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- W2895897133 abstract "Now FDA-approved in the treatment of over ten malignancies, checkpoint blockade agents have transformed the treatment of cancer. These agents work by inhibiting the PD-1/PD-L1 interaction between cytotoxic T cells and tumor cells, an interaction which promotes immune evasion. PD-L1 expression levels by tumor cells, as assessed by tissue biopsy, is currently the most well-validated and clinically used predictive biomarker of response to checkpoint blockade agents (1,2). However, PD-L1 level is known to be an imperfect biomarker, and some FDA approvals do not set a PD-L1 expression level threshold to determine patient candidacy for checkpoint blockade." @default.
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- W2895897133 date "2018-11-01" @default.
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- W2895897133 title "Non-invasive assessment of tumor PD-L1 status with circulating tumor cells" @default.
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- W2895897133 doi "https://doi.org/10.21037/atm.2018.10.09" @default.
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