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• W2895895168 abstract "The disassembly of eukaryotic replisome during replication termination is mediated by CRL-dependent poly-ubiquitylation of Mcm7 and p97 segregase. The replisome also disassembles at stalled or collapsed replication forks under certain stress conditions, but the underlying mechanism is poorly understood. Here, we discovered a novel pathway driving stepwise disassembly of the replisome at stalled replication forks after forced entry into M-phase using Xenopus egg extracts. This pathway was dependent on M-CDK activity and K48- and K63-linked poly-ubiquitylation but not on CRL and p97, which is different from known pathways. Furthermore, this pathway could not disassemble converged replisomes whose Mcm7 subunit had been poly-ubiquitylated without p97. These results suggest that there is a distinctive pathway for replisome disassembly when stalled replication forks persist into M-phase." @default.
• W2895895168 created "2018-10-26" @default.
• W2895895168 creator A5063570309 @default.
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• W2895895168 date "2018-11-01" @default.
• W2895895168 modified "2023-10-15" @default.
• W2895895168 title "Mitotic entry drives replisome disassembly at stalled replication forks" @default.
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• W2895895168 doi "https://doi.org/10.1016/j.bbrc.2018.10.064" @default.
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