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- W2895869463 abstract "Eukaryotes are divided into two major compartments: the nucleus where RNA is synthesized and processed, and the cytoplasm, where mRNA is translated into proteins. Although many different RNAs are made, only a subset is allowed access to the cytoplasm, primarily RNAs involved in protein synthesis (mRNA, tRNA, and rRNA). In contrast, nuclear retained transcripts are mostly long non-coding RNAs (lncRNAs) whose role in cell physiology has been a source of much investigation in the past few years. In addition, it is likely that many non-functional RNAs, which arise by spurious transcription and misprocessing of functional RNAs, are also retained in the nucleus and degraded. In this review, the main sequence features that dictate whether any particular mRNA or lncRNA is a substrate for retention in the nucleus, or export to the cytoplasm, are discussed. Although nuclear export is promoted by RNA-splicing due to the fact that the spliceosome can help recruit export factors to the mature RNA, nuclear export does not require splicing. Indeed, most stable unspliced transcripts are well exported and associate with these same export factors in a splicing-independent manner. In contrast, nuclear retention is promoted by specialized cis-elements found in certain RNAs. This new understanding of the determinants of nuclear retention and cytoplasmic export provides a deeper understanding of how information flow is regulated in eukaryotic cells. Ultimately these processes promote the evolution of complexity in eukaryotes by shaping the genomic content through constructive neutral evolution." @default.
- W2895869463 created "2018-10-26" @default.
- W2895869463 creator A5013107243 @default.
- W2895869463 creator A5069097393 @default.
- W2895869463 date "2018-10-17" @default.
- W2895869463 modified "2023-10-13" @default.
- W2895869463 title "Sequence Determinants for Nuclear Retention and Cytoplasmic Export of mRNAs and lncRNAs" @default.
- W2895869463 cites W1500914927 @default.
- W2895869463 cites W1561508140 @default.
- W2895869463 cites W1586091421 @default.
- W2895869463 cites W1771985274 @default.
- W2895869463 cites W1844304435 @default.
- W2895869463 cites W1925157233 @default.
- W2895869463 cites W1951632364 @default.
- W2895869463 cites W1966132457 @default.
- W2895869463 cites W1966735041 @default.
- W2895869463 cites W1967610907 @default.
- W2895869463 cites W1967959947 @default.
- W2895869463 cites W1970995078 @default.
- W2895869463 cites W1974113894 @default.
- W2895869463 cites W1974177610 @default.
- W2895869463 cites W1974292824 @default.
- W2895869463 cites W1974434328 @default.
- W2895869463 cites W1976066719 @default.
- W2895869463 cites W1977343831 @default.
- W2895869463 cites W1980259025 @default.
- W2895869463 cites W1981176106 @default.
- W2895869463 cites W1984594593 @default.
- W2895869463 cites W1984758353 @default.
- W2895869463 cites W1990478192 @default.
- W2895869463 cites W1991641998 @default.
- W2895869463 cites W1993287040 @default.
- W2895869463 cites W1995842607 @default.
- W2895869463 cites W1997054318 @default.
- W2895869463 cites W1997493439 @default.
- W2895869463 cites W1999721918 @default.
- W2895869463 cites W2002881421 @default.
- W2895869463 cites W2003462362 @default.
- W2895869463 cites W2006931677 @default.
- W2895869463 cites W2007165715 @default.
- W2895869463 cites W2008677817 @default.
- W2895869463 cites W2009183437 @default.
- W2895869463 cites W2015775176 @default.
- W2895869463 cites W2016625616 @default.
- W2895869463 cites W2019860831 @default.
- W2895869463 cites W2020928530 @default.
- W2895869463 cites W2021678907 @default.
- W2895869463 cites W2022546135 @default.
- W2895869463 cites W2027159300 @default.
- W2895869463 cites W2027314078 @default.
- W2895869463 cites W2029291109 @default.
- W2895869463 cites W2030136842 @default.
- W2895869463 cites W2030658020 @default.
- W2895869463 cites W2030677655 @default.
- W2895869463 cites W2031985285 @default.
- W2895869463 cites W2033171415 @default.
- W2895869463 cites W2035268935 @default.
- W2895869463 cites W2037495678 @default.
- W2895869463 cites W2037534409 @default.
- W2895869463 cites W2038138598 @default.
- W2895869463 cites W2041676007 @default.
- W2895869463 cites W2042973755 @default.
- W2895869463 cites W2045845081 @default.
- W2895869463 cites W2049314528 @default.
- W2895869463 cites W2051887414 @default.
- W2895869463 cites W2054560514 @default.
- W2895869463 cites W2056755041 @default.
- W2895869463 cites W2056967728 @default.
- W2895869463 cites W2060782543 @default.
- W2895869463 cites W2060902122 @default.
- W2895869463 cites W2062714021 @default.
- W2895869463 cites W2065466457 @default.
- W2895869463 cites W2065847836 @default.
- W2895869463 cites W2069084578 @default.
- W2895869463 cites W2069490539 @default.
- W2895869463 cites W2070498223 @default.
- W2895869463 cites W2076054312 @default.
- W2895869463 cites W2076304484 @default.
- W2895869463 cites W2077808289 @default.
- W2895869463 cites W2078906823 @default.
- W2895869463 cites W2078964320 @default.
- W2895869463 cites W2080889642 @default.
- W2895869463 cites W2081873181 @default.
- W2895869463 cites W2081985491 @default.
- W2895869463 cites W2085928743 @default.
- W2895869463 cites W2090227993 @default.
- W2895869463 cites W2091777602 @default.
- W2895869463 cites W2092594273 @default.
- W2895869463 cites W2092850798 @default.
- W2895869463 cites W2093827499 @default.
- W2895869463 cites W2096237610 @default.
- W2895869463 cites W2096767063 @default.
- W2895869463 cites W2098422223 @default.
- W2895869463 cites W2099294083 @default.
- W2895869463 cites W2099905512 @default.
- W2895869463 cites W2100361299 @default.
- W2895869463 cites W2100377469 @default.
- W2895869463 cites W2101543197 @default.
- W2895869463 cites W2103744237 @default.
- W2895869463 cites W2104063911 @default.