Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895890381> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2895890381 abstract "Intracellular accumulation of aggregated hyperphosphorylated tau protein is a neuropathological hallmark of neurodegenerative proteinopathies, such as Alzheimer's disease and primary tauopathies. Understanding how different tau variants lead to disease pathogenesis will allow us to mechanistically elucidate molecular properties and differential etiologies of wild type and tauopathy-associated variants. Currently there are several transgenic mouse models that can recapitulate substantial aspects of tauopathy. Though most of these faithfully recreate age-progressive hyperphosphorylation of tau, many do not show neurodegenerative changes, behavioral abnormalities or frank neurofibrillary tangles (NFT). While it is possible that these models may be tracking only the molecular properties of a particular tau variant, it is entirely possible that the strain of the mouse, its immune phenotype, the promoter used as well as the tissue distribution of the transgene can lead to these differential phenotypes. To allow us to study the molecular and physiological properties of tauopathy-associated tau variants on a standardized genetic background, we performed neonatal intraceberoventricular injections of recombinant adeno-associated viruses overexpressing different tau mutants in wild type mice. This results in, what we have previously described as, ‘somatic transgenesis’ models of tauopathy. Mice expressing different tau variants were aged and extensively characterized using behavioral and neuropathological parameters. We find that CNS targeted expression of wild type and several FTD-associated mutants (such as P301L and P301S) result in extensive age-progressive tau hyperphosphorylation. However, only the P301L tau expressing mice develop NFT by 9 months of age. In contrast, a Pick's disease associated variant leads to NFT by 3 months of age and a mouse model which expresses both P301L tau and the PiD variant leads to extensive neurodegenerative features, behavioral abnormalities and NFT by 3 months of age. We report various tauopathy models that allow us to molecularly phenotype different tauopathy-associated tau variants. These somatic transgenesis models allow us an alternative platform for cost-effective and rapid phenotyping of tau variants. These models can also be used to test different therapeutic interventions based on the particular molecular phenotype being targeted, i.e., tau phosphorylation, neurodegeneration, behavioral abnormalities and/or NFT." @default.
- W2895890381 created "2018-10-26" @default.
- W2895890381 creator A5004977571 @default.
- W2895890381 creator A5005020048 @default.
- W2895890381 creator A5008162674 @default.
- W2895890381 creator A5011965074 @default.
- W2895890381 creator A5048465733 @default.
- W2895890381 creator A5048672759 @default.
- W2895890381 creator A5050903223 @default.
- W2895890381 creator A5057702915 @default.
- W2895890381 creator A5058688886 @default.
- W2895890381 creator A5068446551 @default.
- W2895890381 creator A5079182304 @default.
- W2895890381 creator A5082320489 @default.
- W2895890381 date "2018-07-01" @default.
- W2895890381 modified "2023-10-16" @default.
- W2895890381 title "P3‐091: MODELING TAUOPATHY USING AAV‐MEDIATED SOMATIC BRAIN TRANSGENESIS" @default.
- W2895890381 doi "https://doi.org/10.1016/j.jalz.2018.06.1447" @default.
- W2895890381 hasPublicationYear "2018" @default.
- W2895890381 type Work @default.
- W2895890381 sameAs 2895890381 @default.
- W2895890381 citedByCount "0" @default.
- W2895890381 crossrefType "journal-article" @default.
- W2895890381 hasAuthorship W2895890381A5004977571 @default.
- W2895890381 hasAuthorship W2895890381A5005020048 @default.
- W2895890381 hasAuthorship W2895890381A5008162674 @default.
- W2895890381 hasAuthorship W2895890381A5011965074 @default.
- W2895890381 hasAuthorship W2895890381A5048465733 @default.
- W2895890381 hasAuthorship W2895890381A5048672759 @default.
- W2895890381 hasAuthorship W2895890381A5050903223 @default.
- W2895890381 hasAuthorship W2895890381A5057702915 @default.
- W2895890381 hasAuthorship W2895890381A5058688886 @default.
- W2895890381 hasAuthorship W2895890381A5068446551 @default.
- W2895890381 hasAuthorship W2895890381A5079182304 @default.
- W2895890381 hasAuthorship W2895890381A5082320489 @default.
- W2895890381 hasConcept C102230213 @default.
- W2895890381 hasConcept C104317684 @default.
- W2895890381 hasConcept C127716648 @default.
- W2895890381 hasConcept C141035611 @default.
- W2895890381 hasConcept C142724271 @default.
- W2895890381 hasConcept C169760540 @default.
- W2895890381 hasConcept C184235292 @default.
- W2895890381 hasConcept C2776925932 @default.
- W2895890381 hasConcept C2777739294 @default.
- W2895890381 hasConcept C2778198054 @default.
- W2895890381 hasConcept C2778670691 @default.
- W2895890381 hasConcept C2779134260 @default.
- W2895890381 hasConcept C2779390119 @default.
- W2895890381 hasConcept C502032728 @default.
- W2895890381 hasConcept C519853106 @default.
- W2895890381 hasConcept C54355233 @default.
- W2895890381 hasConcept C71924100 @default.
- W2895890381 hasConcept C73247094 @default.
- W2895890381 hasConcept C86803240 @default.
- W2895890381 hasConcept C87073359 @default.
- W2895890381 hasConceptScore W2895890381C102230213 @default.
- W2895890381 hasConceptScore W2895890381C104317684 @default.
- W2895890381 hasConceptScore W2895890381C127716648 @default.
- W2895890381 hasConceptScore W2895890381C141035611 @default.
- W2895890381 hasConceptScore W2895890381C142724271 @default.
- W2895890381 hasConceptScore W2895890381C169760540 @default.
- W2895890381 hasConceptScore W2895890381C184235292 @default.
- W2895890381 hasConceptScore W2895890381C2776925932 @default.
- W2895890381 hasConceptScore W2895890381C2777739294 @default.
- W2895890381 hasConceptScore W2895890381C2778198054 @default.
- W2895890381 hasConceptScore W2895890381C2778670691 @default.
- W2895890381 hasConceptScore W2895890381C2779134260 @default.
- W2895890381 hasConceptScore W2895890381C2779390119 @default.
- W2895890381 hasConceptScore W2895890381C502032728 @default.
- W2895890381 hasConceptScore W2895890381C519853106 @default.
- W2895890381 hasConceptScore W2895890381C54355233 @default.
- W2895890381 hasConceptScore W2895890381C71924100 @default.
- W2895890381 hasConceptScore W2895890381C73247094 @default.
- W2895890381 hasConceptScore W2895890381C86803240 @default.
- W2895890381 hasConceptScore W2895890381C87073359 @default.
- W2895890381 hasIssue "7S_Part_20" @default.
- W2895890381 hasLocation W28958903811 @default.
- W2895890381 hasOpenAccess W2895890381 @default.
- W2895890381 hasPrimaryLocation W28958903811 @default.
- W2895890381 hasRelatedWork W2004465879 @default.
- W2895890381 hasRelatedWork W2022083204 @default.
- W2895890381 hasRelatedWork W2071580328 @default.
- W2895890381 hasRelatedWork W2117071840 @default.
- W2895890381 hasRelatedWork W2141490098 @default.
- W2895890381 hasRelatedWork W2404733949 @default.
- W2895890381 hasRelatedWork W2983621322 @default.
- W2895890381 hasRelatedWork W3000446097 @default.
- W2895890381 hasRelatedWork W3111502935 @default.
- W2895890381 hasRelatedWork W4376108338 @default.
- W2895890381 hasVolume "14" @default.
- W2895890381 isParatext "false" @default.
- W2895890381 isRetracted "false" @default.
- W2895890381 magId "2895890381" @default.
- W2895890381 workType "article" @default.