Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895829670> ?p ?o ?g. }
- W2895829670 abstract "Significance Coronaviruses (CoVs) are important pathogens for humans and domestic animals. The development of effective countermeasures against CoVs requires an understanding of the host pathways that regulate viral gene expression and the viral subversion mechanisms. However, little is known about how the stability of viral mRNAs is controlled. We show that the nonsense-mediated decay (NMD) pathway, which primarily targets aberrant cellular mRNAs for degradation, also induced the degradation of CoV mRNAs that are of cytoplasmic origin. Our study further suggests the importance of CoV-induced inhibition of the NMD pathway, mediated by a viral protein, for efficient CoV replication. The present study highlights an interplay between the NMD pathway and CoVs that modulates viral replication by controlling the stability of viral mRNAs." @default.
- W2895829670 created "2018-10-26" @default.
- W2895829670 creator A5024318533 @default.
- W2895829670 creator A5042004715 @default.
- W2895829670 creator A5050650401 @default.
- W2895829670 creator A5071530362 @default.
- W2895829670 creator A5071834465 @default.
- W2895829670 date "2018-10-08" @default.
- W2895829670 modified "2023-10-14" @default.
- W2895829670 title "Interplay between coronavirus, a cytoplasmic RNA virus, and nonsense-mediated mRNA decay pathway" @default.
- W2895829670 cites W1494090793 @default.
- W2895829670 cites W1544561280 @default.
- W2895829670 cites W1750901338 @default.
- W2895829670 cites W1822758711 @default.
- W2895829670 cites W1965546895 @default.
- W2895829670 cites W1965956757 @default.
- W2895829670 cites W1968468219 @default.
- W2895829670 cites W1968561529 @default.
- W2895829670 cites W1969841753 @default.
- W2895829670 cites W1979623919 @default.
- W2895829670 cites W1981887230 @default.
- W2895829670 cites W1985293164 @default.
- W2895829670 cites W1987050385 @default.
- W2895829670 cites W1996803605 @default.
- W2895829670 cites W1999144429 @default.
- W2895829670 cites W2003419284 @default.
- W2895829670 cites W2011055193 @default.
- W2895829670 cites W2020085699 @default.
- W2895829670 cites W2023373964 @default.
- W2895829670 cites W2037197127 @default.
- W2895829670 cites W2038360620 @default.
- W2895829670 cites W2040422211 @default.
- W2895829670 cites W2041245561 @default.
- W2895829670 cites W2043974181 @default.
- W2895829670 cites W2049975503 @default.
- W2895829670 cites W2050426823 @default.
- W2895829670 cites W2051379335 @default.
- W2895829670 cites W2056636829 @default.
- W2895829670 cites W2071680235 @default.
- W2895829670 cites W2072590456 @default.
- W2895829670 cites W2076941967 @default.
- W2895829670 cites W2077670520 @default.
- W2895829670 cites W2101472286 @default.
- W2895829670 cites W2103503670 @default.
- W2895829670 cites W2107533173 @default.
- W2895829670 cites W2121341109 @default.
- W2895829670 cites W2123998497 @default.
- W2895829670 cites W2127025250 @default.
- W2895829670 cites W2128364391 @default.
- W2895829670 cites W2131887043 @default.
- W2895829670 cites W2137888434 @default.
- W2895829670 cites W2140338292 @default.
- W2895829670 cites W2142812553 @default.
- W2895829670 cites W2144369724 @default.
- W2895829670 cites W2147131135 @default.
- W2895829670 cites W2153538433 @default.
- W2895829670 cites W2153891598 @default.
- W2895829670 cites W2156508926 @default.
- W2895829670 cites W2162195906 @default.
- W2895829670 cites W2163554972 @default.
- W2895829670 cites W2166964088 @default.
- W2895829670 cites W2234931430 @default.
- W2895829670 cites W2580855711 @default.
- W2895829670 cites W2580888383 @default.
- W2895829670 cites W2603636417 @default.
- W2895829670 cites W2747597014 @default.
- W2895829670 doi "https://doi.org/10.1073/pnas.1811675115" @default.
- W2895829670 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6205489" @default.
- W2895829670 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30297408" @default.
- W2895829670 hasPublicationYear "2018" @default.
- W2895829670 type Work @default.
- W2895829670 sameAs 2895829670 @default.
- W2895829670 citedByCount "83" @default.
- W2895829670 countsByYear W28958296702019 @default.
- W2895829670 countsByYear W28958296702020 @default.
- W2895829670 countsByYear W28958296702021 @default.
- W2895829670 countsByYear W28958296702022 @default.
- W2895829670 countsByYear W28958296702023 @default.
- W2895829670 crossrefType "journal-article" @default.
- W2895829670 hasAuthorship W2895829670A5024318533 @default.
- W2895829670 hasAuthorship W2895829670A5042004715 @default.
- W2895829670 hasAuthorship W2895829670A5050650401 @default.
- W2895829670 hasAuthorship W2895829670A5071530362 @default.
- W2895829670 hasAuthorship W2895829670A5071834465 @default.
- W2895829670 hasBestOaLocation W28958296701 @default.
- W2895829670 hasConcept C104317684 @default.
- W2895829670 hasConcept C105580179 @default.
- W2895829670 hasConcept C140704245 @default.
- W2895829670 hasConcept C142724271 @default.
- W2895829670 hasConcept C150194340 @default.
- W2895829670 hasConcept C159047783 @default.
- W2895829670 hasConcept C2522874641 @default.
- W2895829670 hasConcept C2777648638 @default.
- W2895829670 hasConcept C2779134260 @default.
- W2895829670 hasConcept C3008058167 @default.
- W2895829670 hasConcept C524204448 @default.
- W2895829670 hasConcept C54355233 @default.
- W2895829670 hasConcept C54458228 @default.
- W2895829670 hasConcept C58475186 @default.
- W2895829670 hasConcept C67705224 @default.