FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895822332> ?p ?o ?g. }

• W2895822332 abstract "Abstract SWI/SNF or BAF chromatin-remodeling complexes are polymorphic assemblies of homologous subunit families that remodel nucleosomes and facilitate tissue-specific gene regulation during development. BAF57/SMARCE1 is a BAF complex subunit encoded in animals by a single gene and is a component of all mammalian BAF complexes. In vivo , the loss of SMARCE1 would lead to the formation of deficient combinations of the complex which might present limited remodeling activities. To address the specific contribution of SMARCE1 to the function of the BAF complex, we generated CRISPR/Cas9 mutations of smarce1 in zebrafish. Smarce1 mutants showed visible defects at 72 hpf, including smaller eyes, abnormal body curvature and heart abnormalities. Gene expression analysis revealed that the mutant embryos displayed defects in endocardial development since early stages, which led to the formation of a misshapen heart tube. The severe morphological and functional cardiac problems observed at 4 dpf were correlated with the substantially increased expression of different cardiac transcription factors. Additionally, we showed that Smarce1 binds to cis-regulatory regions of the gata5 gene and is necessary for the recruitment of the BAF complex to these regions." @default.
• W2895822332 created "2018-10-26" @default.
• W2895822332 creator A5001921078 @default.
• W2895822332 creator A5035458333 @default.
• W2895822332 creator A5068371729 @default.
• W2895822332 creator A5079226834 @default.
• W2895822332 date "2018-10-18" @default.
• W2895822332 modified "2023-10-02" @default.
• W2895822332 title "smarce1 mutants have a defective endocardium and an increased expression of cardiac transcription factors in zebrafish" @default.
• W2895822332 cites W1656220430 @default.
• W2895822332 cites W1863364305 @default.
• W2895822332 cites W1873397816 @default.
• W2895822332 cites W1934669271 @default.
• W2895822332 cites W1963506471 @default.
• W2895822332 cites W1967622017 @default.
• W2895822332 cites W1968550540 @default.
• W2895822332 cites W1970219055 @default.
• W2895822332 cites W1973604405 @default.
• W2895822332 cites W1976391205 @default.
• W2895822332 cites W1980881029 @default.
• W2895822332 cites W1987287311 @default.
• W2895822332 cites W1989312217 @default.
• W2895822332 cites W1989642526 @default.
• W2895822332 cites W1991626728 @default.
• W2895822332 cites W2005926910 @default.
• W2895822332 cites W2012177247 @default.
• W2895822332 cites W2017224987 @default.
• W2895822332 cites W2023942843 @default.
• W2895822332 cites W2024353183 @default.
• W2895822332 cites W2031496441 @default.
• W2895822332 cites W2043744435 @default.
• W2895822332 cites W2050388131 @default.
• W2895822332 cites W2051037582 @default.
• W2895822332 cites W2053188090 @default.
• W2895822332 cites W2053348556 @default.
• W2895822332 cites W2055124799 @default.
• W2895822332 cites W2062405135 @default.
• W2895822332 cites W2072547562 @default.
• W2895822332 cites W2078348074 @default.
• W2895822332 cites W2080571195 @default.
• W2895822332 cites W2083203432 @default.
• W2895822332 cites W2090913994 @default.
• W2895822332 cites W2094651478 @default.
• W2895822332 cites W2100600401 @default.
• W2895822332 cites W2103968215 @default.
• W2895822332 cites W2103991023 @default.
• W2895822332 cites W2106578635 @default.
• W2895822332 cites W2114430445 @default.
• W2895822332 cites W2124752518 @default.
• W2895822332 cites W2124971764 @default.
• W2895822332 cites W2125349610 @default.
• W2895822332 cites W2128103215 @default.
• W2895822332 cites W2135035484 @default.
• W2895822332 cites W2136623079 @default.
• W2895822332 cites W2138248682 @default.
• W2895822332 cites W2146927398 @default.
• W2895822332 cites W2150407460 @default.
• W2895822332 cites W2153466675 @default.
• W2895822332 cites W2160577043 @default.
• W2895822332 cites W2162047645 @default.
• W2895822332 cites W2285741280 @default.
• W2895822332 cites W2347033096 @default.
• W2895822332 cites W56074328 @default.
• W2895822332 cites W64143956 @default.
• W2895822332 doi "https://doi.org/10.1038/s41598-018-33746-8" @default.
• W2895822332 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6194089" @default.
• W2895822332 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30337622" @default.
• W2895822332 hasPublicationYear "2018" @default.
• W2895822332 type Work @default.
• W2895822332 sameAs 2895822332 @default.
• W2895822332 citedByCount "9" @default.
• W2895822332 countsByYear W28958223322019 @default.
• W2895822332 countsByYear W28958223322021 @default.
• W2895822332 countsByYear W28958223322022 @default.
• W2895822332 countsByYear W28958223322023 @default.
• W2895822332 crossrefType "journal-article" @default.
• W2895822332 hasAuthorship W2895822332A5001921078 @default.
• W2895822332 hasAuthorship W2895822332A5035458333 @default.
• W2895822332 hasAuthorship W2895822332A5068371729 @default.
• W2895822332 hasAuthorship W2895822332A5079226834 @default.
• W2895822332 hasBestOaLocation W28958223321 @default.
• W2895822332 hasConcept C104292427 @default.
• W2895822332 hasConcept C104317684 @default.
• W2895822332 hasConcept C126322002 @default.
• W2895822332 hasConcept C138885662 @default.
• W2895822332 hasConcept C143065580 @default.
• W2895822332 hasConcept C145103041 @default.
• W2895822332 hasConcept C150194340 @default.
• W2895822332 hasConcept C165864922 @default.
• W2895822332 hasConcept C167227067 @default.
• W2895822332 hasConcept C179926584 @default.
• W2895822332 hasConcept C2776878037 @default.
• W2895822332 hasConcept C41895202 @default.
• W2895822332 hasConcept C54355233 @default.
• W2895822332 hasConcept C62425271 @default.
• W2895822332 hasConcept C71924100 @default.
• W2895822332 hasConcept C83640560 @default.
• W2895822332 hasConcept C85378888 @default.
• W2895822332 hasConcept C86339819 @default.
• W2895822332 hasConcept C86803240 @default.

• next