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• W2895872312 abstract "Abstract Background It is usually considered that the upper airway epithelium is composed of multiciliated, goblet, secretory and basal cells, which collectively constitute an efficient first line of defense against inhalation of noxious substances. Upon injury, regeneration of this epithelium through proliferation and differentiation can restore a proper mucociliary function. However, in chronic airway diseases, the injured epithelium frequently displays defective repair leading to tissue remodeling, characterized by a loss of multiciliated cells and mucus hyper-secretion. Delineating drivers of differentiation dynamics and cell fate in the human airway epithelium is important to preserve homeostasis. Results We have used single cell transcriptomics to characterize the sequence of cellular and molecular processes taking place during human airway epithelium regeneration. We have characterized airway subpopulations with high resolution and lineage inference algorithms have unraveled cell trajectories from basal to luminal cells, providing markers for specific cell populations, such as deuterosomal cells, i.e. precursors of multiciliated cells. We report that goblet cells, like secretory cells, can act as precursors of multiciliated cells. Our study provides a repertoire of molecules involved in key steps of the regeneration process, either keratins or components of the Notch, Wnt or BMP/TGFβ signaling pathways. Our findings were confirmed in independent experiments performed on fresh human and pig airway samples, and on mouse tracheal epithelial cells. Conclusions Our single-cell RNA-seq study provides novel insights about airway epithelium differentiation dynamics, clarifies cell trajectories between secretory, goblet and multiciliated cells, identifies novel cell subpopulations, and maps the activation and repression of key signaling pathways." @default.
• W2895872312 created "2018-10-26" @default.
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• W2895872312 date "2018-10-24" @default.
• W2895872312 modified "2023-10-16" @default.
• W2895872312 title "Single-cell RNA sequencing reveals novel cell differentiation dynamics during human airway epithelium regeneration" @default.
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• W2895872312 cites W1773938361 @default.
• W2895872312 cites W1833806604 @default.
• W2895872312 cites W1945952516 @default.
• W2895872312 cites W1967278344 @default.
• W2895872312 cites W1968203528 @default.
• W2895872312 cites W1984514451 @default.
• W2895872312 cites W1994123173 @default.
• W2895872312 cites W2004054793 @default.
• W2895872312 cites W2007610579 @default.
• W2895872312 cites W2011811265 @default.
• W2895872312 cites W2012319310 @default.
• W2895872312 cites W2013657285 @default.
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• W2895872312 cites W2035639023 @default.
• W2895872312 cites W2057813347 @default.
• W2895872312 cites W2068881679 @default.
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• W2895872312 cites W2127463575 @default.
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• W2895872312 doi "https://doi.org/10.1101/451807" @default.
• W2895872312 hasPublicationYear "2018" @default.
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