FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895837181> ?p ?o ?g. }

• W2895837181 endingPage "390" @default.
• W2895837181 startingPage "382" @default.
• W2895837181 abstract "Platinum and etoposide with thoracic radiation followed by prophylactic cranial irradiation constitute the standard treatment for limited-stage small cell lung cancer (LS-SCLC). Many patients with LS-SCLC are elderly with comorbidities.Individual patient data were collected from 11 phase 2 or 3 trials for LS-SCLC conducted by the National Clinical Trials Network and activated from 1990 to 2010. The primary endpoint was overall survival (OS); the secondary endpoints were progression-free survival (PFS), the rate of severe adverse events, and off-treatment reasons. The outcomes were compared for patients 70 years old or older (elderly patients) and patients younger than 70 years (younger patients).Individual patient data from 1049 younger patients (81%) and 254 elderly patients (19%) were analyzed. In the multivariate model, elderly patients, in comparison with younger patients, had worse OS (hazard ratio [HR], 1.38; 95% confidence interval [CI], 1.18-1.63; median OS for elderly patients, 17.8 months; OS for younger patients, 23.5 months) and worse PFS (HR, 1.19; 95% CI, 1.03-1.39; median PFS for elderly patients, 10.6 months; median PFS for younger patients, 12.3 months). Elderly patients, in comparison with younger patients, experienced more grade 5 adverse events (8% vs 3%; P < .01) and more grade 3 or higher dyspnea (11% vs 7%; P = .03) but less grade 3 or higher esophagitis/dysphagia (14% vs 19%; P = .04) and less grade 3 or higher vomiting (11% vs 17%; P = .01). Elderly patients completed treatment less often, discontinued treatment because of adverse events and patient refusal more frequently, and died during treatment more frequently.Elderly patients with LS-SCLC have worse PFS and OS and more difficulty in tolerating therapy. Future trials should incorporate assessments of elderly patients, novel monitoring of adverse events, and more tolerable radiation and systemic therapies." @default.
• W2895837181 created "2018-10-26" @default.
• W2895837181 creator A5006430883 @default.
• W2895837181 creator A5014554706 @default.
• W2895837181 creator A5020320446 @default.
• W2895837181 creator A5023696543 @default.
• W2895837181 creator A5024497224 @default.
• W2895837181 creator A5025883417 @default.
• W2895837181 creator A5028702225 @default.
• W2895837181 creator A5032903376 @default.
• W2895837181 creator A5062848479 @default.
• W2895837181 creator A5062894702 @default.
• W2895837181 creator A5063441489 @default.
• W2895837181 creator A5063904421 @default.
• W2895837181 creator A5084337375 @default.
• W2895837181 creator A5091279526 @default.
• W2895837181 date "2018-10-21" @default.
• W2895837181 modified "2023-10-11" @default.
• W2895837181 title "A pooled analysis of individual patient data from National Clinical Trials Network clinical trials of concurrent chemoradiotherapy for limited‐stage small cell lung cancer in elderly patients versus younger patients" @default.
• W2895837181 cites W1513889020 @default.
• W2895837181 cites W1554896841 @default.
• W2895837181 cites W1973318362 @default.
• W2895837181 cites W1991585418 @default.
• W2895837181 cites W1994351520 @default.
• W2895837181 cites W2010674816 @default.
• W2895837181 cites W2011868684 @default.
• W2895837181 cites W2017967967 @default.
• W2895837181 cites W2020882823 @default.
• W2895837181 cites W2021987821 @default.
• W2895837181 cites W2028930334 @default.
• W2895837181 cites W2041282815 @default.
• W2895837181 cites W2041493922 @default.
• W2895837181 cites W2047994314 @default.
• W2895837181 cites W2056320672 @default.
• W2895837181 cites W2057375284 @default.
• W2895837181 cites W2062668422 @default.
• W2895837181 cites W2067686632 @default.
• W2895837181 cites W2076995418 @default.
• W2895837181 cites W2078709072 @default.
• W2895837181 cites W2106672370 @default.
• W2895837181 cites W2127248382 @default.
• W2895837181 cites W2131664752 @default.
• W2895837181 cites W2141032252 @default.
• W2895837181 cites W2143124651 @default.
• W2895837181 cites W2145601586 @default.
• W2895837181 cites W2146064654 @default.
• W2895837181 cites W2149386818 @default.
• W2895837181 cites W2157903728 @default.
• W2895837181 cites W2169848988 @default.
• W2895837181 cites W2170768661 @default.
• W2895837181 cites W2398917392 @default.
• W2895837181 cites W2521786544 @default.
• W2895837181 cites W2528393079 @default.
• W2895837181 cites W2620925856 @default.
• W2895837181 cites W2699278758 @default.
• W2895837181 cites W2893960509 @default.
• W2895837181 cites W3031228654 @default.
• W2895837181 cites W3140025388 @default.
• W2895837181 cites W4231261413 @default.
• W2895837181 doi "https://doi.org/10.1002/cncr.31813" @default.
• W2895837181 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6340765" @default.
• W2895837181 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30343497" @default.
• W2895837181 hasPublicationYear "2018" @default.
• W2895837181 type Work @default.
• W2895837181 sameAs 2895837181 @default.
• W2895837181 citedByCount "12" @default.
• W2895837181 countsByYear W28958371812019 @default.
• W2895837181 countsByYear W28958371812020 @default.
• W2895837181 countsByYear W28958371812021 @default.
• W2895837181 countsByYear W28958371812022 @default.
• W2895837181 countsByYear W28958371812023 @default.
• W2895837181 crossrefType "journal-article" @default.
• W2895837181 hasAuthorship W2895837181A5006430883 @default.
• W2895837181 hasAuthorship W2895837181A5014554706 @default.
• W2895837181 hasAuthorship W2895837181A5020320446 @default.
• W2895837181 hasAuthorship W2895837181A5023696543 @default.
• W2895837181 hasAuthorship W2895837181A5024497224 @default.
• W2895837181 hasAuthorship W2895837181A5025883417 @default.
• W2895837181 hasAuthorship W2895837181A5028702225 @default.
• W2895837181 hasAuthorship W2895837181A5032903376 @default.
• W2895837181 hasAuthorship W2895837181A5062848479 @default.
• W2895837181 hasAuthorship W2895837181A5062894702 @default.
• W2895837181 hasAuthorship W2895837181A5063441489 @default.
• W2895837181 hasAuthorship W2895837181A5063904421 @default.
• W2895837181 hasAuthorship W2895837181A5084337375 @default.
• W2895837181 hasAuthorship W2895837181A5091279526 @default.
• W2895837181 hasBestOaLocation W28958371811 @default.
• W2895837181 hasConcept C126322002 @default.
• W2895837181 hasConcept C141071460 @default.
• W2895837181 hasConcept C197934379 @default.
• W2895837181 hasConcept C203092338 @default.
• W2895837181 hasConcept C207103383 @default.
• W2895837181 hasConcept C2776256026 @default.
• W2895837181 hasConcept C2778424827 @default.
• W2895837181 hasConcept C2779134260 @default.
• W2895837181 hasConcept C2779920096 @default.
• W2895837181 hasConcept C2780596822 @default.
• W2895837181 hasConcept C43270747 @default.

• next