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- W2895842235 abstract "Background and PurposeDamage to corneal tissue results in intense ocular pain, dysfunction in nociceptive signaling and release of inflammatory mediators. Current treatments for corneal pain and inflammation are frequently ineffective. The endocannabinoid system (ECS) is an emerging therapeutic target in the modulation of pain and inflammation. The ECS consists of endogenous cannabinoid ligands that mediate their actions via G-protein coupled receptors, cannabinoid 1 receptor (CB1R) and cannabinoid 2 receptor (CB2R). Cannabinoids that bind to CB1R, like tetrahydrocannabinol (THC), have shown utility in treating pain, however, their therapeutic applications are limited by CB1R-mediated behavioral side-effects. The non-psychoactive phytocannabinoid, cannabidiol (CBD), and CBD derivatives, CBD-DMH and HU-308, have reported anti-inflammatory effects, which may be mediated independent of CB1R, and could offer an alternative to CB1R ligands in the treatment of ocular pain and inflammation. Therefore, the purpos..." @default.
- W2895842235 created "2018-10-26" @default.
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- W2895842235 date "2017-04-01" @default.
- W2895842235 modified "2023-10-03" @default.
- W2895842235 title "The Non-psychoactive Phytocannabinoid, Cannabidiol (CBD), and the Synthetic Derivatives, HU308 and CBD-DMH, Reduces Hyperalgesia and Inflammation in a Mouse Model of Corneal injury." @default.
- W2895842235 doi "https://doi.org/10.1096/fasebj.31.1_supplement.811.7" @default.
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