Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895829056> ?p ?o ?g. }
- W2895829056 abstract "Abstract From the schizophrenia drug-target interactome, 1 we studied the drugs that targeted multiple proteins in the interactome, or those that target proteins with many targets, or those that target novel (computationally predicted) interactors of schizophrenia associated proteins. In schizophrenia, gene expression has been described as a measurable aspect of the disease reflecting the action of risk genes. We studied each of the selected drugs using the NextBio software suite, and shortlisted those that had a negative correlation with gene expression of schizophrenia. This analysis resulted in 12 drugs whose differential gene expression (drug versus normal) had an anti-correlation with differential expression for schizophrenia (disorder versus normal). Some of these drugs were already being tested for their clinical activity in schizophrenia and other neuropsychiatric disorders. Several proteins in the protein interactome of the targets of several of these drugs were associated with various neuropsychiatric disorders. The network of genes which were differentially expressed on drug treatment, and had an anti-correlation with gene expression in schizophrenia, were significantly enriched in pathways relevant to schizophrenia etiology and GWAS genes associated with traits or diseases that had pathophysiological overlap with schizophrenia. Drugs that are structurally similar to the shortlisted drugs, or targeted the same genes as these drugs, have also demonstrated clinical activity in schizophrenia and other related disorders. This integrated computational analysis may help translate insights from the schizophrenia drug-protein interactome to clinical research - an important step, especially in the field of psychiatric drug development, facing a high failure rate." @default.
- W2895829056 created "2018-10-26" @default.
- W2895829056 creator A5000049528 @default.
- W2895829056 creator A5018747166 @default.
- W2895829056 creator A5066367676 @default.
- W2895829056 date "2018-10-13" @default.
- W2895829056 modified "2023-09-27" @default.
- W2895829056 title "Potentially repurposable drugs for schizophrenia identified from its interactome" @default.
- W2895829056 cites W153750880 @default.
- W2895829056 cites W1963539042 @default.
- W2895829056 cites W1966702657 @default.
- W2895829056 cites W1966935424 @default.
- W2895829056 cites W1970385549 @default.
- W2895829056 cites W1971680080 @default.
- W2895829056 cites W1973141868 @default.
- W2895829056 cites W1973717649 @default.
- W2895829056 cites W1975493924 @default.
- W2895829056 cites W1979519830 @default.
- W2895829056 cites W1980379187 @default.
- W2895829056 cites W1980657678 @default.
- W2895829056 cites W1982430777 @default.
- W2895829056 cites W1984997243 @default.
- W2895829056 cites W1987942611 @default.
- W2895829056 cites W1993753481 @default.
- W2895829056 cites W1998675403 @default.
- W2895829056 cites W2000030766 @default.
- W2895829056 cites W2003261794 @default.
- W2895829056 cites W2005528706 @default.
- W2895829056 cites W2006135699 @default.
- W2895829056 cites W2017384269 @default.
- W2895829056 cites W2022432195 @default.
- W2895829056 cites W2026967508 @default.
- W2895829056 cites W2027316175 @default.
- W2895829056 cites W2027550306 @default.
- W2895829056 cites W2029988825 @default.
- W2895829056 cites W2030222772 @default.
- W2895829056 cites W2032288122 @default.
- W2895829056 cites W2037921296 @default.
- W2895829056 cites W2040607104 @default.
- W2895829056 cites W2041409401 @default.
- W2895829056 cites W2043084931 @default.
- W2895829056 cites W2046998739 @default.
- W2895829056 cites W2049108687 @default.
- W2895829056 cites W2050074228 @default.
- W2895829056 cites W2055586221 @default.
- W2895829056 cites W2063055877 @default.
- W2895829056 cites W2068164341 @default.
- W2895829056 cites W2068815274 @default.
- W2895829056 cites W2069779039 @default.
- W2895829056 cites W2070664595 @default.
- W2895829056 cites W2074280516 @default.
- W2895829056 cites W2076764146 @default.
- W2895829056 cites W2076940041 @default.
- W2895829056 cites W2080248624 @default.
- W2895829056 cites W2087337863 @default.
- W2895829056 cites W2087798692 @default.
- W2895829056 cites W2091960711 @default.
- W2895829056 cites W2095440873 @default.
- W2895829056 cites W2098346855 @default.
- W2895829056 cites W2100606330 @default.
- W2895829056 cites W2101357408 @default.
- W2895829056 cites W2104385821 @default.
- W2895829056 cites W2105962778 @default.
- W2895829056 cites W2112488255 @default.
- W2895829056 cites W2113672425 @default.
- W2895829056 cites W2121604817 @default.
- W2895829056 cites W2127205775 @default.
- W2895829056 cites W2137632714 @default.
- W2895829056 cites W2137813387 @default.
- W2895829056 cites W2144086069 @default.
- W2895829056 cites W2144297861 @default.
- W2895829056 cites W2145973064 @default.
- W2895829056 cites W2146738944 @default.
- W2895829056 cites W2152119383 @default.
- W2895829056 cites W2152414953 @default.
- W2895829056 cites W2153982845 @default.
- W2895829056 cites W2157546299 @default.
- W2895829056 cites W2161527093 @default.
- W2895829056 cites W2166328287 @default.
- W2895829056 cites W2166686883 @default.
- W2895829056 cites W2166722062 @default.
- W2895829056 cites W2168746329 @default.
- W2895829056 cites W2170146596 @default.
- W2895829056 cites W2173612877 @default.
- W2895829056 cites W2193315289 @default.
- W2895829056 cites W2256882454 @default.
- W2895829056 cites W2309165118 @default.
- W2895829056 cites W2344057082 @default.
- W2895829056 cites W2488348433 @default.
- W2895829056 cites W2503766608 @default.
- W2895829056 cites W2532246947 @default.
- W2895829056 cites W2572596504 @default.
- W2895829056 cites W2587070774 @default.
- W2895829056 cites W2591036139 @default.
- W2895829056 cites W2603467153 @default.
- W2895829056 cites W2606168351 @default.
- W2895829056 cites W2621014178 @default.
- W2895829056 cites W2741178304 @default.
- W2895829056 cites W2744843428 @default.
- W2895829056 cites W2755780856 @default.