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- W2895834930 endingPage "516" @default.
- W2895834930 startingPage "461" @default.
- W2895834930 abstract "Pteridines are aromatic compounds formed by fused pyrazine and pyrimidine rings. Many living organisms synthesize pteridines, where they act as pigments, enzymatic cofactors, or immune system activation molecules. This variety of biological functions has motivated the synthesis of a huge number of pteridine derivatives with the aim of studying their therapeutic potential. This review gathers the state-of-the-art of pteridine derivatives, describing their biological activities and molecular targets. The antitumor activity of pteridine-based compounds is one of the most studied and advanced therapeutic potentials, for which several molecular targets have been identified. Nevertheless, pteridines are also considered as very promising therapeutics for the treatment of chronic inflammation-related diseases. On the other hand, many pteridine derivatives have been tested for antimicrobial activities but, although some of them resulted to be active in preliminary assays, a deeper research is needed in this area. Moreover, pteridines may be of use in the treatment of many other diseases, such as diabetes, osteoporosis, ischemia, or neurodegeneration, among others. Thus, the diversity of the biological activities shown by these compounds highlights the promising therapeutic use of pteridine derivatives. Indeed, methotrexate, pralatrexate, and triamterene are Food and Drug Administration approved pteridines, while many others are currently under study in clinical trials." @default.
- W2895834930 created "2018-10-26" @default.
- W2895834930 creator A5004411908 @default.
- W2895834930 creator A5022474224 @default.
- W2895834930 creator A5034634907 @default.
- W2895834930 creator A5075246170 @default.
- W2895834930 creator A5088311911 @default.
- W2895834930 creator A5090128810 @default.
- W2895834930 date "2018-10-19" @default.
- W2895834930 modified "2023-10-18" @default.
- W2895834930 title "Therapeutic potential of pteridine derivatives: A comprehensive review" @default.
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