Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895850697> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2895850697 abstract "Menopause is associated with subjective cognitive decline (SCD) and older women are at increased risk of developing Alzheimer's disease compared to men. One proposed reason for cognitive changes following menopause is the loss of estrogen support. Estrogen has been shown to be important for cholinergic functioning, with our prior work showing that estrogen treatment in postmenopausal women attenuates the impact of cholinergic antagonists on cognitive performance. There is evidence that women with greater SCD are at a higher risk of developing MCI and AD. This study investigated the effect of estradiol treatment on cognitive performance in postmenopausal women with SCD. 56 early postmenopausal women (aged 50-60 years) with differing levels of SCD completed a 3 month treatment regimen of either 1 mg oral 17β-estradiol or placebo. Participants then completed four challenge days in which they completed cognitive and behavioral tasks after one of four cholinergic antagonist drug conditions (oral mecamylamine, intravenous scopolamine, combined mecamylamine and scopolamine or placebo). The cognitive tasks assessed included the Buschke selective reminding task, associative recognition task, choice reaction time task (CRT), critical flicker fusion task (CFF) and the Posner spatial attention task. All participants performed worse under cholinergic challenge compared to placebo; however participants who received 3 months of estradiol treatment did not show blunting of anticholinergic blockade compared to participants who received placebo. There was no difference between estradiol and placebo groups on the Posner or associative recognition tasks. Moreover, recognition scores on both the CFF and CRT significantly favored participants who received placebo over estradiol. The results of this study show that estradiol intervention did not mitigate the effect of anticholinergic drugs on cognitive performance. Compared to previous studies the sample of women in this study was both younger and more homogenous in age, and this may limit the impact of the estradiol treatment. These results are consistent with the findings of a recent structural MRI analysis, which showed that women with SCD had deterioration in hippocampus but not in areas with large numbers of cholinergic neurons, such as the basal forebrain." @default.
- W2895850697 created "2018-10-26" @default.
- W2895850697 creator A5019605511 @default.
- W2895850697 creator A5023112291 @default.
- W2895850697 creator A5043856481 @default.
- W2895850697 creator A5053733868 @default.
- W2895850697 creator A5075819305 @default.
- W2895850697 creator A5082289456 @default.
- W2895850697 date "2018-07-01" @default.
- W2895850697 modified "2023-10-16" @default.
- W2895850697 title "P1‐045: ESTROGEN TREATMENT IN YOUNG POSTMENOPAUSAL WOMEN WITH SUBJECTIVE COGNITIVE DECLINE DOES NOT MITIGATE ANTICHOLINERGIC EFFECTS ON COGNITIVE PERFORMANCE" @default.
- W2895850697 doi "https://doi.org/10.1016/j.jalz.2018.06.046" @default.
- W2895850697 hasPublicationYear "2018" @default.
- W2895850697 type Work @default.
- W2895850697 sameAs 2895850697 @default.
- W2895850697 citedByCount "0" @default.
- W2895850697 crossrefType "journal-article" @default.
- W2895850697 hasAuthorship W2895850697A5019605511 @default.
- W2895850697 hasAuthorship W2895850697A5023112291 @default.
- W2895850697 hasAuthorship W2895850697A5043856481 @default.
- W2895850697 hasAuthorship W2895850697A5053733868 @default.
- W2895850697 hasAuthorship W2895850697A5075819305 @default.
- W2895850697 hasAuthorship W2895850697A5082289456 @default.
- W2895850697 hasConcept C118552586 @default.
- W2895850697 hasConcept C126322002 @default.
- W2895850697 hasConcept C142724271 @default.
- W2895850697 hasConcept C15744967 @default.
- W2895850697 hasConcept C169900460 @default.
- W2895850697 hasConcept C185711340 @default.
- W2895850697 hasConcept C204787440 @default.
- W2895850697 hasConcept C22885893 @default.
- W2895850697 hasConcept C27081682 @default.
- W2895850697 hasConcept C2777164284 @default.
- W2895850697 hasConcept C2778562196 @default.
- W2895850697 hasConcept C2778689640 @default.
- W2895850697 hasConcept C2779134260 @default.
- W2895850697 hasConcept C2779483572 @default.
- W2895850697 hasConcept C2984863031 @default.
- W2895850697 hasConcept C71924100 @default.
- W2895850697 hasConceptScore W2895850697C118552586 @default.
- W2895850697 hasConceptScore W2895850697C126322002 @default.
- W2895850697 hasConceptScore W2895850697C142724271 @default.
- W2895850697 hasConceptScore W2895850697C15744967 @default.
- W2895850697 hasConceptScore W2895850697C169900460 @default.
- W2895850697 hasConceptScore W2895850697C185711340 @default.
- W2895850697 hasConceptScore W2895850697C204787440 @default.
- W2895850697 hasConceptScore W2895850697C22885893 @default.
- W2895850697 hasConceptScore W2895850697C27081682 @default.
- W2895850697 hasConceptScore W2895850697C2777164284 @default.
- W2895850697 hasConceptScore W2895850697C2778562196 @default.
- W2895850697 hasConceptScore W2895850697C2778689640 @default.
- W2895850697 hasConceptScore W2895850697C2779134260 @default.
- W2895850697 hasConceptScore W2895850697C2779483572 @default.
- W2895850697 hasConceptScore W2895850697C2984863031 @default.
- W2895850697 hasConceptScore W2895850697C71924100 @default.
- W2895850697 hasIssue "7S_Part_5" @default.
- W2895850697 hasLocation W28958506971 @default.
- W2895850697 hasOpenAccess W2895850697 @default.
- W2895850697 hasPrimaryLocation W28958506971 @default.
- W2895850697 hasRelatedWork W182016951 @default.
- W2895850697 hasRelatedWork W2064114605 @default.
- W2895850697 hasRelatedWork W2070165017 @default.
- W2895850697 hasRelatedWork W2077992747 @default.
- W2895850697 hasRelatedWork W2098061129 @default.
- W2895850697 hasRelatedWork W2561267217 @default.
- W2895850697 hasRelatedWork W3017193929 @default.
- W2895850697 hasRelatedWork W4308498428 @default.
- W2895850697 hasRelatedWork W4320711771 @default.
- W2895850697 hasRelatedWork W4379621630 @default.
- W2895850697 hasVolume "14" @default.
- W2895850697 isParatext "false" @default.
- W2895850697 isRetracted "false" @default.
- W2895850697 magId "2895850697" @default.
- W2895850697 workType "article" @default.