FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895875699> ?p ?o ?g. }

• W2895875699 endingPage "18679" @default.
• W2895875699 startingPage "18667" @default.
• W2895875699 abstract "Phospholipids (PLs) are emerging as important factors that initiate signal transduction cascades at the plasma membrane. Their distribution within biological membranes is tightly regulated, e.g. by ATP-binding cassette (ABC) transporters, which preferably translocate PLs from the cytoplasmic to the exoplasmic membrane leaflet and are therefore called PL-floppases. Here, we demonstrate that a plant ABC transporter, Lr34 from wheat (Triticum aestivum), is involved in plasma membrane remodeling characterized by an intracellular accumulation of phosphatidic acid and enhanced outward translocation of phosphatidylserine. In addition, the content of phosphatidylinositol 4,5-bisphosphate in the cytoplasmic leaflet of the plasma membrane was reduced in the presence of the ABC transporter. When heterologously expressed in Saccharomyces cerevisiae, Lr34 promoted oil body formation in a mutant defective in PL-transfer in the secretory pathway. Our results suggest that PL redistribution by Lr34 potentially affects the membrane-bound proteome and contributes to the previously reported stimuli-independent activation of biotic and abiotic stress responses and neutral lipid accumulation in transgenic Lr34-expressing barley plants. Phospholipids (PLs) are emerging as important factors that initiate signal transduction cascades at the plasma membrane. Their distribution within biological membranes is tightly regulated, e.g. by ATP-binding cassette (ABC) transporters, which preferably translocate PLs from the cytoplasmic to the exoplasmic membrane leaflet and are therefore called PL-floppases. Here, we demonstrate that a plant ABC transporter, Lr34 from wheat (Triticum aestivum), is involved in plasma membrane remodeling characterized by an intracellular accumulation of phosphatidic acid and enhanced outward translocation of phosphatidylserine. In addition, the content of phosphatidylinositol 4,5-bisphosphate in the cytoplasmic leaflet of the plasma membrane was reduced in the presence of the ABC transporter. When heterologously expressed in Saccharomyces cerevisiae, Lr34 promoted oil body formation in a mutant defective in PL-transfer in the secretory pathway. Our results suggest that PL redistribution by Lr34 potentially affects the membrane-bound proteome and contributes to the previously reported stimuli-independent activation of biotic and abiotic stress responses and neutral lipid accumulation in transgenic Lr34-expressing barley plants." @default.
• W2895875699 created "2018-10-26" @default.
• W2895875699 creator A5021323127 @default.
• W2895875699 creator A5022657841 @default.
• W2895875699 creator A5023497262 @default.
• W2895875699 creator A5043888998 @default.
• W2895875699 creator A5074186291 @default.
• W2895875699 creator A5078737264 @default.
• W2895875699 date "2018-11-01" @default.
• W2895875699 modified "2023-10-14" @default.
• W2895875699 title "The wheat ABC transporter Lr34 modifies the lipid environment at the plasma membrane" @default.
• W2895875699 cites W1545450687 @default.
• W2895875699 cites W1568903637 @default.
• W2895875699 cites W1965146768 @default.
• W2895875699 cites W1970857342 @default.
• W2895875699 cites W1985041438 @default.
• W2895875699 cites W1985270286 @default.
• W2895875699 cites W1991307739 @default.
• W2895875699 cites W1994575756 @default.
• W2895875699 cites W1995695956 @default.
• W2895875699 cites W1996270466 @default.
• W2895875699 cites W1999850888 @default.
• W2895875699 cites W1999986525 @default.
• W2895875699 cites W2002518052 @default.
• W2895875699 cites W2005445415 @default.
• W2895875699 cites W2007498663 @default.
• W2895875699 cites W2009506963 @default.
• W2895875699 cites W2011690321 @default.
• W2895875699 cites W2022341861 @default.
• W2895875699 cites W2027953675 @default.
• W2895875699 cites W2028351657 @default.
• W2895875699 cites W2031282218 @default.
• W2895875699 cites W2035429390 @default.
• W2895875699 cites W2042915641 @default.
• W2895875699 cites W2046138985 @default.
• W2895875699 cites W2054002642 @default.
• W2895875699 cites W2077143863 @default.
• W2895875699 cites W2094616322 @default.
• W2895875699 cites W2095456641 @default.
• W2895875699 cites W2111642082 @default.
• W2895875699 cites W2129337293 @default.
• W2895875699 cites W2133531126 @default.
• W2895875699 cites W2137512452 @default.
• W2895875699 cites W2140744545 @default.
• W2895875699 cites W2144405192 @default.
• W2895875699 cites W2147018428 @default.
• W2895875699 cites W2153360043 @default.
• W2895875699 cites W2153755753 @default.
• W2895875699 cites W2158215557 @default.
• W2895875699 cites W2159891067 @default.
• W2895875699 cites W2160056675 @default.
• W2895875699 cites W2165439505 @default.
• W2895875699 cites W2166235076 @default.
• W2895875699 cites W2300552860 @default.
• W2895875699 cites W2466979535 @default.
• W2895875699 cites W4251764965 @default.
• W2895875699 doi "https://doi.org/10.1074/jbc.ra118.002532" @default.
• W2895875699 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6290163" @default.
• W2895875699 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30327425" @default.
• W2895875699 hasPublicationYear "2018" @default.
• W2895875699 type Work @default.
• W2895875699 sameAs 2895875699 @default.
• W2895875699 citedByCount "22" @default.
• W2895875699 countsByYear W28958756992019 @default.
• W2895875699 countsByYear W28958756992020 @default.
• W2895875699 countsByYear W28958756992021 @default.
• W2895875699 countsByYear W28958756992022 @default.
• W2895875699 countsByYear W28958756992023 @default.
• W2895875699 crossrefType "journal-article" @default.
• W2895875699 hasAuthorship W2895875699A5021323127 @default.
• W2895875699 hasAuthorship W2895875699A5022657841 @default.
• W2895875699 hasAuthorship W2895875699A5023497262 @default.
• W2895875699 hasAuthorship W2895875699A5043888998 @default.
• W2895875699 hasAuthorship W2895875699A5074186291 @default.
• W2895875699 hasAuthorship W2895875699A5078737264 @default.
• W2895875699 hasBestOaLocation W28958756991 @default.
• W2895875699 hasConcept C104317684 @default.
• W2895875699 hasConcept C149011108 @default.
• W2895875699 hasConcept C185592680 @default.
• W2895875699 hasConcept C190062978 @default.
• W2895875699 hasConcept C195794163 @default.
• W2895875699 hasConcept C2776909261 @default.
• W2895875699 hasConcept C2778918659 @default.
• W2895875699 hasConcept C2779637612 @default.
• W2895875699 hasConcept C36020004 @default.
• W2895875699 hasConcept C41625074 @default.
• W2895875699 hasConcept C44312359 @default.
• W2895875699 hasConcept C55493867 @default.
• W2895875699 hasConcept C62478195 @default.
• W2895875699 hasConcept C79879829 @default.
• W2895875699 hasConcept C86803240 @default.
• W2895875699 hasConcept C95444343 @default.
• W2895875699 hasConceptScore W2895875699C104317684 @default.
• W2895875699 hasConceptScore W2895875699C149011108 @default.
• W2895875699 hasConceptScore W2895875699C185592680 @default.
• W2895875699 hasConceptScore W2895875699C190062978 @default.
• W2895875699 hasConceptScore W2895875699C195794163 @default.
• W2895875699 hasConceptScore W2895875699C2776909261 @default.

• next