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- W2895904854 abstract "Taking advantage of the nucleophile-sensitive ester link of oxime resin, a novel synthetic strategy was applied to the first synthesis of a type of cyclic peptides known as pseudacyclins A–E. The endocyclic ornithine side-chain part was incorporated by an on-resin acid-catalyzed concomitant cyclization-cleavage reaction after a selective deprotection of orthogonally protected ornithine. The synthetic methodology gives high macrocyclization yields and low oligomerization side-products. The combination used of solid-phase/solution-phase strategy was efficient to prepare pseudacyclins and could prove useful to prepare other natural cycle-tail peptides." @default.
- W2895904854 created "2018-10-26" @default.
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- W2895904854 date "2018-11-01" @default.
- W2895904854 modified "2023-09-27" @default.
- W2895904854 title "Total synthesis of pseudacyclins A–E by an on-resin head-to-side chain concomitant cyclization-cleavage reaction" @default.
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- W2895904854 doi "https://doi.org/10.1016/j.tetlet.2018.10.025" @default.
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