Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895840673> ?p ?o ?g. }
- W2895840673 abstract "Abstract Tuberculosis (TB) caused by Mycobacterium tuberculosis ( Mtb ) kills millions every year, and there is urgent need to develop novel anti-TB agents due to the fast-growing of drug-resistant TB. Although autophagy regulates the intracellular survival of Mtb , the role of calcium (Ca 2+ ) signaling in modulating autophagy during Mtb infection remains largely unknown. Here, we show that microRNA miR-27a is abundantly expressed in active TB patients, Mtb -infected mice and macrophages. The target of miR-27a is the ER-located Ca 2+ transporter CACNA2D3. Targeting of this transporter leads to the downregulation of Ca 2+ signaling, thus inhibiting autophagosome formation and promoting the intracellular survival of Mtb . Mice lacking of miR-27a and mice treated with an antagomir to miR-27a are more resistant to Mtb infection. Our findings reveal a strategy for Mtb to increase intracellular survival by manipulating the Ca 2+ -associated autophagy, and may also support the development of host-directed anti-TB therapeutic approaches." @default.
- W2895840673 created "2018-10-26" @default.
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- W2895840673 date "2018-10-16" @default.
- W2895840673 modified "2023-10-17" @default.
- W2895840673 title "MicroRNA-27a controls the intracellular survival of Mycobacterium tuberculosis by regulating calcium-associated autophagy" @default.
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- W2895840673 doi "https://doi.org/10.1038/s41467-018-06836-4" @default.
- W2895840673 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6191460" @default.
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