FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895860390> ?p ?o ?g. }

• W2895860390 endingPage "1270" @default.
• W2895860390 startingPage "1258" @default.
• W2895860390 abstract "(-)-Hydroxycitric acid [(-)-HCA] is widely used as a nutritional supplement to control body weight and fat accumulation in animals and humans, whereas the underlying biochemical mechanism is unclear. Broiler chicken was used as a model for studies of obesity due to its natural hyperglycemia and being insulin resistant. The current study aimed to obtain a systematic view of serum metabolites and hepatic proteins and well understand the mechanism of hepatic metabolic response to (-)-HCA treatment in chick embryos. The results showed that 22, 90, and 82 of differentially expressed proteins were identified at E14d, E19d, and H1d in chick embryos treated with (-)-HCA, respectively. Meanwhile, 5, 83, and 88 of serum metabolites significantly changed at E14d, E19d, and H1d in chick embryos after (-)-HCA treatment. Bioinformatics analysis showed that the key proteins and metabolites, which were significantly altered in chick embryos treated with (-)-HCA, were mainly involved in the citrate cycle, glycolysis/gluconeogenesis, fatty acid metabolism, and pyruvate metabolism. Our data indicated that (-)-HCA treatment might promote fat metabolism via regulating the key protein expression levels and metabolite contents in the citrate cycle, glycolysis/gluconeogenesis, and oxidative phosphorylation during chicken embryonic development. These results will deepen our understanding of the mechanism of fat reduction by (-)-HCA and provide substantial information for (-)-HCA as a nutritional supplement to control body weight gain and curb obesity-related diseases." @default.
• W2895860390 created "2018-10-26" @default.
• W2895860390 creator A5026231812 @default.
• W2895860390 creator A5040579986 @default.
• W2895860390 creator A5075612231 @default.
• W2895860390 creator A5091199678 @default.
• W2895860390 creator A5035584219 @default.
• W2895860390 date "2018-10-14" @default.
• W2895860390 modified "2023-09-28" @default.
• W2895860390 title "Integrated analysis of proteomics‐delineated and metabolomics‐delineated hepatic metabolic responses to (−)‐hydroxycitric acid in chick embryos" @default.
• W2895860390 cites W1511590410 @default.
• W2895860390 cites W1604245576 @default.
• W2895860390 cites W1969082909 @default.
• W2895860390 cites W1973203822 @default.
• W2895860390 cites W1976784452 @default.
• W2895860390 cites W1978058114 @default.
• W2895860390 cites W1985712742 @default.
• W2895860390 cites W1987406457 @default.
• W2895860390 cites W1989311738 @default.
• W2895860390 cites W1992483596 @default.
• W2895860390 cites W1994579482 @default.
• W2895860390 cites W1994824929 @default.
• W2895860390 cites W1995057972 @default.
• W2895860390 cites W2008830840 @default.
• W2895860390 cites W2019019085 @default.
• W2895860390 cites W2023535481 @default.
• W2895860390 cites W2030878833 @default.
• W2895860390 cites W2031769705 @default.
• W2895860390 cites W2034801970 @default.
• W2895860390 cites W2038639306 @default.
• W2895860390 cites W2047224959 @default.
• W2895860390 cites W2048935510 @default.
• W2895860390 cites W2054248098 @default.
• W2895860390 cites W2059794578 @default.
• W2895860390 cites W2067333453 @default.
• W2895860390 cites W2067942093 @default.
• W2895860390 cites W2071206113 @default.
• W2895860390 cites W2074500345 @default.
• W2895860390 cites W2092003178 @default.
• W2895860390 cites W2098459972 @default.
• W2895860390 cites W2110553209 @default.
• W2895860390 cites W2140038597 @default.
• W2895860390 cites W2153721752 @default.
• W2895860390 cites W2172134232 @default.
• W2895860390 cites W2276160927 @default.
• W2895860390 cites W2523359405 @default.
• W2895860390 cites W2543820858 @default.
• W2895860390 cites W2549028209 @default.
• W2895860390 cites W2561079026 @default.
• W2895860390 cites W4293247451 @default.
• W2895860390 doi "https://doi.org/10.1002/jcb.27085" @default.
• W2895860390 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30317645" @default.
• W2895860390 hasPublicationYear "2018" @default.
• W2895860390 type Work @default.
• W2895860390 sameAs 2895860390 @default.
• W2895860390 citedByCount "6" @default.
• W2895860390 countsByYear W28958603902019 @default.
• W2895860390 countsByYear W28958603902020 @default.
• W2895860390 countsByYear W28958603902021 @default.
• W2895860390 countsByYear W28958603902022 @default.
• W2895860390 crossrefType "journal-article" @default.
• W2895860390 hasAuthorship W2895860390A5026231812 @default.
• W2895860390 hasAuthorship W2895860390A5035584219 @default.
• W2895860390 hasAuthorship W2895860390A5040579986 @default.
• W2895860390 hasAuthorship W2895860390A5075612231 @default.
• W2895860390 hasAuthorship W2895860390A5091199678 @default.
• W2895860390 hasConcept C126322002 @default.
• W2895860390 hasConcept C134018914 @default.
• W2895860390 hasConcept C165135838 @default.
• W2895860390 hasConcept C17093226 @default.
• W2895860390 hasConcept C196843134 @default.
• W2895860390 hasConcept C20251656 @default.
• W2895860390 hasConcept C20904676 @default.
• W2895860390 hasConcept C21565614 @default.
• W2895860390 hasConcept C2776991927 @default.
• W2895860390 hasConcept C2777477808 @default.
• W2895860390 hasConcept C543025807 @default.
• W2895860390 hasConcept C55493867 @default.
• W2895860390 hasConcept C57600042 @default.
• W2895860390 hasConcept C60644358 @default.
• W2895860390 hasConcept C62231903 @default.
• W2895860390 hasConcept C71924100 @default.
• W2895860390 hasConcept C82714985 @default.
• W2895860390 hasConcept C86803240 @default.
• W2895860390 hasConcept C95444343 @default.
• W2895860390 hasConceptScore W2895860390C126322002 @default.
• W2895860390 hasConceptScore W2895860390C134018914 @default.
• W2895860390 hasConceptScore W2895860390C165135838 @default.
• W2895860390 hasConceptScore W2895860390C17093226 @default.
• W2895860390 hasConceptScore W2895860390C196843134 @default.
• W2895860390 hasConceptScore W2895860390C20251656 @default.
• W2895860390 hasConceptScore W2895860390C20904676 @default.
• W2895860390 hasConceptScore W2895860390C21565614 @default.
• W2895860390 hasConceptScore W2895860390C2776991927 @default.
• W2895860390 hasConceptScore W2895860390C2777477808 @default.
• W2895860390 hasConceptScore W2895860390C543025807 @default.
• W2895860390 hasConceptScore W2895860390C55493867 @default.
• W2895860390 hasConceptScore W2895860390C57600042 @default.

• next