Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895833591> ?p ?o ?g. }
- W2895833591 endingPage "114" @default.
- W2895833591 startingPage "99" @default.
- W2895833591 abstract "Pyroptosis and necroptosis represent two pathways of genetically encoded necrotic cell death. Although these cell death programmes can protect the host against microbial pathogens, their dysregulation has been implicated in a variety of autoimmune and auto-inflammatory conditions. The disease-promoting potential of necroptosis and pyroptosis is likely a consequence of their ability to induce a lytic cell death. This cell suicide mechanism, distinct from apoptosis, allows the release of immunogenic cellular content, including damage-associated molecular patterns (DAMPs), and inflammatory cytokines such as interleukin-1β (IL-1β), to trigger inflammation. In this Review, we discuss recent discoveries that have advanced our understanding on the primary functions of pyroptosis and necroptosis, including evidence for the specific cytokines and DAMPs responsible for driving inflammation. We compare the similar and unique aspects of pyroptotic- and necroptotic-induced membrane damage, and explore how these may functionally impact distinct intracellular organelles and signalling pathways. We also examine studies highlighting the crosstalk that can occur between necroptosis and pyroptosis signalling, and evidence supporting the physiological significance of this convergence. Ultimately, a better understanding of the similarities, unique aspects and crosstalk of pyroptosis and necroptosis will inform as to how these cell death pathways might be manipulated for therapeutic benefit." @default.
- W2895833591 created "2018-10-26" @default.
- W2895833591 creator A5031697471 @default.
- W2895833591 creator A5056289876 @default.
- W2895833591 date "2018-10-19" @default.
- W2895833591 modified "2023-10-18" @default.
- W2895833591 title "Pyroptosis versus necroptosis: similarities, differences, and crosstalk" @default.
- W2895833591 cites W1515879175 @default.
- W2895833591 cites W1523845694 @default.
- W2895833591 cites W1560867514 @default.
- W2895833591 cites W1562692846 @default.
- W2895833591 cites W1630899685 @default.
- W2895833591 cites W1847056372 @default.
- W2895833591 cites W1850224498 @default.
- W2895833591 cites W1861790843 @default.
- W2895833591 cites W1864325817 @default.
- W2895833591 cites W1871390418 @default.
- W2895833591 cites W1882905539 @default.
- W2895833591 cites W1904683780 @default.
- W2895833591 cites W1966977448 @default.
- W2895833591 cites W1968946043 @default.
- W2895833591 cites W1969323641 @default.
- W2895833591 cites W1971998620 @default.
- W2895833591 cites W1972483153 @default.
- W2895833591 cites W1975593978 @default.
- W2895833591 cites W1979995829 @default.
- W2895833591 cites W1981237612 @default.
- W2895833591 cites W1983840749 @default.
- W2895833591 cites W1984699561 @default.
- W2895833591 cites W1985042500 @default.
- W2895833591 cites W1992789370 @default.
- W2895833591 cites W1994190235 @default.
- W2895833591 cites W2001153857 @default.
- W2895833591 cites W2004266769 @default.
- W2895833591 cites W2007303185 @default.
- W2895833591 cites W2007898062 @default.
- W2895833591 cites W2008961838 @default.
- W2895833591 cites W2009800174 @default.
- W2895833591 cites W2015879727 @default.
- W2895833591 cites W2018563185 @default.
- W2895833591 cites W2023368253 @default.
- W2895833591 cites W2028017703 @default.
- W2895833591 cites W2028107828 @default.
- W2895833591 cites W2028432878 @default.
- W2895833591 cites W2028832882 @default.
- W2895833591 cites W2029320450 @default.
- W2895833591 cites W2029673642 @default.
- W2895833591 cites W2032370476 @default.
- W2895833591 cites W2033968700 @default.
- W2895833591 cites W2034591877 @default.
- W2895833591 cites W2038182824 @default.
- W2895833591 cites W2041624512 @default.
- W2895833591 cites W2041850473 @default.
- W2895833591 cites W2042577315 @default.
- W2895833591 cites W2048588387 @default.
- W2895833591 cites W2052853635 @default.
- W2895833591 cites W2060204808 @default.
- W2895833591 cites W2068619092 @default.
- W2895833591 cites W2069526125 @default.
- W2895833591 cites W2070243355 @default.
- W2895833591 cites W2074213282 @default.
- W2895833591 cites W2074747472 @default.
- W2895833591 cites W2076063079 @default.
- W2895833591 cites W2077317536 @default.
- W2895833591 cites W2078141613 @default.
- W2895833591 cites W2078252006 @default.
- W2895833591 cites W2078489088 @default.
- W2895833591 cites W2079096997 @default.
- W2895833591 cites W2079882002 @default.
- W2895833591 cites W2080030672 @default.
- W2895833591 cites W2080827095 @default.
- W2895833591 cites W2081745303 @default.
- W2895833591 cites W2084708403 @default.
- W2895833591 cites W2085006338 @default.
- W2895833591 cites W2087232320 @default.
- W2895833591 cites W2087968540 @default.
- W2895833591 cites W2090263751 @default.
- W2895833591 cites W2090859543 @default.
- W2895833591 cites W2091363184 @default.
- W2895833591 cites W2093498058 @default.
- W2895833591 cites W2097714951 @default.
- W2895833591 cites W2103572248 @default.
- W2895833591 cites W2103806424 @default.
- W2895833591 cites W2110796758 @default.
- W2895833591 cites W2111822935 @default.
- W2895833591 cites W2113010696 @default.
- W2895833591 cites W2117584263 @default.
- W2895833591 cites W2118621467 @default.
- W2895833591 cites W2120626244 @default.
- W2895833591 cites W2123531771 @default.
- W2895833591 cites W2124396497 @default.
- W2895833591 cites W2126693439 @default.
- W2895833591 cites W2130002934 @default.
- W2895833591 cites W2130153302 @default.
- W2895833591 cites W2132161879 @default.
- W2895833591 cites W2134219545 @default.
- W2895833591 cites W2140655321 @default.
- W2895833591 cites W2143119237 @default.