FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895892165> ?p ?o ?g. }

• W2895892165 endingPage "e306" @default.
• W2895892165 startingPage "e306" @default.
• W2895892165 abstract "To evaluate correlation of volumetric staging, hematologic indices and TNM staging with efficacy of radiotherapy (RT) and chemoradiation (ChRT) for tongue cancer. The study included 61 patients (47 male, 14 female) diagnosed with tongue cancer (squamous cell carcinoma in 97% cases) aged 40-83 (median 59, mean 60) treated by RT/ChRT. Regional lymph nodes were involved in 70% of patients. Inclusion criteria were: RT or ChRT as radical therapy and no other forms of therapy. In 10 cases (16%) RT was primary choice of radical treatment. The remaining patients were disqualified from surgical approach due to comorbidities (28%), extent of the disease (39%), localization of primary lesion (10%) or lack of consent (7%). The TNM stage varied from I to IVb. Tumor and nodal volume ranged from 3.7 to 113.1cm3 and 0 to 46.1cm3, respectively. Total tumor and nodal volumes combined (GTV) were further divided into 3 risk groups with cutoff values of 15 and 70cm3. Chemotherapy (cisplatin-based) was applied in 14 patients. Total dose of 60 to 74Gy in fractions of 1.1 to 2.2Gy (combined with brachytherapy boost of 15-18Gy in 6 cases) was delivered. Blood tests were taken before RT. Statistical analysis included log-rank test, Kaplan Meier estimator, Cox proportional hazards model and Spearman’s rho. Follow-up ranged from 0 to 130 months (median 14.6 months, 4 cases without follow-up). 5-year overall survival (OS) was 37.5%. Progression of the disease was noted in 24 patients and 1-year progression free survival (PFS) defined as local, nodal and distant control was 48%. GTV divided into risk groups correlated with 1-year PFS, 3-year OS and 5-year OS (p values of 0.04, 0.04 and 0.05, respectively). Absolute values of GTV volumes correlated with 1-year PFS and 3-year OS. For TNM stage, both considered as separate groups and when comparing 0-III vs IVa-IVc stage patients no correlations with RT results were found. Neutrophils-to-lymphocyte ratio above upper or below lower quartile and higher values of hemoglobin count correlated with better 1-year PFS. There was a negative correlation between neutrophil level and treatment results. Present results suggest that for tongue cancer patients, TNM stage poorly correlates with results of RT and its prognostic value is inferior to GTV-based volumetric stage. Volumetric staging alone or combined with hematologic indices seems to be more optimal staging system than TNM." @default.
• W2895892165 created "2018-10-26" @default.
• W2895892165 creator A5059158049 @default.
• W2895892165 creator A5063514844 @default.
• W2895892165 creator A5085223650 @default.
• W2895892165 date "2018-11-01" @default.
• W2895892165 modified "2023-10-01" @default.
• W2895892165 title "Value of Volumetric Staging and Hematologic Indices As an Alternative to the TNM Staging in Radiation Therapy for Tongue Cancer" @default.
• W2895892165 doi "https://doi.org/10.1016/j.ijrobp.2018.07.960" @default.
• W2895892165 hasPublicationYear "2018" @default.
• W2895892165 type Work @default.
• W2895892165 sameAs 2895892165 @default.
• W2895892165 citedByCount "0" @default.
• W2895892165 crossrefType "journal-article" @default.
• W2895892165 hasAuthorship W2895892165A5059158049 @default.
• W2895892165 hasAuthorship W2895892165A5063514844 @default.
• W2895892165 hasAuthorship W2895892165A5085223650 @default.
• W2895892165 hasBestOaLocation W28958921651 @default.
• W2895892165 hasConcept C10515644 @default.
• W2895892165 hasConcept C121608353 @default.
• W2895892165 hasConcept C126322002 @default.
• W2895892165 hasConcept C141071460 @default.
• W2895892165 hasConcept C142724271 @default.
• W2895892165 hasConcept C146357865 @default.
• W2895892165 hasConcept C151730666 @default.
• W2895892165 hasConcept C2777416452 @default.
• W2895892165 hasConcept C2778474501 @default.
• W2895892165 hasConcept C2779744641 @default.
• W2895892165 hasConcept C2780849966 @default.
• W2895892165 hasConcept C2989005 @default.
• W2895892165 hasConcept C50382708 @default.
• W2895892165 hasConcept C509974204 @default.
• W2895892165 hasConcept C71924100 @default.
• W2895892165 hasConcept C86803240 @default.
• W2895892165 hasConceptScore W2895892165C10515644 @default.
• W2895892165 hasConceptScore W2895892165C121608353 @default.
• W2895892165 hasConceptScore W2895892165C126322002 @default.
• W2895892165 hasConceptScore W2895892165C141071460 @default.
• W2895892165 hasConceptScore W2895892165C142724271 @default.
• W2895892165 hasConceptScore W2895892165C146357865 @default.
• W2895892165 hasConceptScore W2895892165C151730666 @default.
• W2895892165 hasConceptScore W2895892165C2777416452 @default.
• W2895892165 hasConceptScore W2895892165C2778474501 @default.
• W2895892165 hasConceptScore W2895892165C2779744641 @default.
• W2895892165 hasConceptScore W2895892165C2780849966 @default.
• W2895892165 hasConceptScore W2895892165C2989005 @default.
• W2895892165 hasConceptScore W2895892165C50382708 @default.
• W2895892165 hasConceptScore W2895892165C509974204 @default.
• W2895892165 hasConceptScore W2895892165C71924100 @default.
• W2895892165 hasConceptScore W2895892165C86803240 @default.
• W2895892165 hasIssue "3" @default.
• W2895892165 hasLocation W28958921651 @default.
• W2895892165 hasOpenAccess W2895892165 @default.
• W2895892165 hasPrimaryLocation W28958921651 @default.
• W2895892165 hasRelatedWork W2025438229 @default.
• W2895892165 hasRelatedWork W2064428643 @default.
• W2895892165 hasRelatedWork W2170619751 @default.
• W2895892165 hasRelatedWork W2361165600 @default.
• W2895892165 hasRelatedWork W2361418279 @default.
• W2895892165 hasRelatedWork W2383944262 @default.
• W2895892165 hasRelatedWork W2408168761 @default.
• W2895892165 hasRelatedWork W2915474482 @default.
• W2895892165 hasRelatedWork W3032413756 @default.
• W2895892165 hasRelatedWork W4200625661 @default.
• W2895892165 hasVolume "102" @default.
• W2895892165 isParatext "false" @default.
• W2895892165 isRetracted "false" @default.
• W2895892165 magId "2895892165" @default.
• W2895892165 workType "article" @default.