FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895869176> ?p ?o ?g. }

• W2895869176 endingPage "194" @default.
• W2895869176 startingPage "194" @default.
• W2895869176 abstract "The effect of solvent removal techniques on phase transition, physical stability and dissolution of bicalutamide from solid dispersions containing polyvinylpyrrolidone (PVP) as a carrier was investigated. A spray dryer and a rotavapor were applied to obtain binary systems containing either 50% or 66% of the drug. Applied techniques led to the formation of amorphous solid dispersions as confirmed by X-ray powder diffractometry and differential scanning calorimetry. Moreover, solid–solid transition from polymorphic form I to form II was observed for bicalutamide spray dried without a carrier. The presence of intermolecular interactions between the drug and polymer molecules, which provides the stabilization of molecularly disordered bicalutamide, was analyzed using infrared spectroscopy. Spectral changes within the region characteristic for amide vibrations suggested that the amide form of crystalline bicalutamide was replaced by a less stable imidic one, characteristic of an amorphous drug. Applied processes also resulted in changes of particle geometry and size as confirmed by scanning electron microscopy and laser diffraction measurements, however they did not affect the dissolution significantly as confirmed by intrinsic dissolution study. The enhancement of apparent solubility and dissolution were assigned mostly to the loss of molecular arrangement by drug molecules. Performed statistical analysis indicated that the presence of PVP reduces the mean dissolution time and improve the dissolution efficiency. Although the dissolution was equally affected by both applied methods of solid dispersion manufacturing, spray drying provides better control of particle size and morphology as well as a lower tendency for recrystallization of amorphous solid dispersions." @default.
• W2895869176 created "2018-10-26" @default.
• W2895869176 creator A5007578528 @default.
• W2895869176 creator A5015791716 @default.
• W2895869176 creator A5023726468 @default.
• W2895869176 creator A5036565576 @default.
• W2895869176 creator A5039791408 @default.
• W2895869176 creator A5053657588 @default.
• W2895869176 creator A5067783003 @default.
• W2895869176 creator A5071374971 @default.
• W2895869176 creator A5075251694 @default.
• W2895869176 date "2018-10-18" @default.
• W2895869176 modified "2023-10-18" @default.
• W2895869176 title "Molecular Disorder of Bicalutamide—Amorphous Solid Dispersions Obtained by Solvent Methods" @default.
• W2895869176 cites W1060565426 @default.
• W2895869176 cites W1076140267 @default.
• W2895869176 cites W1589854335 @default.
• W2895869176 cites W1805013482 @default.
• W2895869176 cites W1984760065 @default.
• W2895869176 cites W2014879978 @default.
• W2895869176 cites W2015789233 @default.
• W2895869176 cites W2024610484 @default.
• W2895869176 cites W2033018925 @default.
• W2895869176 cites W2042599300 @default.
• W2895869176 cites W2045270881 @default.
• W2895869176 cites W2047948690 @default.
• W2895869176 cites W2059669519 @default.
• W2895869176 cites W2061991269 @default.
• W2895869176 cites W206315215 @default.
• W2895869176 cites W2079039801 @default.
• W2895869176 cites W2094506063 @default.
• W2895869176 cites W2112054646 @default.
• W2895869176 cites W2120654923 @default.
• W2895869176 cites W2133061394 @default.
• W2895869176 cites W2134665153 @default.
• W2895869176 cites W2183570525 @default.
• W2895869176 cites W2190949340 @default.
• W2895869176 cites W2202134586 @default.
• W2895869176 cites W2233376589 @default.
• W2895869176 cites W2253675932 @default.
• W2895869176 cites W2275944058 @default.
• W2895869176 cites W2277540371 @default.
• W2895869176 cites W2332288570 @default.
• W2895869176 cites W2423995248 @default.
• W2895869176 cites W2589981309 @default.
• W2895869176 cites W2603453641 @default.
• W2895869176 cites W2724351943 @default.
• W2895869176 cites W2156076036 @default.
• W2895869176 doi "https://doi.org/10.3390/pharmaceutics10040194" @default.
• W2895869176 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6321060" @default.
• W2895869176 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30340413" @default.
• W2895869176 hasPublicationYear "2018" @default.
• W2895869176 type Work @default.
• W2895869176 sameAs 2895869176 @default.
• W2895869176 citedByCount "14" @default.
• W2895869176 countsByYear W28958691762019 @default.
• W2895869176 countsByYear W28958691762020 @default.
• W2895869176 countsByYear W28958691762021 @default.
• W2895869176 countsByYear W28958691762022 @default.
• W2895869176 countsByYear W28958691762023 @default.
• W2895869176 crossrefType "journal-article" @default.
• W2895869176 hasAuthorship W2895869176A5007578528 @default.
• W2895869176 hasAuthorship W2895869176A5015791716 @default.
• W2895869176 hasAuthorship W2895869176A5023726468 @default.
• W2895869176 hasAuthorship W2895869176A5036565576 @default.
• W2895869176 hasAuthorship W2895869176A5039791408 @default.
• W2895869176 hasAuthorship W2895869176A5053657588 @default.
• W2895869176 hasAuthorship W2895869176A5067783003 @default.
• W2895869176 hasAuthorship W2895869176A5071374971 @default.
• W2895869176 hasAuthorship W2895869176A5075251694 @default.
• W2895869176 hasBestOaLocation W28958691761 @default.
• W2895869176 hasConcept C121332964 @default.
• W2895869176 hasConcept C127413603 @default.
• W2895869176 hasConcept C147789679 @default.
• W2895869176 hasConcept C155574463 @default.
• W2895869176 hasConcept C178790620 @default.
• W2895869176 hasConcept C185592680 @default.
• W2895869176 hasConcept C187530423 @default.
• W2895869176 hasConcept C188027245 @default.
• W2895869176 hasConcept C192562407 @default.
• W2895869176 hasConcept C203036418 @default.
• W2895869176 hasConcept C2780077769 @default.
• W2895869176 hasConcept C39519442 @default.
• W2895869176 hasConcept C42360764 @default.
• W2895869176 hasConcept C56052488 @default.
• W2895869176 hasConcept C88380143 @default.
• W2895869176 hasConcept C97355855 @default.
• W2895869176 hasConceptScore W2895869176C121332964 @default.
• W2895869176 hasConceptScore W2895869176C127413603 @default.
• W2895869176 hasConceptScore W2895869176C147789679 @default.
• W2895869176 hasConceptScore W2895869176C155574463 @default.
• W2895869176 hasConceptScore W2895869176C178790620 @default.
• W2895869176 hasConceptScore W2895869176C185592680 @default.
• W2895869176 hasConceptScore W2895869176C187530423 @default.
• W2895869176 hasConceptScore W2895869176C188027245 @default.
• W2895869176 hasConceptScore W2895869176C192562407 @default.
• W2895869176 hasConceptScore W2895869176C203036418 @default.
• W2895869176 hasConceptScore W2895869176C2780077769 @default.

• next