FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895889340> ?p ?o ?g. }

• W2895889340 endingPage "1077" @default.
• W2895889340 startingPage "1067" @default.
• W2895889340 abstract "Work with α-pyrrolidinopentiophenone (α-PVP), a second-generation synthetic cathinone, has been generally limited to the racemate. Given that with other synthetic cathinones, there are behavioral and neurochemical differences between their enantiomers, differences may also be seen with α-PVP. The present study assessed the relative contribution of each enantiomer to the aversive effects of racemic-α-PVP by comparing their ability to induce a conditioned taste avoidance. Adult male Sprague-Dawley rats were exposed every other day for four exposures to a novel saccharin solution followed immediately by an injection of 0 (saline vehicle) or 1.5, 3, or 6 mg/kg of S-, R-, or racemic-α-PVP (IP). On alternating days, all subjects were given access to water to assess any unconditioned effects of α-PVP on general fluid consumption. Rats injected with the racemate and S-isomer of α-PVP displayed avoidance of the drug-associated saccharin solution, although this avoidance was dose-dependent only for the subjects injected with the racemate. There was no evidence of taste avoidance in animals injected with the R-enantiomer at any dose tested. Animals injected with 3 mg/kg racemic-α-PVP did not differ in avoidance from those treated with 1.5 mg/kg of the S-enantiomer, but subjects treated with 6 mg/kg racemic-α-PVP displayed a significantly stronger avoidance than those treated with 3 mg/kg S-α-PVP. The present work suggests that the aversive effects of racemic α-PVP are mediated primarily by its S-isomer. The fact that at the highest dose tested (6 mg/kg), the racemate induces an avoidance greater than the simple additive effects of the S- and R-isomers (at 3 mg/kg) suggests that while the R-isomer may not induce taste avoidance at this dose, it may interact synergistically with the S-isomer in mediating the effects of the racemic mixture. These results were discussed in terms of similar effects with other behavioral and physiological endpoints reported with a number of psychostimulants and suggest that the enantiomers of α-PVP are an important variable in characterizing its behavioral effects." @default.
• W2895889340 created "2018-10-26" @default.
• W2895889340 creator A5004869831 @default.
• W2895889340 creator A5019145772 @default.
• W2895889340 creator A5028434959 @default.
• W2895889340 creator A5047732167 @default.
• W2895889340 creator A5060070540 @default.
• W2895889340 creator A5060559604 @default.
• W2895889340 creator A5060799349 @default.
• W2895889340 creator A5072565784 @default.
• W2895889340 creator A5081270899 @default.
• W2895889340 date "2018-10-17" @default.
• W2895889340 modified "2023-09-29" @default.
• W2895889340 title "Stereoselective effects of the second-generation synthetic cathinone α-pyrrolidinopentiophenone (α-PVP): assessments of conditioned taste avoidance in rats" @default.
• W2895889340 cites W1007713468 @default.
• W2895889340 cites W1555375083 @default.
• W2895889340 cites W1948647813 @default.
• W2895889340 cites W1964890792 @default.
• W2895889340 cites W1966001244 @default.
• W2895889340 cites W1981039835 @default.
• W2895889340 cites W1981310862 @default.
• W2895889340 cites W1993573489 @default.
• W2895889340 cites W2003492082 @default.
• W2895889340 cites W2016305787 @default.
• W2895889340 cites W2017839960 @default.
• W2895889340 cites W2018205207 @default.
• W2895889340 cites W2020351247 @default.
• W2895889340 cites W2020356423 @default.
• W2895889340 cites W2023623892 @default.
• W2895889340 cites W2024039290 @default.
• W2895889340 cites W2024807216 @default.
• W2895889340 cites W2033865036 @default.
• W2895889340 cites W2034060963 @default.
• W2895889340 cites W2040542735 @default.
• W2895889340 cites W2049396251 @default.
• W2895889340 cites W2051202848 @default.
• W2895889340 cites W2054019430 @default.
• W2895889340 cites W2061175699 @default.
• W2895889340 cites W2072698517 @default.
• W2895889340 cites W2075913599 @default.
• W2895889340 cites W2080294650 @default.
• W2895889340 cites W2082269063 @default.
• W2895889340 cites W2083229818 @default.
• W2895889340 cites W2085461481 @default.
• W2895889340 cites W2085866328 @default.
• W2895889340 cites W2094257063 @default.
• W2895889340 cites W2105222863 @default.
• W2895889340 cites W2108536425 @default.
• W2895889340 cites W2118107039 @default.
• W2895889340 cites W2140559913 @default.
• W2895889340 cites W2150506554 @default.
• W2895889340 cites W2167085007 @default.
• W2895889340 cites W2167766292 @default.
• W2895889340 cites W2193277276 @default.
• W2895889340 cites W2343159205 @default.
• W2895889340 cites W2406223204 @default.
• W2895889340 cites W2412911135 @default.
• W2895889340 cites W2414766432 @default.
• W2895889340 cites W2439941125 @default.
• W2895889340 cites W2475907492 @default.
• W2895889340 cites W2484700864 @default.
• W2895889340 cites W2551821836 @default.
• W2895889340 cites W2559340240 @default.
• W2895889340 cites W2607293421 @default.
• W2895889340 cites W2620843193 @default.
• W2895889340 cites W2762169497 @default.
• W2895889340 cites W2951640374 @default.
• W2895889340 doi "https://doi.org/10.1007/s00213-018-5070-x" @default.
• W2895889340 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8328279" @default.
• W2895889340 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30334086" @default.
• W2895889340 hasPublicationYear "2018" @default.
• W2895889340 type Work @default.
• W2895889340 sameAs 2895889340 @default.
• W2895889340 citedByCount "11" @default.
• W2895889340 countsByYear W28958893402019 @default.
• W2895889340 countsByYear W28958893402020 @default.
• W2895889340 countsByYear W28958893402021 @default.
• W2895889340 countsByYear W28958893402022 @default.
• W2895889340 countsByYear W28958893402023 @default.
• W2895889340 crossrefType "journal-article" @default.
• W2895889340 hasAuthorship W2895889340A5004869831 @default.
• W2895889340 hasAuthorship W2895889340A5019145772 @default.
• W2895889340 hasAuthorship W2895889340A5028434959 @default.
• W2895889340 hasAuthorship W2895889340A5047732167 @default.
• W2895889340 hasAuthorship W2895889340A5060070540 @default.
• W2895889340 hasAuthorship W2895889340A5060559604 @default.
• W2895889340 hasAuthorship W2895889340A5060799349 @default.
• W2895889340 hasAuthorship W2895889340A5072565784 @default.
• W2895889340 hasAuthorship W2895889340A5081270899 @default.
• W2895889340 hasBestOaLocation W28958893402 @default.
• W2895889340 hasConcept C134018914 @default.
• W2895889340 hasConcept C161790260 @default.
• W2895889340 hasConcept C164742699 @default.
• W2895889340 hasConcept C181647583 @default.
• W2895889340 hasConcept C185592680 @default.
• W2895889340 hasConcept C25876315 @default.
• W2895889340 hasConcept C2777397205 @default.
• W2895889340 hasConcept C2779147919 @default.

• next