Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895860273> ?p ?o ?g. }
- W2895860273 endingPage "874.e5" @default.
- W2895860273 startingPage "862" @default.
- W2895860273 abstract "mRNAs carry two layers of information, the genetic code and the information that dictates their post-transcriptional fate. The latter function relies on a complex interplay between cis-elements and trans-regulators, and unbiased identification of these elements is still challenging. To identify cis-elements that control gene expression, we use dimethyl sulfate (DMS) mutational profiling with sequencing and map changes in mRNA secondary structure following viral infection. Our dynamic structural data reveal a major role for ribosomes in unwinding secondary structures, which is further supported by the relationship we uncover between structure and translation efficiency. Moreover, our analysis revealed dozens of regions in viral and cellular mRNAs that exhibit changes in secondary structure. In-depth analysis of these regions reveals cis-elements in 3′ UTRs that regulate mRNA stability and elements within coding sequences that control translation. Overall, our study demonstrates how mapping dynamic changes in mRNA structure allows unbiased identification of functional regulatory elements." @default.
- W2895860273 created "2018-10-26" @default.
- W2895860273 creator A5021868897 @default.
- W2895860273 creator A5027470085 @default.
- W2895860273 creator A5064008475 @default.
- W2895860273 creator A5068080675 @default.
- W2895860273 creator A5073430888 @default.
- W2895860273 creator A5078367199 @default.
- W2895860273 creator A5082856046 @default.
- W2895860273 creator A5089860689 @default.
- W2895860273 date "2018-12-01" @default.
- W2895860273 modified "2023-10-16" @default.
- W2895860273 title "Virus-Induced Changes in mRNA Secondary Structure Uncover cis-Regulatory Elements that Directly Control Gene Expression" @default.
- W2895860273 cites W1528410389 @default.
- W2895860273 cites W1913136372 @default.
- W2895860273 cites W1965772972 @default.
- W2895860273 cites W1969389753 @default.
- W2895860273 cites W1970827552 @default.
- W2895860273 cites W1974454061 @default.
- W2895860273 cites W1977329434 @default.
- W2895860273 cites W1980600234 @default.
- W2895860273 cites W1985278607 @default.
- W2895860273 cites W1988075792 @default.
- W2895860273 cites W2000137108 @default.
- W2895860273 cites W2002664542 @default.
- W2895860273 cites W2003993220 @default.
- W2895860273 cites W2005105006 @default.
- W2895860273 cites W2010005720 @default.
- W2895860273 cites W2014162007 @default.
- W2895860273 cites W2014536762 @default.
- W2895860273 cites W2016322829 @default.
- W2895860273 cites W2019337061 @default.
- W2895860273 cites W2026181790 @default.
- W2895860273 cites W2031211461 @default.
- W2895860273 cites W2034199961 @default.
- W2895860273 cites W2038598202 @default.
- W2895860273 cites W2039907166 @default.
- W2895860273 cites W2046335009 @default.
- W2895860273 cites W2047405192 @default.
- W2895860273 cites W2048728930 @default.
- W2895860273 cites W2051159020 @default.
- W2895860273 cites W2055624262 @default.
- W2895860273 cites W2063310200 @default.
- W2895860273 cites W2064370916 @default.
- W2895860273 cites W2076091642 @default.
- W2895860273 cites W2083543262 @default.
- W2895860273 cites W2086561953 @default.
- W2895860273 cites W2086882580 @default.
- W2895860273 cites W2089790309 @default.
- W2895860273 cites W2092708670 @default.
- W2895860273 cites W2107704801 @default.
- W2895860273 cites W2120772351 @default.
- W2895860273 cites W2122550126 @default.
- W2895860273 cites W2124985265 @default.
- W2895860273 cites W2125654235 @default.
- W2895860273 cites W2144353739 @default.
- W2895860273 cites W2148419405 @default.
- W2895860273 cites W2151596277 @default.
- W2895860273 cites W2154031143 @default.
- W2895860273 cites W2160378127 @default.
- W2895860273 cites W2160726676 @default.
- W2895860273 cites W2167550127 @default.
- W2895860273 cites W2168138973 @default.
- W2895860273 cites W2169067144 @default.
- W2895860273 cites W2170513170 @default.
- W2895860273 cites W2174645876 @default.
- W2895860273 cites W2212720078 @default.
- W2895860273 cites W2307041907 @default.
- W2895860273 cites W2554920439 @default.
- W2895860273 cites W2770844838 @default.
- W2895860273 cites W2793097545 @default.
- W2895860273 cites W2801904155 @default.
- W2895860273 cites W52783179 @default.
- W2895860273 doi "https://doi.org/10.1016/j.molcel.2018.09.003" @default.
- W2895860273 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30318442" @default.
- W2895860273 hasPublicationYear "2018" @default.
- W2895860273 type Work @default.
- W2895860273 sameAs 2895860273 @default.
- W2895860273 citedByCount "37" @default.
- W2895860273 countsByYear W28958602732019 @default.
- W2895860273 countsByYear W28958602732020 @default.
- W2895860273 countsByYear W28958602732021 @default.
- W2895860273 countsByYear W28958602732022 @default.
- W2895860273 countsByYear W28958602732023 @default.
- W2895860273 crossrefType "journal-article" @default.
- W2895860273 hasAuthorship W2895860273A5021868897 @default.
- W2895860273 hasAuthorship W2895860273A5027470085 @default.
- W2895860273 hasAuthorship W2895860273A5064008475 @default.
- W2895860273 hasAuthorship W2895860273A5068080675 @default.
- W2895860273 hasAuthorship W2895860273A5073430888 @default.
- W2895860273 hasAuthorship W2895860273A5078367199 @default.
- W2895860273 hasAuthorship W2895860273A5082856046 @default.
- W2895860273 hasAuthorship W2895860273A5089860689 @default.
- W2895860273 hasBestOaLocation W28958602731 @default.
- W2895860273 hasConcept C104317684 @default.
- W2895860273 hasConcept C105580179 @default.
- W2895860273 hasConcept C149364088 @default.
- W2895860273 hasConcept C150194340 @default.