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- W2895858768 abstract "During sperm maturation, chromatin undergoes an extensive compaction through the progressive replacement of histones with basic, positively-charged proteins called protamines. Interestingly, in human and other vertebrates, 5–15% of the paternal genome retains a somatic-like structure. It has been suggested that preserved nucleosomes have a role in promoting transcription after fertilization, however their localization and function is still a matter of debate. The aim of the present work was to understand if the localization of histones in human sperm DNA is affected by genome composition, a feature linked to several biological functions. In order to do that, we mapped histone-enriched sequences along isochores, which are large chromosomal territories characterized by fairly homogeneous guanine and cytosine (GC) composition." @default.
- W2895858768 created "2018-10-26" @default.
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- W2895858768 date "2018-09-01" @default.
- W2895858768 modified "2023-09-25" @default.
- W2895858768 title "Distribution of Nucleosome-enriched Sequences of Human Sperm Chromatin Along Isochores" @default.
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- W2895858768 doi "https://doi.org/10.14218/erhm.2018.00009" @default.
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