FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895825499> ?p ?o ?g. }

• W2895825499 abstract "Giant viruses of amoebae were discovered in 2003. Since then, their diversity has greatly expanded. They were suggested to form a fourth branch of life, collectively named ‘TRUC’ (for “Things Resisting Uncompleted Classifications”) alongside Bacteria, Archaea and Eukarya. Their origin and ancestrality remain controversial. Here, we specify the evolution and definition of giant viruses. Phylogenetic and phenetic analyses of informational gene repertoires of giant viruses and selected bacteria, archaea and eukaryota were performed, including structural phylogenomics based on protein structural domains grouped into 289 universal fold superfamilies (FSFs). Hierarchical clustering analysis was performed based on a binary presence/absence matrix constructed using 727 informational COGs from cellular organisms. The presence/absence of ‘universal’ FSF domains was used to generate an unrooted maximum parsimony phylogenomic tree. Comparison of the gene content of a giant virus with those of a bacterium, an archaeon, and a eukaryote with small genomes was also performed. Overall, both cladistic analyses based on gene sequences of very central and ancient proteins and on highly conserved protein fold structures as well as phenetic analyses were congruent regarding the delineation of a fourth branch of microbes comprised by giant viruses. Giant viruses appeared as a basal group in the tree of all proteomes. A pangenome and core genome determined for Rickettsia bellii (bacteria), Methanomassillicoccus luminyensis (archaeon), Encephalitozoon intestinalis (eukaryote), and Tupanvirus (giant virus) showed a substantial proportion of Tupanvirus genes that overlap with those of the cellular microbes. In addition, a substantial genome mosaicism was observed, with 51%, 11%, 8% and 0.2% of Tupanvirus genes best matching with viruses, eukaryota, bacteria and archaea, respectively. Finally, we found that genes themselves may be subject to lateral sequence transfers. In summary, our data highlight the quantum leap between classical and giant viruses. Phylogenetic and phyletic analyses and the study of protein fold superfamilies confirm previous evidence of the existence of a fourth TRUC of life that includes giant viruses, and highlight its ancestrality and mosaicism. They also point out that best evolutionary representations for giant viruses and cellular microorganisms are rhizomes, and that sequence transfers rather than gene transfers have to be considered." @default.
• W2895825499 created "2018-10-26" @default.
• W2895825499 creator A5023619971 @default.
• W2895825499 creator A5024401591 @default.
• W2895825499 creator A5026404241 @default.
• W2895825499 creator A5046843019 @default.
• W2895825499 creator A5056663199 @default.
• W2895825499 creator A5067647822 @default.
• W2895825499 creator A5074730004 @default.
• W2895825499 creator A5079455771 @default.
• W2895825499 date "2018-11-27" @default.
• W2895825499 modified "2023-10-15" @default.
• W2895825499 title "Ancestrality and Mosaicism of Giant Viruses Supporting the Definition of the Fourth TRUC of Microbes" @default.
• W2895825499 cites W1515844392 @default.
• W2895825499 cites W1569372935 @default.
• W2895825499 cites W1574037146 @default.
• W2895825499 cites W1872263111 @default.
• W2895825499 cites W1957297818 @default.
• W2895825499 cites W1965770763 @default.
• W2895825499 cites W1970256781 @default.
• W2895825499 cites W1974133438 @default.
• W2895825499 cites W1979835060 @default.
• W2895825499 cites W1981435058 @default.
• W2895825499 cites W1981729880 @default.
• W2895825499 cites W1982807864 @default.
• W2895825499 cites W1986218151 @default.
• W2895825499 cites W1988165232 @default.
• W2895825499 cites W1988640124 @default.
• W2895825499 cites W1989426516 @default.
• W2895825499 cites W1990268869 @default.
• W2895825499 cites W1991823556 @default.
• W2895825499 cites W2001638179 @default.
• W2895825499 cites W2003799941 @default.
• W2895825499 cites W2005818475 @default.
• W2895825499 cites W2007093279 @default.
• W2895825499 cites W2007786086 @default.
• W2895825499 cites W2008856488 @default.
• W2895825499 cites W2011321416 @default.
• W2895825499 cites W2011617240 @default.
• W2895825499 cites W2013710543 @default.
• W2895825499 cites W2015912343 @default.
• W2895825499 cites W2026029387 @default.
• W2895825499 cites W2031611770 @default.
• W2895825499 cites W2031742656 @default.
• W2895825499 cites W2032128976 @default.
• W2895825499 cites W2038887742 @default.
• W2895825499 cites W2039659321 @default.
• W2895825499 cites W2043499324 @default.
• W2895825499 cites W2044370951 @default.
• W2895825499 cites W2044374033 @default.
• W2895825499 cites W2046195371 @default.
• W2895825499 cites W2050223484 @default.
• W2895825499 cites W2055043387 @default.
• W2895825499 cites W2063872287 @default.
• W2895825499 cites W2065506174 @default.
• W2895825499 cites W2066261007 @default.
• W2895825499 cites W2071026657 @default.
• W2895825499 cites W2071642194 @default.
• W2895825499 cites W2074248513 @default.
• W2895825499 cites W2078570318 @default.
• W2895825499 cites W2080229897 @default.
• W2895825499 cites W2085416473 @default.
• W2895825499 cites W2088934822 @default.
• W2895825499 cites W2090408264 @default.
• W2895825499 cites W2097002638 @default.
• W2895825499 cites W2097270746 @default.
• W2895825499 cites W2099946731 @default.
• W2895825499 cites W2103536483 @default.
• W2895825499 cites W2104057378 @default.
• W2895825499 cites W2107912813 @default.
• W2895825499 cites W2109721582 @default.
• W2895825499 cites W2113878642 @default.
• W2895825499 cites W2115138247 @default.
• W2895825499 cites W2117500540 @default.
• W2895825499 cites W2118290874 @default.
• W2895825499 cites W2120442640 @default.
• W2895825499 cites W2124669617 @default.
• W2895825499 cites W2128653811 @default.
• W2895825499 cites W2131527832 @default.
• W2895825499 cites W2132926880 @default.
• W2895825499 cites W2135538129 @default.
• W2895825499 cites W2136385462 @default.
• W2895825499 cites W2139060548 @default.
• W2895825499 cites W2140411408 @default.
• W2895825499 cites W2146070647 @default.
• W2895825499 cites W2146536773 @default.
• W2895825499 cites W2149106578 @default.
• W2895825499 cites W2153452535 @default.
• W2895825499 cites W2155277761 @default.
• W2895825499 cites W2155479257 @default.
• W2895825499 cites W2157321139 @default.
• W2895825499 cites W2165659155 @default.
• W2895825499 cites W2166111787 @default.
• W2895825499 cites W2171366861 @default.
• W2895825499 cites W2211953232 @default.
• W2895825499 cites W2220101274 @default.
• W2895825499 cites W2230986005 @default.
• W2895825499 cites W2254775448 @default.
• W2895825499 cites W2256933318 @default.
• W2895825499 cites W2262421663 @default.

• next