FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895844946> ?p ?o ?g. }

• W2895844946 endingPage "200" @default.
• W2895844946 startingPage "188" @default.
• W2895844946 abstract "Abstract Purpose: The inability to intraoperatively distinguish primary tumor, as well as lymphatic spread, increases the probability of positive surgical margins, tumor recurrence, and surgical toxicity. The goal of this study was to develop a tumor-specific optical probe for real-time fluorescence-guided surgery. Experimental Design: A humanized antibody fragment against PSCA (A11 minibody, A11 Mb) was conjugated with a near-infrared fluorophore, IRDye800CW. The integrity and binding of the probe to PSCA were confirmed by gel electrophoresis, size-exclusion chromatography, and flow cytometry, respectively. The ability of the probe to detect tumor-infiltrated lymph nodes and metastatic lesions was evaluated in 2 xenograft models, as well as in transgenic mice expressing human PSCA (hPSCA). An invasive intramuscular model was utilized to evaluate the efficacy of the A11 Mb-IRDye800CW-guided surgery. Results: A11 Mb was successfully conjugated with IRDye800CW and retained specific binding to PSCA. In vivo imaging showed maximal signal-to-background ratios at 48 hours. The A11 Mb-IRDye800CW specifically detected PSCA-positive primary tumors, tumor-infiltrated lymph nodes, and distant metastases with high contrast. Fluorescence guidance facilitated more complete tumor resection, reduced tumor recurrence, and improved overall survival, compared with conventional white light surgery. The probe successfully identified primary orthotopic tumors and metastatic lesions in hPSCA transgenic mice. Conclusions: Real-time fluorescence image–guided surgery with A11 Mb-IRDye800CW enabled detection of lymph node metastases and positive surgical margins, facilitated more complete tumor removal, and improved survival, compared with white light surgery. These results may be translatable into clinical practice to improve surgical and patient outcomes." @default.
• W2895844946 created "2018-10-26" @default.
• W2895844946 creator A5001391460 @default.
• W2895844946 creator A5030161456 @default.
• W2895844946 creator A5034028155 @default.
• W2895844946 creator A5058192744 @default.
• W2895844946 creator A5064375754 @default.
• W2895844946 creator A5065591292 @default.
• W2895844946 creator A5066301854 @default.
• W2895844946 creator A5071756455 @default.
• W2895844946 creator A5073684381 @default.
• W2895844946 creator A5083611896 @default.
• W2895844946 creator A5087591232 @default.
• W2895844946 creator A5090419455 @default.
• W2895844946 date "2019-01-01" @default.
• W2895844946 modified "2023-09-26" @default.
• W2895844946 title "Near-Infrared Dye-Labeled Anti-Prostate Stem Cell Antigen Minibody Enables Real-Time Fluorescence Imaging and Targeted Surgery in Translational Mouse Models" @default.
• W2895844946 cites W1183160464 @default.
• W2895844946 cites W1541733924 @default.
• W2895844946 cites W1606943714 @default.
• W2895844946 cites W1963595566 @default.
• W2895844946 cites W1976569516 @default.
• W2895844946 cites W1977030260 @default.
• W2895844946 cites W1982544588 @default.
• W2895844946 cites W1993230164 @default.
• W2895844946 cites W1993575340 @default.
• W2895844946 cites W1997285645 @default.
• W2895844946 cites W2006912346 @default.
• W2895844946 cites W2007254023 @default.
• W2895844946 cites W2009345208 @default.
• W2895844946 cites W2027236201 @default.
• W2895844946 cites W2034466306 @default.
• W2895844946 cites W2035271331 @default.
• W2895844946 cites W2040608788 @default.
• W2895844946 cites W2048570741 @default.
• W2895844946 cites W2053088103 @default.
• W2895844946 cites W2059233961 @default.
• W2895844946 cites W2106235642 @default.
• W2895844946 cites W2111333477 @default.
• W2895844946 cites W2113098018 @default.
• W2895844946 cites W2121167328 @default.
• W2895844946 cites W2127212225 @default.
• W2895844946 cites W2133632925 @default.
• W2895844946 cites W2134019417 @default.
• W2895844946 cites W2141197943 @default.
• W2895844946 cites W2145564958 @default.
• W2895844946 cites W2191207157 @default.
• W2895844946 cites W2207385770 @default.
• W2895844946 cites W2235523093 @default.
• W2895844946 cites W2275565843 @default.
• W2895844946 cites W2421919823 @default.
• W2895844946 cites W2508622292 @default.
• W2895844946 cites W2552088672 @default.
• W2895844946 cites W2554295594 @default.
• W2895844946 cites W2731354724 @default.
• W2895844946 cites W2747376235 @default.
• W2895844946 cites W2755748742 @default.
• W2895844946 cites W2795159517 @default.
• W2895844946 doi "https://doi.org/10.1158/1078-0432.ccr-18-1382" @default.
• W2895844946 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6559730" @default.
• W2895844946 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30301826" @default.
• W2895844946 hasPublicationYear "2019" @default.
• W2895844946 type Work @default.
• W2895844946 sameAs 2895844946 @default.
• W2895844946 citedByCount "21" @default.
• W2895844946 countsByYear W28958449462019 @default.
• W2895844946 countsByYear W28958449462020 @default.
• W2895844946 countsByYear W28958449462021 @default.
• W2895844946 countsByYear W28958449462022 @default.
• W2895844946 crossrefType "journal-article" @default.
• W2895844946 hasAuthorship W2895844946A5001391460 @default.
• W2895844946 hasAuthorship W2895844946A5030161456 @default.
• W2895844946 hasAuthorship W2895844946A5034028155 @default.
• W2895844946 hasAuthorship W2895844946A5058192744 @default.
• W2895844946 hasAuthorship W2895844946A5064375754 @default.
• W2895844946 hasAuthorship W2895844946A5065591292 @default.
• W2895844946 hasAuthorship W2895844946A5066301854 @default.
• W2895844946 hasAuthorship W2895844946A5071756455 @default.
• W2895844946 hasAuthorship W2895844946A5073684381 @default.
• W2895844946 hasAuthorship W2895844946A5083611896 @default.
• W2895844946 hasAuthorship W2895844946A5087591232 @default.
• W2895844946 hasAuthorship W2895844946A5090419455 @default.
• W2895844946 hasBestOaLocation W28958449461 @default.
• W2895844946 hasConcept C121608353 @default.
• W2895844946 hasConcept C126322002 @default.
• W2895844946 hasConcept C142724271 @default.
• W2895844946 hasConcept C150903083 @default.
• W2895844946 hasConcept C181152851 @default.
• W2895844946 hasConcept C203014093 @default.
• W2895844946 hasConcept C207001950 @default.
• W2895844946 hasConcept C26291073 @default.
• W2895844946 hasConcept C2779013556 @default.
• W2895844946 hasConcept C2779720271 @default.
• W2895844946 hasConcept C2780283643 @default.
• W2895844946 hasConcept C2780849966 @default.
• W2895844946 hasConcept C502942594 @default.
• W2895844946 hasConcept C553184892 @default.
• W2895844946 hasConcept C71924100 @default.

• next