Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895854258> ?p ?o ?g. }
- W2895854258 endingPage "9783" @default.
- W2895854258 startingPage "9756" @default.
- W2895854258 abstract "In recent years, channels that mediate store-operated calcium entry (SOCE, i.e., the ability of cells to sense a decrease in endoplasmic reticulum luminal calcium and induce calcium entry across the plasma membrane) have been associated with a number of disorders, spanning from immune disorders to acute pancreatitis and have been suggested to be druggable targets. In the present contribution, we exploited the click chemistry approach to synthesize a class of SOCE modulators where the arylamide substructure that characterizes most inhibitors so far described is substituted by a 1,4-disubstituted 1,2,3-triazole ring. Within this series, inhibitors of SOCE were identified and the best compound proved effective in an animal model of acute pancreatitis, a disease characterized by a hyperactivation of SOCE. Strikingly, two enhancers of the process were discovered, affording invaluable research tools to further explore the (patho)physiological role of capacitative calcium entry." @default.
- W2895854258 created "2018-10-26" @default.
- W2895854258 creator A5000329987 @default.
- W2895854258 creator A5003881266 @default.
- W2895854258 creator A5015004553 @default.
- W2895854258 creator A5018232279 @default.
- W2895854258 creator A5019743956 @default.
- W2895854258 creator A5022376648 @default.
- W2895854258 creator A5024096995 @default.
- W2895854258 creator A5043265559 @default.
- W2895854258 creator A5045982781 @default.
- W2895854258 creator A5053839749 @default.
- W2895854258 creator A5063907700 @default.
- W2895854258 creator A5067052705 @default.
- W2895854258 creator A5072062654 @default.
- W2895854258 creator A5076323717 @default.
- W2895854258 creator A5080780327 @default.
- W2895854258 creator A5082181425 @default.
- W2895854258 creator A5090830510 @default.
- W2895854258 creator A5091093273 @default.
- W2895854258 date "2018-10-22" @default.
- W2895854258 modified "2023-09-30" @default.
- W2895854258 title "Pyrtriazoles, a Novel Class of Store-Operated Calcium Entry Modulators: Discovery, Biological Profiling, and in Vivo Proof-of-Concept Efficacy in Acute Pancreatitis" @default.
- W2895854258 cites W1493270913 @default.
- W2895854258 cites W1554199623 @default.
- W2895854258 cites W1568400196 @default.
- W2895854258 cites W1579848174 @default.
- W2895854258 cites W1599277155 @default.
- W2895854258 cites W1795554797 @default.
- W2895854258 cites W182409224 @default.
- W2895854258 cites W1935830997 @default.
- W2895854258 cites W1964158609 @default.
- W2895854258 cites W1966994683 @default.
- W2895854258 cites W1967218656 @default.
- W2895854258 cites W1969750265 @default.
- W2895854258 cites W1970629236 @default.
- W2895854258 cites W1970899777 @default.
- W2895854258 cites W1985785210 @default.
- W2895854258 cites W1986531910 @default.
- W2895854258 cites W1996387672 @default.
- W2895854258 cites W2000563705 @default.
- W2895854258 cites W2006657887 @default.
- W2895854258 cites W2015080011 @default.
- W2895854258 cites W2015480034 @default.
- W2895854258 cites W2019825847 @default.
- W2895854258 cites W2021569813 @default.
- W2895854258 cites W2023571093 @default.
- W2895854258 cites W2029921511 @default.
- W2895854258 cites W2029953646 @default.
- W2895854258 cites W2032770343 @default.
- W2895854258 cites W2036413106 @default.
- W2895854258 cites W2037289981 @default.
- W2895854258 cites W2041383551 @default.
- W2895854258 cites W2043519102 @default.
- W2895854258 cites W2046470310 @default.
- W2895854258 cites W2050443418 @default.
- W2895854258 cites W2050518296 @default.
- W2895854258 cites W2057294527 @default.
- W2895854258 cites W2059829735 @default.
- W2895854258 cites W2061174398 @default.
- W2895854258 cites W2070832223 @default.
- W2895854258 cites W2079071687 @default.
- W2895854258 cites W2086640970 @default.
- W2895854258 cites W2096952782 @default.
- W2895854258 cites W2109745844 @default.
- W2895854258 cites W2122373218 @default.
- W2895854258 cites W2136448440 @default.
- W2895854258 cites W2161210718 @default.
- W2895854258 cites W2174907417 @default.
- W2895854258 cites W2345685532 @default.
- W2895854258 cites W2489951305 @default.
- W2895854258 cites W2569357467 @default.
- W2895854258 cites W2587382717 @default.
- W2895854258 cites W2751623104 @default.
- W2895854258 cites W2761329663 @default.
- W2895854258 cites W2799833157 @default.
- W2895854258 cites W2884136317 @default.
- W2895854258 cites W4211040987 @default.
- W2895854258 cites W2047029475 @default.
- W2895854258 doi "https://doi.org/10.1021/acs.jmedchem.8b01512" @default.
- W2895854258 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30347159" @default.
- W2895854258 hasPublicationYear "2018" @default.
- W2895854258 type Work @default.
- W2895854258 sameAs 2895854258 @default.
- W2895854258 citedByCount "21" @default.
- W2895854258 countsByYear W28958542582019 @default.
- W2895854258 countsByYear W28958542582020 @default.
- W2895854258 countsByYear W28958542582021 @default.
- W2895854258 countsByYear W28958542582022 @default.
- W2895854258 countsByYear W28958542582023 @default.
- W2895854258 crossrefType "journal-article" @default.
- W2895854258 hasAuthorship W2895854258A5000329987 @default.
- W2895854258 hasAuthorship W2895854258A5003881266 @default.
- W2895854258 hasAuthorship W2895854258A5015004553 @default.
- W2895854258 hasAuthorship W2895854258A5018232279 @default.
- W2895854258 hasAuthorship W2895854258A5019743956 @default.
- W2895854258 hasAuthorship W2895854258A5022376648 @default.
- W2895854258 hasAuthorship W2895854258A5024096995 @default.