Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895874961> ?p ?o ?g. }
- W2895874961 endingPage "9690" @default.
- W2895874961 startingPage "9666" @default.
- W2895874961 abstract "In order to detect novel σ receptor ligands, the rigid spiro[[2]benzopyran-1,1′-cyclohexan]-4′-one was connected with amino moieties derived from σ2 receptor preferring lead compounds resulting in mixtures of trans- and cis-configured amines 6, 18, and 27. In a four step synthesis the methyl acetals 6 were converted into fluoroethyl derivatives 13 and 30. The most promising σ2 receptor ligand is the methyl acetal 6a bearing a 2,4-dimethylbenzylamino moiety. The fluoroethyl derivatives 13c and 13d reveal high σ1 affinity but moderate selectivity over the σ2 subtype. In mice 13c and 13d showed antiallodynic activity that is stronger than that of the reference σ1 antagonist BD-1063 (34). Since the antiallodynic activity of 13c could only be partially reversed by the σ1 agonist PRE-084 (35), it is postulated that a second mechanism contributes to its overall antiallodynic effect. In contrast, the antiallodynic effect of its diastereomer 13d can be totally explained by a σ1 antagonism." @default.
- W2895874961 created "2018-10-26" @default.
- W2895874961 creator A5015542216 @default.
- W2895874961 creator A5015679062 @default.
- W2895874961 creator A5018790724 @default.
- W2895874961 creator A5026578227 @default.
- W2895874961 creator A5028688499 @default.
- W2895874961 creator A5034751002 @default.
- W2895874961 creator A5040260186 @default.
- W2895874961 creator A5048909745 @default.
- W2895874961 creator A5066676990 @default.
- W2895874961 creator A5073720321 @default.
- W2895874961 creator A5089641507 @default.
- W2895874961 date "2018-10-12" @default.
- W2895874961 modified "2023-09-30" @default.
- W2895874961 title "Synthesis, Receptor Affinity, and Antiallodynic Activity of Spirocyclic σ Receptor Ligands with Exocyclic Amino Moiety" @default.
- W2895874961 cites W1523583251 @default.
- W2895874961 cites W1963565483 @default.
- W2895874961 cites W1965091528 @default.
- W2895874961 cites W1969752694 @default.
- W2895874961 cites W1983005267 @default.
- W2895874961 cites W1983823375 @default.
- W2895874961 cites W1988985649 @default.
- W2895874961 cites W1992517587 @default.
- W2895874961 cites W1992763610 @default.
- W2895874961 cites W1992768650 @default.
- W2895874961 cites W1994224293 @default.
- W2895874961 cites W1997062503 @default.
- W2895874961 cites W1997406080 @default.
- W2895874961 cites W1999365233 @default.
- W2895874961 cites W2001369831 @default.
- W2895874961 cites W2010919671 @default.
- W2895874961 cites W2010963787 @default.
- W2895874961 cites W2019079031 @default.
- W2895874961 cites W2026692772 @default.
- W2895874961 cites W2027930394 @default.
- W2895874961 cites W2033854365 @default.
- W2895874961 cites W2035635611 @default.
- W2895874961 cites W2042609185 @default.
- W2895874961 cites W2042804749 @default.
- W2895874961 cites W2045311068 @default.
- W2895874961 cites W2047511397 @default.
- W2895874961 cites W2048263472 @default.
- W2895874961 cites W2050750242 @default.
- W2895874961 cites W2053392800 @default.
- W2895874961 cites W2054597500 @default.
- W2895874961 cites W2056581302 @default.
- W2895874961 cites W2060885983 @default.
- W2895874961 cites W2062502420 @default.
- W2895874961 cites W2067966291 @default.
- W2895874961 cites W2071816115 @default.
- W2895874961 cites W2074631079 @default.
- W2895874961 cites W2075285753 @default.
- W2895874961 cites W2080612234 @default.
- W2895874961 cites W2103001937 @default.
- W2895874961 cites W2111631879 @default.
- W2895874961 cites W2114403556 @default.
- W2895874961 cites W2123950263 @default.
- W2895874961 cites W2125368083 @default.
- W2895874961 cites W2132454074 @default.
- W2895874961 cites W2137908724 @default.
- W2895874961 cites W2148418924 @default.
- W2895874961 cites W2157764621 @default.
- W2895874961 cites W2180006731 @default.
- W2895874961 cites W2239384431 @default.
- W2895874961 cites W2314811232 @default.
- W2895874961 cites W2335147441 @default.
- W2895874961 cites W2618221287 @default.
- W2895874961 cites W4241897573 @default.
- W2895874961 cites W4293247451 @default.
- W2895874961 cites W4323254129 @default.
- W2895874961 doi "https://doi.org/10.1021/acs.jmedchem.8b01183" @default.
- W2895874961 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30350997" @default.
- W2895874961 hasPublicationYear "2018" @default.
- W2895874961 type Work @default.
- W2895874961 sameAs 2895874961 @default.
- W2895874961 citedByCount "9" @default.
- W2895874961 countsByYear W28958749612019 @default.
- W2895874961 countsByYear W28958749612020 @default.
- W2895874961 countsByYear W28958749612021 @default.
- W2895874961 countsByYear W28958749612023 @default.
- W2895874961 crossrefType "journal-article" @default.
- W2895874961 hasAuthorship W2895874961A5015542216 @default.
- W2895874961 hasAuthorship W2895874961A5015679062 @default.
- W2895874961 hasAuthorship W2895874961A5018790724 @default.
- W2895874961 hasAuthorship W2895874961A5026578227 @default.
- W2895874961 hasAuthorship W2895874961A5028688499 @default.
- W2895874961 hasAuthorship W2895874961A5034751002 @default.
- W2895874961 hasAuthorship W2895874961A5040260186 @default.
- W2895874961 hasAuthorship W2895874961A5048909745 @default.
- W2895874961 hasAuthorship W2895874961A5066676990 @default.
- W2895874961 hasAuthorship W2895874961A5073720321 @default.
- W2895874961 hasAuthorship W2895874961A5089641507 @default.
- W2895874961 hasConcept C116569031 @default.
- W2895874961 hasConcept C138716334 @default.
- W2895874961 hasConcept C170493617 @default.
- W2895874961 hasConcept C185592680 @default.
- W2895874961 hasConcept C2776568683 @default.