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- W2895831187 abstract "Exploratory analyses of flortaucipir F 18 PET in the EXPEDITION3 phase 3 trial of patients with mild Alzheimer's disease (AD) revealed a potential utility of flortaucipir to stratify risk of cognitive decline (Mintun MA et al, AAIC-2017). Moreover, modeled regional trajectories demonstrated a stereotypical lobar sequence of tau accumulation (Shcherbinin S et al, AAIC-2017). The aim of this study was to develop a simple, quantitative tau PET-based patient classification algorithm based on sequential lobar accumulation of flortaucipir signal. The EXPEDITION3 trial enrolled amyloid-positive patients with mild AD (MMSE 20-26). Flortaucipir images were acquired for a subset of participants at baseline, week 40 and week 80. We quantified tau burden in baseline scans from the placebo arm (N=97), using average SUVR values in atlas-based lateral temporal, parietal and frontal lobes with respect to a white matter-based reference region (PERSI). Elevated tau burden in the temporal (T+), parietal (P+) and frontal (F+) lobes bilaterally was determined using a single positivity threshold. All possible lobar profiles were grouped into four stages 0-III (T-P-F-, T+P-F-, T+/-P+F- and T+/-P+/-F+), reflecting the stereotypical patterns of tau spread inferred from neuropathological studies. A mixed effects repeated measures method was used to characterize changes in global weighted SUVR (MUBADA), cognition and structural MRI. Lobar stages were strongly concordant with a global tau burden measured by MUBADA SUVR. On average, individuals belonging to more advanced lobar stages at baseline demonstrated numerically more rapid cognitive (MMSE, ADAS-Cog14 and iADRS) and neurodegenerative (whole brain and whole temporal lobe volumes) decline over 80 weeks follow-up. In these analyses, approximately 25-30% of the cases were classified to each of stages I-III, with a slightly lower proportion assigned to stage 0. If scans were staged using a more rigorous sequential classification (T-P-F-, T+P-F-, T+P+F- and T+P+F+), <5% scans remained unclassified." @default.
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- W2895831187 date "2018-07-01" @default.
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- W2895831187 title "IC‐P‐216: LOBAR CLASSIFICATION OF TAU PET IMAGES IN THE EXPEDITION‐3 TRIAL" @default.
- W2895831187 doi "https://doi.org/10.1016/j.jalz.2018.06.2283" @default.
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