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- W2895893263 abstract "Abstract Objectives The aim of this study was to evaluate the efficacy of hematoporphyrin monomethyl ether (HMME)-mediated sonodynamic therapy (SDT) on porphyromonas gingivalis (Pg) and experimental periodontal disease in rats with diabetes. Methods Pg (ATCC 33277) was used in this study. Colony forming unit assay was performed to evaluate the bactericidal effect with different ultrasonic time and HMME concentration parameters. The intracellular content of reactive oxygen species (ROS) was detected. 36 female Wistar rats weighing 200 to 250 g were randomly divided into two groups: non-diabetic (ND; n=18) and diabetic (D; n=18). Periodontal disease was induced by orally administering Pg and placing ligatures around the cervix of the first maxillary molar. Streptozotocin (STZ) was injected intraperitoneally (60 mg/kg) to establish the diabetic rat model. After 4 weeks, the rats in each group (ND and D groups) were received one of three treatments (6 rats per treatment): irrigation with sterile saline solution (control group); scaling and root planing (SRP) (SRP group); hypodermic injection of 40 μg/mL HMME with 3 W/cm2 low-intensity ultrasound irradiation every other day (1 MHz, 600 s) (SRP+SDT group). All rats were euthanized at 10 days postoperatively. The maxilla was taken for histological examination. The distance between the cementoenamel junction (CEJ) and the alveolar bone crest (ABC) was measured to access the level of alveolar bone. Results In SDT treatment, higher HMME concentration and longer ultrasound irradiation time induced more CFU reduction. 4.7 lg reduction in CFU, When Pg was treated with ultrasound (3 W/cm2 for 10 min) at 40 μg/mL HMME concentration (P Conclusions SDT was an effective adjuvant therapy to SRP on induced periodontal disease and diabetes mellitus in rats." @default.
- W2895893263 created "2018-10-26" @default.
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- W2895893263 date "2018-10-23" @default.
- W2895893263 modified "2023-09-27" @default.
- W2895893263 title "Sonodynamic therapy as an adjunctive treatment on porphyromonas gingivalis induced periodontitis in rats with diabetes" @default.
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