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- W2895885016 endingPage "1118.e17" @default.
- W2895885016 startingPage "1105" @default.
- W2895885016 abstract "Neural induction in vertebrates generates a CNS that extends the rostral-caudal length of the body. The prevailing view is that neural cells are initially induced with anterior (forebrain) identity; caudalizing signals then convert a proportion to posterior fates (spinal cord). To test this model, we used chromatin accessibility to define how cells adopt region-specific neural fates. Together with genetic and biochemical perturbations, this identified a developmental time window in which genome-wide chromatin-remodeling events preconfigure epiblast cells for neural induction. Contrary to the established model, this revealed that cells commit to a regional identity before acquiring neural identity. This “primary regionalization” allocates cells to anterior or posterior regions of the nervous system, explaining how cranial and spinal neurons are generated at appropriate axial positions. These findings prompt a revision to models of neural induction and support the proposed dual evolutionary origin of the vertebrate CNS." @default.
- W2895885016 created "2018-10-26" @default.
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- W2895885016 date "2018-11-01" @default.
- W2895885016 modified "2023-10-15" @default.
- W2895885016 title "Nervous System Regionalization Entails Axial Allocation before Neural Differentiation" @default.
- W2895885016 cites W1217705870 @default.
- W2895885016 cites W1514328067 @default.
- W2895885016 cites W1520480815 @default.
- W2895885016 cites W1668580308 @default.
- W2895885016 cites W1917459778 @default.
- W2895885016 cites W1960015501 @default.
- W2895885016 cites W1968707675 @default.
- W2895885016 cites W1971530006 @default.
- W2895885016 cites W1971912541 @default.
- W2895885016 cites W1976786814 @default.
- W2895885016 cites W1977896930 @default.
- W2895885016 cites W1978292443 @default.
- W2895885016 cites W1979594866 @default.
- W2895885016 cites W1984371544 @default.
- W2895885016 cites W1987865998 @default.
- W2895885016 cites W1989297334 @default.
- W2895885016 cites W1989769057 @default.
- W2895885016 cites W1989770606 @default.
- W2895885016 cites W2001121538 @default.
- W2895885016 cites W2014677321 @default.
- W2895885016 cites W2017690818 @default.
- W2895885016 cites W2021759395 @default.
- W2895885016 cites W2030211860 @default.
- W2895885016 cites W2032002636 @default.
- W2895885016 cites W2033201031 @default.
- W2895885016 cites W2034609545 @default.
- W2895885016 cites W2035510388 @default.
- W2895885016 cites W2036227773 @default.
- W2895885016 cites W2040029402 @default.
- W2895885016 cites W2055664397 @default.
- W2895885016 cites W2060148681 @default.
- W2895885016 cites W2066832607 @default.
- W2895885016 cites W2074229391 @default.
- W2895885016 cites W2075564625 @default.
- W2895885016 cites W2079680354 @default.
- W2895885016 cites W2080549949 @default.
- W2895885016 cites W2081518960 @default.
- W2895885016 cites W2081704147 @default.
- W2895885016 cites W2082807347 @default.
- W2895885016 cites W2087206546 @default.
- W2895885016 cites W2096528381 @default.
- W2895885016 cites W2098533907 @default.
- W2895885016 cites W2099143970 @default.
- W2895885016 cites W2102619694 @default.
- W2895885016 cites W2103412450 @default.
- W2895885016 cites W2105919528 @default.
- W2895885016 cites W2110905563 @default.
- W2895885016 cites W2113300574 @default.
- W2895885016 cites W2117757143 @default.
- W2895885016 cites W2119666376 @default.
- W2895885016 cites W2123829995 @default.
- W2895885016 cites W2128393954 @default.
- W2895885016 cites W2128665076 @default.
- W2895885016 cites W2129589628 @default.
- W2895885016 cites W2129622728 @default.
- W2895885016 cites W2130885991 @default.
- W2895885016 cites W2131478115 @default.
- W2895885016 cites W2132437126 @default.
- W2895885016 cites W2142410561 @default.
- W2895885016 cites W2146512944 @default.
- W2895885016 cites W2148708580 @default.
- W2895885016 cites W2149519740 @default.
- W2895885016 cites W2151407082 @default.
- W2895885016 cites W2153667098 @default.
- W2895885016 cites W2156659930 @default.
- W2895885016 cites W2167279371 @default.
- W2895885016 cites W2168391714 @default.
- W2895885016 cites W2170551349 @default.
- W2895885016 cites W2170830174 @default.
- W2895885016 cites W2171109270 @default.
- W2895885016 cites W2171808845 @default.
- W2895885016 cites W2179438025 @default.
- W2895885016 cites W2183822742 @default.
- W2895885016 cites W2184563578 @default.
- W2895885016 cites W2219074388 @default.
- W2895885016 cites W2231865019 @default.
- W2895885016 cites W2259938310 @default.
- W2895885016 cites W2341539131 @default.
- W2895885016 cites W2345470718 @default.
- W2895885016 cites W2514448720 @default.
- W2895885016 cites W2520953473 @default.