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- W2895838775 abstract "Background: Psoriasis is a common chronic skin disorder with prevalence of 2.7% in Iraqi community. Psoriasis is a skin disease that it's prevalence affected by many factors which include genetic, environmental, infectious, immunological, biochemical, endocrinological and psychological. Psoriasis is a chronic inflammatory disease with unknown exact pathogenesis, which may be started as skin condition that subsequently associated with systemic complications. The recurrent proliferative inflammatory processes in subject with psoriasis may lead to abnormal lipid metabolism and associated with cardiovascular diseases
 Aim: This study aims at determining some biochemical parameters of psoriasis .
 Results: Paraoxonase enzyme which act as antioxidant was significantly decreased in patients with psoriasis as compared to healthy controls. Thus the present study data suggest that PON 1 play an important role in pathogenesis of psoriasis. There was a high significant increase of lipoprotein (a) compared with controls. Lipoprotein (a) may be a risk factor contributing to an increased cardiovascular risk in patients with psoriasis. The frequency of positivity of CRP as inflammatory markers of psoriasis was significantly more in patients with psoriasis as compared to controls. Although, reported studies suggest that increased levels of CRP in psoriasis may be a good assessment of disease severity and prognosis, however, there are some discrepancies in this area. But PASI and CRP are with good predictor of psoriasis severity. A non significant difference in the serum mean of fasting blood level between patients with psoriasis relative to controls. All lipid profiles ( cholesterol, triglyceride, HDL, LDL, VLDL, and NHDL) were significantly higher in psoriasis patients compared to controls. While HDL was significantly lower in patients with psoriasis than in control. In addition, the differences between male psoriasis and male controls were significant. The same pattern was demonstrated for comparison of fem ale psoriasis to female controls." @default.
- W2895838775 created "2018-10-26" @default.
- W2895838775 creator A5012867069 @default.
- W2895838775 date "2018-08-01" @default.
- W2895838775 modified "2023-09-26" @default.
- W2895838775 title "Thesis Abstract Psoriasis: Paraoxonase and Lipoprotein (a) Role" @default.
- W2895838775 doi "https://doi.org/10.32441/ijms.v1i3.104" @default.
- W2895838775 hasPublicationYear "2018" @default.
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