FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895836323> ?p ?o ?g. }

• W2895836323 endingPage "e739" @default.
• W2895836323 startingPage "e739" @default.
• W2895836323 abstract "Patient reported outcomes such as quality of life (QOL) are increasingly utilized to assess quality and value of medical care. In 2015 we instituted a prospective patient outcomes registry and biobank to evaluate patient reported toxicities, clinical outcomes, and QOL in a large, multi-site practice to establish quality metrics as well as correlate genetic factors with patient outcomes. In this first report, we aimed to evaluate early QOL changes in patients receiving fractionated external beam (proton/photon) radiotherapy (RT). Institutional prospective outcomes registry was utilized to identify all patients treated with curative intent RT receiving >14 fractions of RT who had completed both a baseline and end of RT PROMIS10 questionnaire between July 1, 2015 and December 31, 2017. PROMIS10 uses a 5-point Likert scale and allows measurements of symptoms, functioning, and healthcare-related QOL. Scores were dichotomized into normal/near-normal (4,5) vs all other (1-3) for individual item analysis. Decline in QOL was defined as a ≥2-point change in score as compared to baseline for each question analyzed by individual patient responses. Baseline scores, as well as change in scores from baseline to end of RT, were compared between patient groups using a Wilcoxon rank sum test. Chi-square analysis was performed for associations of QOL and patient and treatment factors. Of 3297 eligible patients, 2203 (67%) completed baseline and end of RT questionnaires and included in this analysis. Mean age was 61.8 years (range 18.5-94.4); 45% were female and 27% received proton RT. Distribution of disease sites treated are as follows: breast (25%), prostate (21%), gastrointestinal (15%), head/neck (14%), central nervous system (9%), sarcoma (5%), lung (4%), lymphoma (2%), and gynecologic (2%). For each of the 10 questions/domains, 10% or fewer of patients experienced declines in QOL at the end of RT. Greater than 10% declines in physical domains of QOL were seen in head/neck, gastrointestinal, and lung patients. Younger age and higher-stage was associated with lower global physical and mental health scores (p<0.001 for each) at the end of therapy. Patients receiving proton RT reported less impairment in carrying out daily physical activities at baseline (19% vs 25%, p <0.01) but there were no significant differences in baseline global QOL scores. Proton RT was associated with less decline in global physical score but the difference is small (median 0 vs -2.5, p<0.01) and likely due to less fatigue (50% vs 55%, p=0.02) and less difficulty carrying out daily physical activities (24% vs 34%, p<0.01) reported at the end of treatment. In a large multi-site practice, PROMIS10 survey appears useful in documenting changes in QOL in the acute setting. Proton RT may be associated with reduced declines in physical QOL. Further efforts to improve compliance with end-of-treatment surveys are ongoing." @default.
• W2895836323 created "2018-10-26" @default.
• W2895836323 creator A5002852278 @default.
• W2895836323 creator A5005280547 @default.
• W2895836323 creator A5006151030 @default.
• W2895836323 creator A5006321078 @default.
• W2895836323 creator A5024662261 @default.
• W2895836323 creator A5033323953 @default.
• W2895836323 creator A5044847415 @default.
• W2895836323 creator A5044939667 @default.
• W2895836323 creator A5046346119 @default.
• W2895836323 creator A5049582249 @default.
• W2895836323 creator A5053276726 @default.
• W2895836323 creator A5055991332 @default.
• W2895836323 creator A5057236689 @default.
• W2895836323 creator A5062848479 @default.
• W2895836323 creator A5067520533 @default.
• W2895836323 creator A5071466700 @default.
• W2895836323 creator A5071942279 @default.
• W2895836323 creator A5079400879 @default.
• W2895836323 creator A5082993331 @default.
• W2895836323 creator A5083170859 @default.
• W2895836323 creator A5091023123 @default.
• W2895836323 date "2018-11-01" @default.
• W2895836323 modified "2023-10-14" @default.
• W2895836323 title "Patient-reported Quality of Life during Photon and Proton Radiation Therapy: Results of a Prospective Registry of Patient Reported Outcomes in a Large-Volume, Multi-Site Practice" @default.
• W2895836323 doi "https://doi.org/10.1016/j.ijrobp.2018.07.1977" @default.
• W2895836323 hasPublicationYear "2018" @default.
• W2895836323 type Work @default.
• W2895836323 sameAs 2895836323 @default.
• W2895836323 citedByCount "0" @default.
• W2895836323 crossrefType "journal-article" @default.
• W2895836323 hasAuthorship W2895836323A5002852278 @default.
• W2895836323 hasAuthorship W2895836323A5005280547 @default.
• W2895836323 hasAuthorship W2895836323A5006151030 @default.
• W2895836323 hasAuthorship W2895836323A5006321078 @default.
• W2895836323 hasAuthorship W2895836323A5024662261 @default.
• W2895836323 hasAuthorship W2895836323A5033323953 @default.
• W2895836323 hasAuthorship W2895836323A5044847415 @default.
• W2895836323 hasAuthorship W2895836323A5044939667 @default.
• W2895836323 hasAuthorship W2895836323A5046346119 @default.
• W2895836323 hasAuthorship W2895836323A5049582249 @default.
• W2895836323 hasAuthorship W2895836323A5053276726 @default.
• W2895836323 hasAuthorship W2895836323A5055991332 @default.
• W2895836323 hasAuthorship W2895836323A5057236689 @default.
• W2895836323 hasAuthorship W2895836323A5062848479 @default.
• W2895836323 hasAuthorship W2895836323A5067520533 @default.
• W2895836323 hasAuthorship W2895836323A5071466700 @default.
• W2895836323 hasAuthorship W2895836323A5071942279 @default.
• W2895836323 hasAuthorship W2895836323A5079400879 @default.
• W2895836323 hasAuthorship W2895836323A5082993331 @default.
• W2895836323 hasAuthorship W2895836323A5083170859 @default.
• W2895836323 hasAuthorship W2895836323A5091023123 @default.
• W2895836323 hasConcept C111278954 @default.
• W2895836323 hasConcept C126322002 @default.
• W2895836323 hasConcept C12868164 @default.
• W2895836323 hasConcept C159110408 @default.
• W2895836323 hasConcept C168563851 @default.
• W2895836323 hasConcept C1862650 @default.
• W2895836323 hasConcept C188816634 @default.
• W2895836323 hasConcept C206041023 @default.
• W2895836323 hasConcept C2779517570 @default.
• W2895836323 hasConcept C2779951463 @default.
• W2895836323 hasConcept C71924100 @default.
• W2895836323 hasConceptScore W2895836323C111278954 @default.
• W2895836323 hasConceptScore W2895836323C126322002 @default.
• W2895836323 hasConceptScore W2895836323C12868164 @default.
• W2895836323 hasConceptScore W2895836323C159110408 @default.
• W2895836323 hasConceptScore W2895836323C168563851 @default.
• W2895836323 hasConceptScore W2895836323C1862650 @default.
• W2895836323 hasConceptScore W2895836323C188816634 @default.
• W2895836323 hasConceptScore W2895836323C206041023 @default.
• W2895836323 hasConceptScore W2895836323C2779517570 @default.
• W2895836323 hasConceptScore W2895836323C2779951463 @default.
• W2895836323 hasConceptScore W2895836323C71924100 @default.
• W2895836323 hasIssue "3" @default.
• W2895836323 hasLocation W28958363231 @default.
• W2895836323 hasOpenAccess W2895836323 @default.
• W2895836323 hasPrimaryLocation W28958363231 @default.
• W2895836323 hasRelatedWork W1993503267 @default.
• W2895836323 hasRelatedWork W1995872510 @default.
• W2895836323 hasRelatedWork W2013136801 @default.
• W2895836323 hasRelatedWork W2230990660 @default.
• W2895836323 hasRelatedWork W2973108776 @default.
• W2895836323 hasRelatedWork W3216046431 @default.
• W2895836323 hasRelatedWork W4200606767 @default.
• W2895836323 hasRelatedWork W4225966454 @default.
• W2895836323 hasRelatedWork W4244474738 @default.
• W2895836323 hasRelatedWork W4323350313 @default.
• W2895836323 hasVolume "102" @default.
• W2895836323 isParatext "false" @default.
• W2895836323 isRetracted "false" @default.
• W2895836323 magId "2895836323" @default.
• W2895836323 workType "article" @default.