FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895829454> ?p ?o ?g. }

• W2895829454 endingPage "S52" @default.
• W2895829454 startingPage "S52" @default.
• W2895829454 abstract "To compare neuropsychological outcomes following PRT versus XRT for pediatric brain tumors. A total of 125 patients received treatment for tumors located in the supratentorial (17.6%), midline (28.8%) or posterior fossa (53.6%) compartments. All received age-appropriate neuropsychological assessment of intelligence quotient (IQ), processing speed (PS), visual motor integration (VMI), executive function, memory and parent-reported function at a single institution. Tests of IQ, PS, VMI and parent-reported functioning were standardized with mean of 100 and standard deviation of 15. Tests of digit and memory were scaled with mean of 10 and standard deviation of 3. Univariate and multivariate linear regression analyses were used to assess predictors of neuropsychological outcomes. Median age at diagnosis was 7.0 years; median time from treatment to last assessment was 4.0 years. Patients receiving PRT had higher socioeconomic status (SES), differing distributions of race and tumor locations, and shorter median time from treatment conclusion to last neuropsychological assessment compared to XRT (2.6 vs. 6.6 years, p<0.001). On univariate analyses, patients receiving PRT had higher mean verbal IQ (99.6 vs. 92.9, p=0.03), full-scale IQ (99.6 vs. 88.6, p=0.02), PS (86.9 vs. 80.0, p=0.03), VMI (87.1 vs. 80.8, p=0.04), general adaptive composite (91.4 vs. 80.7, p=0.04), conceptual function (94.6 vs. 84.1, p=0.002), social function (94.8 vs. 86.2, p=0.002), and practical function (91.1 vs. 78.9, p=0.002). There were no significant differences in digit span or long-term memory. Multivariate analyses including test for interaction with follow-up time identified higher full-scale IQ (β=10.6 points/year, p=0.048), PS (β=12.6, p=0.02), and parent-reported practical function (β=13.8, p=0.049) following PRT relative to XRT; lower PS (β=-15.9, p=0.04) and VMI (β=-14.0, p=0.006) following craniospinal irradiation (CSI); and higher verbal IQ (β=0.84, p=0.02) and full-scale IQ (β=1.03, p=0.01) for older patients. VMI was higher in those with higher SES (β=1.2 points/$10,000 household income, p=0.04), but lower following receipt of vincristine chemotherapy (β=-16.6, p=0.01). Parent-reported practical function was lower in those with posterior fossa tumors (β=-10.8, p=0.048). Subgroup analyses demonstrated that treatment with PRT, relative to XRT, was associated with higher full-scale IQ (β=17.2, p=0.02) following CSI or whole ventricular RT (n=76) and higher PS (β=22.6, p=0.01) following partial brain RT (n=49). In terms of full-scale IQ, processing speed, and parent-reported practical function, favorable neuropsychological outcomes are observed following PRT relative to XRT, with differences in full-scale IQ noted in patients receiving CSI or whole-ventricular RT and differences in processing speed noted in patients receiving partial brain RT." @default.
• W2895829454 created "2018-10-26" @default.
• W2895829454 creator A5002952095 @default.
• W2895829454 creator A5016499084 @default.
• W2895829454 creator A5022932491 @default.
• W2895829454 creator A5039958552 @default.
• W2895829454 creator A5046597561 @default.
• W2895829454 creator A5051462497 @default.
• W2895829454 creator A5052840712 @default.
• W2895829454 creator A5057941122 @default.
• W2895829454 creator A5071378074 @default.
• W2895829454 creator A5081230476 @default.
• W2895829454 date "2018-11-01" @default.
• W2895829454 modified "2023-09-28" @default.
• W2895829454 title "Neuropsychological Outcomes of Pediatric Brain Tumor Patients Treated with Proton (PRT) or X-ray (XRT) Radiation Therapy" @default.
• W2895829454 doi "https://doi.org/10.1016/j.ijrobp.2018.06.154" @default.
• W2895829454 hasPublicationYear "2018" @default.
• W2895829454 type Work @default.
• W2895829454 sameAs 2895829454 @default.
• W2895829454 citedByCount "0" @default.
• W2895829454 crossrefType "journal-article" @default.
• W2895829454 hasAuthorship W2895829454A5002952095 @default.
• W2895829454 hasAuthorship W2895829454A5016499084 @default.
• W2895829454 hasAuthorship W2895829454A5022932491 @default.
• W2895829454 hasAuthorship W2895829454A5039958552 @default.
• W2895829454 hasAuthorship W2895829454A5046597561 @default.
• W2895829454 hasAuthorship W2895829454A5051462497 @default.
• W2895829454 hasAuthorship W2895829454A5052840712 @default.
• W2895829454 hasAuthorship W2895829454A5057941122 @default.
• W2895829454 hasAuthorship W2895829454A5071378074 @default.
• W2895829454 hasAuthorship W2895829454A5081230476 @default.
• W2895829454 hasBestOaLocation W28958294541 @default.
• W2895829454 hasConcept C105795698 @default.
• W2895829454 hasConcept C118552586 @default.
• W2895829454 hasConcept C126322002 @default.
• W2895829454 hasConcept C14216870 @default.
• W2895829454 hasConcept C144301174 @default.
• W2895829454 hasConcept C161584116 @default.
• W2895829454 hasConcept C166047926 @default.
• W2895829454 hasConcept C169900460 @default.
• W2895829454 hasConcept C187212893 @default.
• W2895829454 hasConcept C199163554 @default.
• W2895829454 hasConcept C2989005 @default.
• W2895829454 hasConcept C33923547 @default.
• W2895829454 hasConcept C38180746 @default.
• W2895829454 hasConcept C536788834 @default.
• W2895829454 hasConcept C71924100 @default.
• W2895829454 hasConceptScore W2895829454C105795698 @default.
• W2895829454 hasConceptScore W2895829454C118552586 @default.
• W2895829454 hasConceptScore W2895829454C126322002 @default.
• W2895829454 hasConceptScore W2895829454C14216870 @default.
• W2895829454 hasConceptScore W2895829454C144301174 @default.
• W2895829454 hasConceptScore W2895829454C161584116 @default.
• W2895829454 hasConceptScore W2895829454C166047926 @default.
• W2895829454 hasConceptScore W2895829454C169900460 @default.
• W2895829454 hasConceptScore W2895829454C187212893 @default.
• W2895829454 hasConceptScore W2895829454C199163554 @default.
• W2895829454 hasConceptScore W2895829454C2989005 @default.
• W2895829454 hasConceptScore W2895829454C33923547 @default.
• W2895829454 hasConceptScore W2895829454C38180746 @default.
• W2895829454 hasConceptScore W2895829454C536788834 @default.
• W2895829454 hasConceptScore W2895829454C71924100 @default.
• W2895829454 hasIssue "3" @default.
• W2895829454 hasLocation W28958294541 @default.
• W2895829454 hasOpenAccess W2895829454 @default.
• W2895829454 hasPrimaryLocation W28958294541 @default.
• W2895829454 hasRelatedWork W1828158523 @default.
• W2895829454 hasRelatedWork W1987465999 @default.
• W2895829454 hasRelatedWork W1999135230 @default.
• W2895829454 hasRelatedWork W2082153206 @default.
• W2895829454 hasRelatedWork W2156374969 @default.
• W2895829454 hasRelatedWork W2160813944 @default.
• W2895829454 hasRelatedWork W2361144647 @default.
• W2895829454 hasRelatedWork W3146652434 @default.
• W2895829454 hasRelatedWork W3191791728 @default.
• W2895829454 hasRelatedWork W2183901182 @default.
• W2895829454 hasVolume "102" @default.
• W2895829454 isParatext "false" @default.
• W2895829454 isRetracted "false" @default.
• W2895829454 magId "2895829454" @default.
• W2895829454 workType "article" @default.