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- W2895876487 abstract "AD affects not only cognition but also mood and behavior, with most AD patients developing neuropsychiatric symptoms[1]. Depression is a very common clinical symptom in patients with AD, and independently affects the quality of life of the patients[2]. In AD patients, the specific cognitive domains associated with depression, and the relationship between depression and neuropsychiatric symptoms are rarely reported. Total 171 AD patients were continuously recruited in Beijing Tiantan Hospital. Patients were divided into AD with depression (AD-D) and with no depression (AD-ND) groups according to the Hamilton Depression Scale (HAMD) . Cognitive and neuropsychological symptoms were evaluated by series of rating scales for memory, execution, attention, language, visuospatial function, depression, anxiety, agitation and excessive daytime sleep. 1. Of the 171 patients with AD, 96 patients were without depression (56.1%) and 75 patients were with depression (43.9%). 2. AD-D group was younger in age of onset, and had longer disease duration (P<0.05). There were no significant differences in gender, age, and educational level between AD-D and AD-ND groups (P>0.05). 3. The total score of HAMD, anxiety/somatization, cognitive impairment, sluggish, sleep disorder and despair in group AD-D were significantly higher than those in group AD-ND (P<0.05). 4. Compared with AD-ND group, global cognitive function and multiple cognitive domains, including time orientation, location orientation, recollection, attention and computing power, language, reproduction function, visual space, execution, naming, fluency of words, AVLT instantaneous memory were all significantly worsened in AD-D group (P<0.05). 5. Anxiety, depression, indifference and agitation were all significantly compromised in AD-D group (P<0.05). 6. Daily life ability were significantly worsened in AD-D group than in AD-ND group (P<0.05). In AD patients, the incidence of depression is high, AD patients with depression were younger in age of onset and had longer disease duration, depression is correlated with the impairments of overall cognition, multiple cognitive domains and neuropsychiatric symptoms, dramatically compromising activity of daily living." @default.
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- W2895876487 date "2018-07-01" @default.
- W2895876487 modified "2023-10-12" @default.
- W2895876487 title "P4‐137: THE CLINICAL CHARACTERISTICS AND RELATED FACTORS OF ALZHEIMER'S DISEASE WITH DEPRESSION" @default.
- W2895876487 doi "https://doi.org/10.1016/j.jalz.2018.06.2541" @default.
- W2895876487 hasPublicationYear "2018" @default.
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