FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895840832> ?p ?o ?g. }

• W2895840832 abstract "General control non-derepressible 5 (GCN5) is ectopically expressed in different types of human cancer and association with the carcinogenesis, development, and poor prognosis of cancers. The present study was aimed to investigate the potential role and related mechanisms of GCN5 in IL-6–treated prostate cancer (PCa) cell. The results showed that an elevated GCN5 expression was stimulated by IL-6. Knockdown of GCN5 significantly inhibited IL-6–driven proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT). Moreover, early growth response-1 (Egr-1) expression was elevated by IL-6 treatment and GCN5 siRNA down-regulated the expression of Egr-1. Furthermore, overexpression of Egr-1 attenuated the effects of GCN5 silence on cell proliferation, migration, invasion, and EMT in PCa. Besides, knockdown of GCN5 resulted in the down-regulation of p-Akt and up-regulation of PTEN, which was partly impeded by Egr-1 overexpression. The effects of GCN5 overexpression on cell proliferation and invasion were suppressed by LY294002, In conclusion, these data demonstrated the negative effect of up-regulated GCN5 in IL-6-induced metastasis and EMT in PCa cells through PI3K/PTEN/Akt signaling pathway down-regulating Egr-1 expression." @default.
• W2895840832 created "2018-10-26" @default.
• W2895840832 creator A5007275423 @default.
• W2895840832 creator A5027311139 @default.
• W2895840832 creator A5035523819 @default.
• W2895840832 creator A5066685111 @default.
• W2895840832 creator A5082529649 @default.
• W2895840832 creator A5088821585 @default.
• W2895840832 date "2018-11-30" @default.
• W2895840832 modified "2023-10-03" @default.
• W2895840832 title "GCN5 inhibition prevents IL-6-induced prostate cancer metastases through PI3K/PTEN/Akt signaling by inactivating Egr-1" @default.
• W2895840832 cites W100143147 @default.
• W2895840832 cites W1545242926 @default.
• W2895840832 cites W1550596914 @default.
• W2895840832 cites W1569416291 @default.
• W2895840832 cites W1581834767 @default.
• W2895840832 cites W1911919368 @default.
• W2895840832 cites W1943161153 @default.
• W2895840832 cites W1988444883 @default.
• W2895840832 cites W1990302968 @default.
• W2895840832 cites W2033286803 @default.
• W2895840832 cites W2035946716 @default.
• W2895840832 cites W2036278849 @default.
• W2895840832 cites W2048601897 @default.
• W2895840832 cites W2058104153 @default.
• W2895840832 cites W2062974833 @default.
• W2895840832 cites W2066213591 @default.
• W2895840832 cites W2081662078 @default.
• W2895840832 cites W2093048712 @default.
• W2895840832 cites W2115742485 @default.
• W2895840832 cites W2130009954 @default.
• W2895840832 cites W2153831004 @default.
• W2895840832 cites W2156617735 @default.
• W2895840832 cites W2158074192 @default.
• W2895840832 cites W2161817637 @default.
• W2895840832 cites W2163764443 @default.
• W2895840832 cites W2165775087 @default.
• W2895840832 cites W2181441405 @default.
• W2895840832 cites W2211387700 @default.
• W2895840832 cites W2292490918 @default.
• W2895840832 cites W2330745933 @default.
• W2895840832 cites W2498723612 @default.
• W2895840832 cites W2577052402 @default.
• W2895840832 cites W2582916900 @default.
• W2895840832 cites W2613222885 @default.
• W2895840832 cites W2731960028 @default.
• W2895840832 cites W2734861305 @default.
• W2895840832 cites W2769393039 @default.
• W2895840832 cites W2789473119 @default.
• W2895840832 doi "https://doi.org/10.1042/bsr20180816" @default.
• W2895840832 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6265619" @default.
• W2895840832 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30333255" @default.
• W2895840832 hasPublicationYear "2018" @default.
• W2895840832 type Work @default.
• W2895840832 sameAs 2895840832 @default.
• W2895840832 citedByCount "19" @default.
• W2895840832 countsByYear W28958408322019 @default.
• W2895840832 countsByYear W28958408322020 @default.
• W2895840832 countsByYear W28958408322021 @default.
• W2895840832 countsByYear W28958408322022 @default.
• W2895840832 countsByYear W28958408322023 @default.
• W2895840832 crossrefType "journal-article" @default.
• W2895840832 hasAuthorship W2895840832A5007275423 @default.
• W2895840832 hasAuthorship W2895840832A5027311139 @default.
• W2895840832 hasAuthorship W2895840832A5035523819 @default.
• W2895840832 hasAuthorship W2895840832A5066685111 @default.
• W2895840832 hasAuthorship W2895840832A5082529649 @default.
• W2895840832 hasAuthorship W2895840832A5088821585 @default.
• W2895840832 hasBestOaLocation W28958408321 @default.
• W2895840832 hasConcept C121608353 @default.
• W2895840832 hasConcept C126322002 @default.
• W2895840832 hasConcept C137738243 @default.
• W2895840832 hasConcept C1491633281 @default.
• W2895840832 hasConcept C173396325 @default.
• W2895840832 hasConcept C185592680 @default.
• W2895840832 hasConcept C190283241 @default.
• W2895840832 hasConcept C2776912716 @default.
• W2895840832 hasConcept C2777609662 @default.
• W2895840832 hasConcept C2779013556 @default.
• W2895840832 hasConcept C2780192828 @default.
• W2895840832 hasConcept C502942594 @default.
• W2895840832 hasConcept C54355233 @default.
• W2895840832 hasConcept C55493867 @default.
• W2895840832 hasConcept C555283112 @default.
• W2895840832 hasConcept C62112901 @default.
• W2895840832 hasConcept C62478195 @default.
• W2895840832 hasConcept C71924100 @default.
• W2895840832 hasConcept C75217442 @default.
• W2895840832 hasConcept C86554907 @default.
• W2895840832 hasConcept C86803240 @default.
• W2895840832 hasConcept C95444343 @default.
• W2895840832 hasConceptScore W2895840832C121608353 @default.
• W2895840832 hasConceptScore W2895840832C126322002 @default.
• W2895840832 hasConceptScore W2895840832C137738243 @default.
• W2895840832 hasConceptScore W2895840832C1491633281 @default.
• W2895840832 hasConceptScore W2895840832C173396325 @default.
• W2895840832 hasConceptScore W2895840832C185592680 @default.
• W2895840832 hasConceptScore W2895840832C190283241 @default.
• W2895840832 hasConceptScore W2895840832C2776912716 @default.
• W2895840832 hasConceptScore W2895840832C2777609662 @default.

• next