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- W2895854469 abstract "Background: the subject of herbal remedy has attracted a lot of attention in common health fields, namely burn wounds.Pistacia vera (P. vera), being from the family of Anacardiaceae, possesses several important pharmacological properties. In thisstudy, we aim at determining the healing effect of P. vera oil (topical administration) on the second-degree burn wound modelof rats.Materials and methods: After the induction of the second-degree burn wounds in the anesthetized animals using the hotplate, P. vera ointment was administered topically (5% and 10%) for three weeks in two groups of animals. Other groups weretreated with dexpanthenol or base cream for three weeks. Macroscopic and histological assessments were made to analyze thewound healing process.Results: data collected revealed that animals treated with P. vera 10% after 12 days of treatment showed significant repairin comparison with P. vera 5% or dexpanthenol. Moreover, after 22 days of the topical therapy, there was not any scar of woundson animal skins which were under the treatment of P. vera 10%. Histological assessments showed that treatment with P. veraointment is accompanied with a normal collagen deposition in the reticular layer as well as repaired epithelium in comparisonwith the base cream (p<0.01 for P. vera 5% and p<0.001 for P. vera 10%; in both parameters).Conclusion: P. vera topical dosage forms may be effective treatments for the second-degree burn wounds, yet more studiesare required to confirm the safety and possible repairing mechanisms." @default.
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- W2895854469 date "2018-06-01" @default.
- W2895854469 modified "2023-10-18" @default.
- W2895854469 title "The effects of the topical administration of Pistacia vera oil on the second-degree burn model in rats" @default.
- W2895854469 doi "https://doi.org/10.22123/phj.2018.115685.1003" @default.
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