between those who had a positive amniotic fluid PCR for CMV with those with a negative amniocentesis. First trimester maternal biochemical markers BhCG and PAPP-A were available for 146 and 149 patients respectively during the study period. Uterine artery Doppler PI measurements were available for 67 patients. The median MoM for BhCG was 0.97 and 0.94 for PAPP-A. There were 100 cases in the amnio negative group for BhCG and 46 cases with a positive culture. 102 cases were available for PAPP-A with a negative amniocentesis and 46 with a positive result. The biomarkers were converted to log10 values to obtain a normal gaussian distribution. An independent t-test was used to compare the means of the biomarkers between those with a positive amniocentesis with those with a negative CMV amniotic fluid culture. There was no significant difference between the groups in all 3 categories; BhCG MoM (p=0.819), PAPP-A MoM (p=0.888), and UtPI (p=0.289). In women who undergo a CMV seroconversion in the first trimester of pregnancy, there is no discrepancy in the first trimester biomarkers that can be associated with vertical transmission." @default.
- W2895820840 created "2018-10-26" @default.
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- W2895820840 date "2018-10-01" @default.
- W2895820840 modified "2023-10-03" @default.
- W2895820840 title "OP09.07: First trimester biochemical and biophysical markers in patients with a first trimester CMV seroconversion" @default.
- W2895820840 doi "https://doi.org/10.1002/uog.19469" @default.
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