Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895882282> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2895882282 endingPage "1092" @default.
- W2895882282 startingPage "1080" @default.
- W2895882282 abstract "Background: Increased rate of mortality due to the development of resistance to currently available antimicrobial and anticancer agents initiated the need to develop new chemical entities for the treatment of microbial infections and cancer. Objective: The present study was aimed to synthesize and evaluate antimicrobial and anticancer activities of Schiff bases of 2-mercaptobenzimidazole. Methods: The Schiff bases of 2-mercaptobenzimidazole were synthesized from 4-(2-(1H-benzo[d]- imidazol-2-ylthio)acetamido)benzohydrazide. The synthesized compounds were evaluated for antimicrobial and anticancer activities by tube dilution method and Sulforhodamine-B (SRB) assay, respectively. Results: Compounds 8 (MICpa, an = 2.41, 1.20 µM/ml), 10 (MICse, sa = 2.50 µM/ml), 20 (MICec = 2.34 µM/ml) and 25 (MICca = 1.46 µM/ml) showed significant antimicrobial activity against tested bacterial and fungal strains and compounds 20 (IC50 = 8 µg/ml) and 23 (IC50 = 7 µg/ml) exhibited significant anticancer activity. Conclusion: In general, the synthesized derivatives exhibited moderate antimicrobial and anticancer activities. Compounds 8 and 25 having high antifungal potential among the synthesized compounds may be taken as lead molecules for the development of novel antifungal agents." @default.
- W2895882282 created "2018-10-26" @default.
- W2895882282 creator A5023924149 @default.
- W2895882282 creator A5025803819 @default.
- W2895882282 creator A5027611721 @default.
- W2895882282 creator A5062086684 @default.
- W2895882282 creator A5077343071 @default.
- W2895882282 creator A5077585324 @default.
- W2895882282 date "2019-08-21" @default.
- W2895882282 modified "2023-09-27" @default.
- W2895882282 title "2-Mercaptobenzimidazole Schiff Bases: Design, Synthesis, Antimicrobial Studies and Anticancer Activity on HCT-116 Cell Line" @default.
- W2895882282 cites W1964674056 @default.
- W2895882282 cites W1972379700 @default.
- W2895882282 cites W1994532640 @default.
- W2895882282 cites W2017706839 @default.
- W2895882282 cites W2027723770 @default.
- W2895882282 cites W2028702300 @default.
- W2895882282 cites W2046905945 @default.
- W2895882282 cites W2051818563 @default.
- W2895882282 cites W2109689528 @default.
- W2895882282 cites W2115615576 @default.
- W2895882282 doi "https://doi.org/10.2174/1389557518666181009151008" @default.
- W2895882282 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30306865" @default.
- W2895882282 hasPublicationYear "2019" @default.
- W2895882282 type Work @default.
- W2895882282 sameAs 2895882282 @default.
- W2895882282 citedByCount "20" @default.
- W2895882282 countsByYear W28958822822019 @default.
- W2895882282 countsByYear W28958822822020 @default.
- W2895882282 countsByYear W28958822822021 @default.
- W2895882282 countsByYear W28958822822022 @default.
- W2895882282 countsByYear W28958822822023 @default.
- W2895882282 crossrefType "journal-article" @default.
- W2895882282 hasAuthorship W2895882282A5023924149 @default.
- W2895882282 hasAuthorship W2895882282A5025803819 @default.
- W2895882282 hasAuthorship W2895882282A5027611721 @default.
- W2895882282 hasAuthorship W2895882282A5062086684 @default.
- W2895882282 hasAuthorship W2895882282A5077343071 @default.
- W2895882282 hasAuthorship W2895882282A5077585324 @default.
- W2895882282 hasConcept C109316439 @default.
- W2895882282 hasConcept C121608353 @default.
- W2895882282 hasConcept C126322002 @default.
- W2895882282 hasConcept C176947019 @default.
- W2895882282 hasConcept C178790620 @default.
- W2895882282 hasConcept C185592680 @default.
- W2895882282 hasConcept C202751555 @default.
- W2895882282 hasConcept C21951064 @default.
- W2895882282 hasConcept C2776074239 @default.
- W2895882282 hasConcept C2777752497 @default.
- W2895882282 hasConcept C2779548794 @default.
- W2895882282 hasConcept C2994372470 @default.
- W2895882282 hasConcept C4937899 @default.
- W2895882282 hasConcept C55493867 @default.
- W2895882282 hasConcept C71924100 @default.
- W2895882282 hasConcept C86803240 @default.
- W2895882282 hasConcept C89423630 @default.
- W2895882282 hasConcept C96232424 @default.
- W2895882282 hasConceptScore W2895882282C109316439 @default.
- W2895882282 hasConceptScore W2895882282C121608353 @default.
- W2895882282 hasConceptScore W2895882282C126322002 @default.
- W2895882282 hasConceptScore W2895882282C176947019 @default.
- W2895882282 hasConceptScore W2895882282C178790620 @default.
- W2895882282 hasConceptScore W2895882282C185592680 @default.
- W2895882282 hasConceptScore W2895882282C202751555 @default.
- W2895882282 hasConceptScore W2895882282C21951064 @default.
- W2895882282 hasConceptScore W2895882282C2776074239 @default.
- W2895882282 hasConceptScore W2895882282C2777752497 @default.
- W2895882282 hasConceptScore W2895882282C2779548794 @default.
- W2895882282 hasConceptScore W2895882282C2994372470 @default.
- W2895882282 hasConceptScore W2895882282C4937899 @default.
- W2895882282 hasConceptScore W2895882282C55493867 @default.
- W2895882282 hasConceptScore W2895882282C71924100 @default.
- W2895882282 hasConceptScore W2895882282C86803240 @default.
- W2895882282 hasConceptScore W2895882282C89423630 @default.
- W2895882282 hasConceptScore W2895882282C96232424 @default.
- W2895882282 hasIssue "13" @default.
- W2895882282 hasLocation W28958822821 @default.
- W2895882282 hasLocation W28958822822 @default.
- W2895882282 hasOpenAccess W2895882282 @default.
- W2895882282 hasPrimaryLocation W28958822821 @default.
- W2895882282 hasRelatedWork W2033349817 @default.
- W2895882282 hasRelatedWork W2097382139 @default.
- W2895882282 hasRelatedWork W2126754065 @default.
- W2895882282 hasRelatedWork W2248315687 @default.
- W2895882282 hasRelatedWork W2753184995 @default.
- W2895882282 hasRelatedWork W2895882282 @default.
- W2895882282 hasRelatedWork W2980927461 @default.
- W2895882282 hasRelatedWork W3041641488 @default.
- W2895882282 hasRelatedWork W3140569656 @default.
- W2895882282 hasRelatedWork W4205244039 @default.
- W2895882282 hasVolume "19" @default.
- W2895882282 isParatext "false" @default.
- W2895882282 isRetracted "false" @default.
- W2895882282 magId "2895882282" @default.
- W2895882282 workType "article" @default.