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- W2895836911 abstract "Abstract Genome organization involves cis and trans chromosomal interactions, both implicated in gene regulation, development, and disease. Here, we focused on trans interactions in Drosophila , where homologous chromosomes are paired in somatic cells from embryogenesis through adulthood. We first addressed the long-standing question of whether pairing extends genome-wide and, to this end, developed a haplotype-resolved Hi-C approach that uses a new strategy to minimize homolog misassignment and thus robustly distinguish trans -homolog from cis contacts. This approach revealed striking genome-wide pairing in Drosophila embryos. Moreover, we discovered pairing to be surprisingly structured, with trans -homolog domains and interaction peaks, many coinciding with the positions of analogous cis features. We also found a significant correlation between pairing and the chromatin accessibility mediated by the pioneer factor Zelda. Our findings reveal a complex, highly structured organization underlying homolog pairing, first discovered more than a century ago. One Sentence Summary A robust approach for haplotype-resolved Hi-C reveals highly-structured homolog pairing in early stage Drosophila embryos." @default.
- W2895836911 created "2018-10-26" @default.
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- W2895836911 date "2018-10-17" @default.
- W2895836911 modified "2023-10-01" @default.
- W2895836911 title "The genome-wide, multi-layered architecture of chromosome pairing in early<i>Drosophila</i>embryos" @default.
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- W2895836911 doi "https://doi.org/10.1101/443028" @default.
- W2895836911 hasPublicationYear "2018" @default.
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