FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895856179> ?p ?o ?g. }

• W2895856179 abstract "Abstract Mitochondrial morphology is remodeled by continuous dynamic cycles of fission and fusion. Emerging data have shown that the disturbance of balance between mitochondrial fission and fusion is involved in the progression of several types of neoplasms. However, the status of mitochondrial dynamics and its potential biological roles in breast cancer (BC), particularly in triple negative BC (TNBC) are not fully clear. Here, we reported that the mitochondrial fission was significantly increased in BC tissues, especially in the TNBC tissues, when compared with that in the corresponding peritumor tissues. Meanwhile, our data showed that Drp1 was upregulated, while Mfn1 was downregulated in TNBC. Moreover, elevated mitochondrial fission was associated with poorer prognosis in TNBC patients. Mitochondrial fission promoted the survival of TNBC cells both in vitro and in vivo. Furthermore, we identified a positive feedback loop between mitochondrial fission and Notch signaling pathway in TNBC cells, as proved by the experimental evidence that the activation of Notch signaling enhanced Drp1-mediated mitochondrial fission and Drp1-mediated mitochondrial fission in turn promoted the activation of Notch signaling, which ultimately promoted the cell survival of TNBC via increasing survivin expression level. Inhibition of either Notch1 or Drp1 significantly impaired the activation of the other, leading to the suppression of TNBC cell survival and proliferation. Collectively, our data reveal a novel mechanism that the positive feedback loop between mitochondrial fission and Notch signaling promotes the survival, proliferation and apoptotic resistance of TNBC cells via increasing survivin expression and thus favors cancer progression." @default.
• W2895856179 created "2018-10-26" @default.
• W2895856179 creator A5002710972 @default.
• W2895856179 creator A5009138463 @default.
• W2895856179 creator A5018161360 @default.
• W2895856179 creator A5018755589 @default.
• W2895856179 creator A5033269841 @default.
• W2895856179 creator A5036177016 @default.
• W2895856179 creator A5037989560 @default.
• W2895856179 creator A5047460165 @default.
• W2895856179 creator A5059751095 @default.
• W2895856179 creator A5067244371 @default.
• W2895856179 creator A5074907143 @default.
• W2895856179 creator A5078844871 @default.
• W2895856179 creator A5085242835 @default.
• W2895856179 date "2018-10-15" @default.
• W2895856179 modified "2023-10-16" @default.
• W2895856179 title "Positive feedback loop between mitochondrial fission and Notch signaling promotes survivin-mediated survival of TNBC cells" @default.
• W2895856179 cites W1503830687 @default.
• W2895856179 cites W1840701820 @default.
• W2895856179 cites W1951931393 @default.
• W2895856179 cites W1964720708 @default.
• W2895856179 cites W1969466871 @default.
• W2895856179 cites W1969666568 @default.
• W2895856179 cites W1973569665 @default.
• W2895856179 cites W1976770854 @default.
• W2895856179 cites W1984365236 @default.
• W2895856179 cites W1989867410 @default.
• W2895856179 cites W1995025616 @default.
• W2895856179 cites W2007185928 @default.
• W2895856179 cites W2007508922 @default.
• W2895856179 cites W2011100088 @default.
• W2895856179 cites W2015580541 @default.
• W2895856179 cites W2041851797 @default.
• W2895856179 cites W2049223018 @default.
• W2895856179 cites W2064570455 @default.
• W2895856179 cites W2074617654 @default.
• W2895856179 cites W2078374613 @default.
• W2895856179 cites W2080316304 @default.
• W2895856179 cites W2115504447 @default.
• W2895856179 cites W2116709318 @default.
• W2895856179 cites W2124549066 @default.
• W2895856179 cites W2124812632 @default.
• W2895856179 cites W2131994307 @default.
• W2895856179 cites W2133977960 @default.
• W2895856179 cites W2136937485 @default.
• W2895856179 cites W2139131640 @default.
• W2895856179 cites W2140374331 @default.
• W2895856179 cites W2142920152 @default.
• W2895856179 cites W2146074268 @default.
• W2895856179 cites W2152979067 @default.
• W2895856179 cites W2156523607 @default.
• W2895856179 cites W2159864138 @default.
• W2895856179 cites W2160483366 @default.
• W2895856179 cites W2161291398 @default.
• W2895856179 cites W2161320489 @default.
• W2895856179 cites W2167542517 @default.
• W2895856179 cites W2168035834 @default.
• W2895856179 cites W2170527014 @default.
• W2895856179 cites W2171278822 @default.
• W2895856179 cites W2344007450 @default.
• W2895856179 cites W2577310139 @default.
• W2895856179 cites W2746741726 @default.
• W2895856179 cites W2762481118 @default.
• W2895856179 cites W2766798749 @default.
• W2895856179 cites W2773501033 @default.
• W2895856179 cites W2791090958 @default.
• W2895856179 cites W952105760 @default.
• W2895856179 doi "https://doi.org/10.1038/s41419-018-1083-y" @default.
• W2895856179 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6189045" @default.
• W2895856179 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30323195" @default.
• W2895856179 hasPublicationYear "2018" @default.
• W2895856179 type Work @default.
• W2895856179 sameAs 2895856179 @default.
• W2895856179 citedByCount "42" @default.
• W2895856179 countsByYear W28958561792019 @default.
• W2895856179 countsByYear W28958561792020 @default.
• W2895856179 countsByYear W28958561792021 @default.
• W2895856179 countsByYear W28958561792022 @default.
• W2895856179 countsByYear W28958561792023 @default.
• W2895856179 crossrefType "journal-article" @default.
• W2895856179 hasAuthorship W2895856179A5002710972 @default.
• W2895856179 hasAuthorship W2895856179A5009138463 @default.
• W2895856179 hasAuthorship W2895856179A5018161360 @default.
• W2895856179 hasAuthorship W2895856179A5018755589 @default.
• W2895856179 hasAuthorship W2895856179A5033269841 @default.
• W2895856179 hasAuthorship W2895856179A5036177016 @default.
• W2895856179 hasAuthorship W2895856179A5037989560 @default.
• W2895856179 hasAuthorship W2895856179A5047460165 @default.
• W2895856179 hasAuthorship W2895856179A5059751095 @default.
• W2895856179 hasAuthorship W2895856179A5067244371 @default.
• W2895856179 hasAuthorship W2895856179A5074907143 @default.
• W2895856179 hasAuthorship W2895856179A5078844871 @default.
• W2895856179 hasAuthorship W2895856179A5085242835 @default.
• W2895856179 hasBestOaLocation W28958561791 @default.
• W2895856179 hasConcept C104317684 @default.
• W2895856179 hasConcept C121332964 @default.
• W2895856179 hasConcept C12294094 @default.
• W2895856179 hasConcept C152568617 @default.
• W2895856179 hasConcept C161879069 @default.

• next