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• W2895869808 abstract "A new peroxy fatty acid, tagetnoic acid (5) [4-((3S,6S)-6-((3E,8E)-octadeca-3,8-dien-1-yl)-3,6-dihydro-1,2-dioxin-3-yl)butanoic acid] and four known metabolites: ecliptal (5-formyl-α-terthiophene) (1), 5-(4-hydroxybut-1-ynyl)-2,2′-bithiophene (2), 22,23-dihydrospinasterone (3), and stigmasterol (4) were separated from the n-hexane fraction of the aerial parts of Tagetes minuta L. (Asteraceae). Their chemical structures were verified using IR, UV, 2D and 1D NMR, and HRMS. Compounds 3–5 displayed potent lipoxygenase inhibitory potential with IC50s 2.26, 1.83, and 1.17 μM, respectively compared to indomethacin (IC50 0.89 μM). Moreover, molecular docking study revealed that the potent activity of 5 is due to H-bonding and hydrophobic interaction. The results of this study suggested that Tagetes minuta dietary consumption would be useful for the individuals at risk of acute and chronic inflammatory disorders." @default.
• W2895869808 created "2018-10-26" @default.
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• W2895869808 date "2018-10-08" @default.
• W2895869808 modified "2023-10-16" @default.
• W2895869808 title "Tagetnoic acid, a new lipoxygenase inhibitor peroxy fatty acid from<i>Tagetes minuta</i>growing in Saudi Arabia" @default.
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• W2895869808 doi "https://doi.org/10.1080/14786419.2018.1488712" @default.
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