Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895838316> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2895838316 abstract "Fibrinogen is a glycoprotein with a crucial role in blood coagulation. Upon enzymatic cleavage by thrombin, fibrinogen is converted from its soluble form to insoluble fibrin which is key structural protein of a clot. It also participates in platelet aggregation by binding to GPIIb/IIIa. Genetic alterations can lead to either complete or partial, quantitative or qualitative defects of fibrinogen. Inherited afibrinogenemia is a rare bleeding disorder with autosomal recessive inheritance due to a complete absence of fibrinogen. The primary aim of this study was to determine whether 70 mg/kg of human fibrinogen concentrate (HFC) is an adequate dose in subjects with inherited afibrinogenemia to reach normal levels of plasmatic fibrinogen (1.5-2 g/L). Secondary aims included assessing changes in thromboelastography (TEG) and thrombin generation assay (TGA) before and after a dose of HFC. Four patients were included, and each underwent pre-and post (one time-point) HFC dose laboratory testing. Two patients needed dose adjustments to reach a normal post-dose fibrinogen level. In addition, we noted that the TEG parameter maximum amplitude (MA) improved in accordance with correction of the fibrinogen levels. TGA results were normal in all subjects. Our results suggest that individualized dosing based on fibrinogen levels may be necessary." @default.
- W2895838316 created "2018-10-26" @default.
- W2895838316 creator A5018987356 @default.
- W2895838316 creator A5050451275 @default.
- W2895838316 creator A5070156690 @default.
- W2895838316 date "2018-10-21" @default.
- W2895838316 modified "2023-09-25" @default.
- W2895838316 title "Thromboelastography and thrombin generation assay in inherited afibrinogenemia" @default.
- W2895838316 cites W1520920065 @default.
- W2895838316 cites W194268429 @default.
- W2895838316 cites W1970217192 @default.
- W2895838316 cites W2006928595 @default.
- W2895838316 cites W2011758847 @default.
- W2895838316 cites W2030548293 @default.
- W2895838316 cites W2036828326 @default.
- W2895838316 cites W2058855753 @default.
- W2895838316 cites W2064242386 @default.
- W2895838316 cites W2076636814 @default.
- W2895838316 cites W2081273535 @default.
- W2895838316 cites W2105108862 @default.
- W2895838316 cites W2126609456 @default.
- W2895838316 cites W2139431062 @default.
- W2895838316 cites W2761788611 @default.
- W2895838316 doi "https://doi.org/10.1111/hae.13620" @default.
- W2895838316 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30345592" @default.
- W2895838316 hasPublicationYear "2018" @default.
- W2895838316 type Work @default.
- W2895838316 sameAs 2895838316 @default.
- W2895838316 citedByCount "10" @default.
- W2895838316 countsByYear W28958383162019 @default.
- W2895838316 countsByYear W28958383162020 @default.
- W2895838316 countsByYear W28958383162021 @default.
- W2895838316 countsByYear W28958383162022 @default.
- W2895838316 countsByYear W28958383162023 @default.
- W2895838316 crossrefType "journal-article" @default.
- W2895838316 hasAuthorship W2895838316A5018987356 @default.
- W2895838316 hasAuthorship W2895838316A5050451275 @default.
- W2895838316 hasAuthorship W2895838316A5070156690 @default.
- W2895838316 hasConcept C126322002 @default.
- W2895838316 hasConcept C203014093 @default.
- W2895838316 hasConcept C26809991 @default.
- W2895838316 hasConcept C2777292125 @default.
- W2895838316 hasConcept C2777664302 @default.
- W2895838316 hasConcept C2778261982 @default.
- W2895838316 hasConcept C2778382381 @default.
- W2895838316 hasConcept C2779036427 @default.
- W2895838316 hasConcept C2780077467 @default.
- W2895838316 hasConcept C2910029113 @default.
- W2895838316 hasConcept C2910129229 @default.
- W2895838316 hasConcept C3018972837 @default.
- W2895838316 hasConcept C54173615 @default.
- W2895838316 hasConcept C71924100 @default.
- W2895838316 hasConcept C89560881 @default.
- W2895838316 hasConcept C98274493 @default.
- W2895838316 hasConceptScore W2895838316C126322002 @default.
- W2895838316 hasConceptScore W2895838316C203014093 @default.
- W2895838316 hasConceptScore W2895838316C26809991 @default.
- W2895838316 hasConceptScore W2895838316C2777292125 @default.
- W2895838316 hasConceptScore W2895838316C2777664302 @default.
- W2895838316 hasConceptScore W2895838316C2778261982 @default.
- W2895838316 hasConceptScore W2895838316C2778382381 @default.
- W2895838316 hasConceptScore W2895838316C2779036427 @default.
- W2895838316 hasConceptScore W2895838316C2780077467 @default.
- W2895838316 hasConceptScore W2895838316C2910029113 @default.
- W2895838316 hasConceptScore W2895838316C2910129229 @default.
- W2895838316 hasConceptScore W2895838316C3018972837 @default.
- W2895838316 hasConceptScore W2895838316C54173615 @default.
- W2895838316 hasConceptScore W2895838316C71924100 @default.
- W2895838316 hasConceptScore W2895838316C89560881 @default.
- W2895838316 hasConceptScore W2895838316C98274493 @default.
- W2895838316 hasIssue "6" @default.
- W2895838316 hasLocation W28958383161 @default.
- W2895838316 hasLocation W28958383162 @default.
- W2895838316 hasOpenAccess W2895838316 @default.
- W2895838316 hasPrimaryLocation W28958383161 @default.
- W2895838316 hasRelatedWork W189162726 @default.
- W2895838316 hasRelatedWork W2023345487 @default.
- W2895838316 hasRelatedWork W2055595677 @default.
- W2895838316 hasRelatedWork W2058855753 @default.
- W2895838316 hasRelatedWork W2065350453 @default.
- W2895838316 hasRelatedWork W2601077424 @default.
- W2895838316 hasRelatedWork W2889995622 @default.
- W2895838316 hasRelatedWork W2895838316 @default.
- W2895838316 hasRelatedWork W3003410353 @default.
- W2895838316 hasRelatedWork W4206058282 @default.
- W2895838316 hasVolume "24" @default.
- W2895838316 isParatext "false" @default.
- W2895838316 isRetracted "false" @default.
- W2895838316 magId "2895838316" @default.
- W2895838316 workType "article" @default.