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• W2895829188 endingPage "e12964" @default.
• W2895829188 startingPage "e12964" @default.
• W2895829188 abstract "Malaria parasite transmission to humans is initiated by the inoculation of Plasmodium sporozoites into the skin by mosquitoes. Sporozoites develop within mosquito midgut oocysts, first invade the salivary glands of mosquitoes, and finally infect hepatocytes in mammals. The apical structure of sporozoites is conserved with the infective forms of other apicomplexan parasites that have secretory organelles, such as rhoptries and micronemes. Because some rhoptry proteins are crucial for Plasmodium merozoite infection of erythrocytes, we examined the roles of rhoptry proteins in sporozoites. Here, we demonstrate that rhoptry neck protein 2 (RON2) is also localized to rhoptries in sporozoites. To elucidate RON2 function in sporozoites, we applied a promoter swapping strategy to restrict ron2 transcription to the intraerythrocytic stage in the rodent malaria parasite, Plasmodium berghei. Ron2 knockdown sporozoites were severely impaired in their ability to invade salivary glands, via decreasing the attachment capacity to the substrate. This is the first rhoptry protein demonstrated to be involved in salivary gland invasion. In addition, ron2 knockdown sporozoites showed less infectivity to hepatocytes, possibly due to decreased attachment/gliding ability, indicating that parts of the parasite invasion machinery are conserved, but their contribution might differ among infective forms. Our sporozoite stage-specific knockdown system will help to facilitate understanding the comprehensive molecular mechanisms of parasite invasion of target cells." @default.
• W2895829188 created "2018-10-26" @default.
• W2895829188 creator A5011120142 @default.
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• W2895829188 creator A5085059342 @default.
• W2895829188 date "2018-10-30" @default.
• W2895829188 modified "2023-10-17" @default.
• W2895829188 title "Rhoptry neck protein 2 expressed in <scp> <i>Plasmodium</i> </scp> sporozoites plays a crucial role during invasion of mosquito salivary glands" @default.
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• W2895829188 doi "https://doi.org/10.1111/cmi.12964" @default.
• W2895829188 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6587811" @default.
• W2895829188 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30307699" @default.
• W2895829188 hasPublicationYear "2018" @default.
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