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- W2895859253 abstract "Though the burden of brain amyloid-β (Aβ) is routinely estimated using mean cortical standardized uptake value ratio (SUVR) values derived from Aβ positron emission tomography (PET), increased sensitivity for the detection of Aβ burden has recently been shown using a novel outcome measure known as amyloid load (AβL). In order to generate AβL, an algorithm is applied in order to match canonical images derived from logistic growth modeling to a static PET image. In the present study, we aimed to investigate, using [18F]flutemetamol PET, whether a weighting factor (W) derived from an analogous principal component analysis (PCA) based normalization approach might provide an additional alternative to SUVR. 160 patients were included from the Department of Geriatric Medicine, Karolinska University Hospital, Huddinge, Sweden. [18F]Flutemetamol investigations were performed using a Biograph mCT PET/CT (Siemens/CTI, Knoxville, TN), with the acquisition protocol consisting of a static 20 min scan, 90 min post-injection of 185 MBq. In addition to visual assessment by an experienced nuclear medicine physician, [18F]flutemetamol uptake (SUVR) was quantified on a volume of interest (VOI) basis using a fully automated software (Hermes Medical Solutions). In addition, a W value was generated for each subject. Pearson product-moment correlation analysis was performed between W and SUVR values, along with the calculation of area under the receiver operating characteristic curve (AUC) and effect size for group separation (Aβ positive vs negative, visual read). Using a composite cortical VOI, a strong correlation was observed between SUVR and W (r=0.89). Group separation and effect size were comparable between both measures (AUC: SUVR=0.99, W=0.98; effect size SUVR=1.70, W=1.69). Using a sample representative of tertiary memory clinic populations, PCA derived W values proved an accurate method for estimation of brain Aβ burden. As W is both target and reference region independent, an advantage over SUVR, it may constitute a metric that is simpler to implement in clinical settings, especially in the context of anti-Aβ drug trials. Moreover, while further validation studies are required, the use of W could facilitate the comparison of findings across Aβ tracers/centers, as the Centiloid transformation would not need to be applied." @default.
- W2895859253 created "2018-10-26" @default.
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- W2895859253 date "2018-07-01" @default.
- W2895859253 modified "2023-10-16" @default.
- W2895859253 title "IC‐P‐016: ESTIMATION OF AMYLOID LOAD USING [ <sup>18</sup> F]FLUTEMETAMOL AND A NORMALIZATION DERIVED WEIGHTING FACTOR: POTENTIAL APPLICATIONS IN AMYLOID PET" @default.
- W2895859253 doi "https://doi.org/10.1016/j.jalz.2018.06.2080" @default.
- W2895859253 hasPublicationYear "2018" @default.
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