FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895868478> ?p ?o ?g. }

• W2895868478 endingPage "190" @default.
• W2895868478 startingPage "185" @default.
• W2895868478 abstract "Vitamin C exhibits interesting properties in the context of critical illness, with benefits described in neurologic, cardiovascular, renal, and hematologic systems, both in in vitro and in animal models. Through direct effects on bacterial replication, immunomodulation, and antioxidant reserve of the organism, vitamin C directly affects the pathophysiological process of sepsis, trauma, burn, and systemic inflammation. Even if several observational trials have linked vitamin C deficiency to worse outcomes, the evidence is not such as to provide us with a distinction between causality effects or simple epiphenomenon, and the current focus is on interventional trials. Pharmacokinetic data suggest that a minimal supplementation of 3 g/d intravenously is required to restore normal serum values in critically ill patients with known deficiency. According to these data, only five trials, including a retrospective analysis, studied pharmacologic dose: three as an antioxidant cocktail and two as monotherapy. The largest trial, conducted in 2002, reported reduced incidence of multiorgan failure and duration of mechanical ventilation. Recently a retrospective analysis reported impressive results after administration of vitamin C, thiamine, and hydrocortisone. The two most recent trials reported improved clinical outcomes, including improved mortality, but contained significant methodological limitations. A recent systematic review did not find clinical benefits with the most-studied low-dose oral supplementation, potentially because of suboptimal or insufficient repletion. Current guidelines do not support the administration of high-dose vitamin C in critically ill patients. Future larger trials are required to support any therapy, but the low cost and safety profile can justify supplementation in the meantime. Metabolomics study will further help understand biological effect." @default.
• W2895868478 created "2018-10-26" @default.
• W2895868478 creator A5037956429 @default.
• W2895868478 creator A5052068366 @default.
• W2895868478 date "2019-04-01" @default.
• W2895868478 modified "2023-10-01" @default.
• W2895868478 title "Vitamin C for the critically ill: Is the evidence strong enough?" @default.
• W2895868478 cites W1966488439 @default.
• W2895868478 cites W1969375160 @default.
• W2895868478 cites W1982169353 @default.
• W2895868478 cites W1986327778 @default.
• W2895868478 cites W2006012714 @default.
• W2895868478 cites W2007142246 @default.
• W2895868478 cites W2014068888 @default.
• W2895868478 cites W2029032281 @default.
• W2895868478 cites W2042537629 @default.
• W2895868478 cites W2043649744 @default.
• W2895868478 cites W2044959285 @default.
• W2895868478 cites W2049662677 @default.
• W2895868478 cites W2050164421 @default.
• W2895868478 cites W2050515690 @default.
• W2895868478 cites W2052658348 @default.
• W2895868478 cites W2053015922 @default.
• W2895868478 cites W2063749178 @default.
• W2895868478 cites W2075521402 @default.
• W2895868478 cites W2086301846 @default.
• W2895868478 cites W2089090834 @default.
• W2895868478 cites W2090488818 @default.
• W2895868478 cites W2093405765 @default.
• W2895868478 cites W2095720502 @default.
• W2895868478 cites W2109214836 @default.
• W2895868478 cites W2110097866 @default.
• W2895868478 cites W2121313585 @default.
• W2895868478 cites W2133109255 @default.
• W2895868478 cites W2142538185 @default.
• W2895868478 cites W2147220913 @default.
• W2895868478 cites W2152465977 @default.
• W2895868478 cites W2170160758 @default.
• W2895868478 cites W2170737858 @default.
• W2895868478 cites W2314267398 @default.
• W2895868478 cites W2318294335 @default.
• W2895868478 cites W2323937345 @default.
• W2895868478 cites W2333388184 @default.
• W2895868478 cites W2400978818 @default.
• W2895868478 cites W2560240742 @default.
• W2895868478 cites W2584760661 @default.
• W2895868478 cites W2766820812 @default.
• W2895868478 cites W2773432284 @default.
• W2895868478 cites W2775256121 @default.
• W2895868478 cites W2793944051 @default.
• W2895868478 cites W2795160781 @default.
• W2895868478 cites W4248746144 @default.
• W2895868478 doi "https://doi.org/10.1016/j.nut.2018.10.009" @default.
• W2895868478 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30612038" @default.
• W2895868478 hasPublicationYear "2019" @default.
• W2895868478 type Work @default.
• W2895868478 sameAs 2895868478 @default.
• W2895868478 citedByCount "21" @default.
• W2895868478 countsByYear W28958684782020 @default.
• W2895868478 countsByYear W28958684782021 @default.
• W2895868478 countsByYear W28958684782022 @default.
• W2895868478 countsByYear W28958684782023 @default.
• W2895868478 crossrefType "journal-article" @default.
• W2895868478 hasAuthorship W2895868478A5037956429 @default.
• W2895868478 hasAuthorship W2895868478A5052068366 @default.
• W2895868478 hasConcept C126322002 @default.
• W2895868478 hasConcept C151730666 @default.
• W2895868478 hasConcept C177713679 @default.
• W2895868478 hasConcept C2778384902 @default.
• W2895868478 hasConcept C2779343474 @default.
• W2895868478 hasConcept C535046627 @default.
• W2895868478 hasConcept C71924100 @default.
• W2895868478 hasConcept C86803240 @default.
• W2895868478 hasConceptScore W2895868478C126322002 @default.
• W2895868478 hasConceptScore W2895868478C151730666 @default.
• W2895868478 hasConceptScore W2895868478C177713679 @default.
• W2895868478 hasConceptScore W2895868478C2778384902 @default.
• W2895868478 hasConceptScore W2895868478C2779343474 @default.
• W2895868478 hasConceptScore W2895868478C535046627 @default.
• W2895868478 hasConceptScore W2895868478C71924100 @default.
• W2895868478 hasConceptScore W2895868478C86803240 @default.
• W2895868478 hasLocation W28958684781 @default.
• W2895868478 hasLocation W28958684782 @default.
• W2895868478 hasOpenAccess W2895868478 @default.
• W2895868478 hasPrimaryLocation W28958684781 @default.
• W2895868478 hasRelatedWork W1494648848 @default.
• W2895868478 hasRelatedWork W1971537896 @default.
• W2895868478 hasRelatedWork W2008247344 @default.
• W2895868478 hasRelatedWork W2047899975 @default.
• W2895868478 hasRelatedWork W2053246203 @default.
• W2895868478 hasRelatedWork W2408010109 @default.
• W2895868478 hasRelatedWork W2412142349 @default.
• W2895868478 hasRelatedWork W2547092455 @default.
• W2895868478 hasRelatedWork W4243642339 @default.
• W2895868478 hasRelatedWork W4386050759 @default.
• W2895868478 hasVolume "60" @default.
• W2895868478 isParatext "false" @default.
• W2895868478 isRetracted "false" @default.

• next