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• W2895872414 abstract "Abstract Introduction Appraising quality of evidence (QoE) is an essential process for performing systematic reviews. The Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) is one of the tools for assessing QoE, however, concerns about its reliability and comprehensiveness have been raised. To address these shortcomings, we developed the Clinical and Health Intervention Meta-analysis Evidence RAting System (CHIMERAS). Methods A single-center, parallel randomized controlled trial was conducted to assess and compare the reliability of CHIMERAS and GRADE. Raters were randomly assigned into two groups. They were trained to use either GRADE or CHIMERAS for assessing QoE. QoE from 100 Cochrane systematic reviews (SRs) was assessed with GRADE in group 1 and CHIMERAS in group 2. Inter-rater reliability and inter-consensus reliability were evaluated by calculating the intra-class correlation (ICC). Results CHIMERAS showed moderate agreement (ICC = 0.54, 95% confidence interval [CI]: 0.44-0.64), while GRADE had fair agreement (ICC = 0.38, 95% CI: 0.28-0.49) for inter-rater reliability among individual raters. CHIMERAS showed substantial agreement (ICC = 0.78, 95% CI: 0.69-0.84), while GRADE had moderate agreement (ICC = 0.52, 95% CI: 0.36-0.65) for inter-consensus reliability across pairs of raters. With GRADE, respectively 77.0% and 11.0% SRs were judged as having low or very low, and high QoE. With CHIMERAS, respectively 10.0% and 54.0% SRs were judged as having low or very low, and high or very high QoE. Conclusion CHIMERAS outperformed GRADE in terms of inter-rater reliability and inter-consensus reliability. CHIMERAS and GRADE also showed substantial disagreement in grading QoE, indicating the possible impact on decision making attributable to varying rating approaches. Trial registration Protocol of this trial has been registered prospectively in the Chinese Clinical Trial Registry (Registration number: ChiCTR-IOR-16008898) on 13 July 2016." @default.
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• W2895872414 date "2018-10-01" @default.
• W2895872414 modified "2023-09-26" @default.
• W2895872414 title "CHIMERAS showed better inter-rater reliability and inter-consensus reliability than GRADE in grading quality of evidence: A randomized controlled trial" @default.
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• W2895872414 doi "https://doi.org/10.1016/j.eujim.2018.10.008" @default.
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