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• W2895848491 abstract "<h3>Objectives:</h3> To determine the distribution and resistance profiles of Gram-negative bacteria (GNB) in intensive care units (ICUs) at King Abdullah Hospital in Bisha, Saudi Arabia. <h3>Methods:</h3> A record based retrospective study was conducted from December 2016 to January 2018. In total, 3736 non-duplicate clinical specimens from the general intensive care unit (ICU), neonatal ICU (NICU), and coronary CU (CCU) were analyzed for pathogens. <h3>Results:</h3> Of 3736 specimens, 9.6% (358) were positive for pathogens, and GNB constituted the majority (290/358; 81%). <i>Acinetobacter</i> is predominant in the general ICU, whereas <i>Klebsiella pneumoniae</i> is common in the NICU and CCU. Overall, GNB revealed a high resistance rate for cefuroxime (75.8%) trimethoprim/sulfamethoxazole (73.4%), cefotaxime (72.9%), aztreonam (64.6%), piperacillin (62.1%), and ciprofloxacin (61.5%). <i>Acinetobacter</i> revealed a high resistance (93.4% to 97.5%) to all antimicrobials except colistin (4%). <i>Klebsiella pneumoniae</i> showed a high resistance to trimethoprim/sulfamethoxazole (71.8%), cefotaxime (71.4%) and aztreonam (65.2%). <i>Pseudomonas aeruginosa</i> showed good activity for aminoglycosides but increasing resistance for cephalosporins and meropenem. GNB exhibited a high rate of multi-drug-resistant (MDR) phenotypes (67.9%) with a higher level among <i>Acinetobacter spp</i>. (97.5%). There were no significant differences in the resistance rates of GNB from different ICUs except for imipenem (<i>p</i>=0.002) and ciprofloxacin (<i>p</i>=0.003). <h3>Conclusions:</h3> Increased antimicrobial resistance with high proportions of MDR patterns were found among GNB from ICUs. Comprehensive surveillance programs are needed to track the origins and emergence pathways of resistant pathogens." @default.
• W2895848491 created "2018-10-26" @default.
• W2895848491 creator A5003723264 @default.
• W2895848491 date "2018-10-01" @default.
• W2895848491 modified "2023-09-27" @default.
• W2895848491 title "High antimicrobial resistant rates among Gram-negative pathogens in intensive care units" @default.
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• W2895848491 doi "https://doi.org/10.15537/smj.2018.10.22944" @default.
• W2895848491 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6201019" @default.
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