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• W2895905660 abstract "Age effects on white matter (WM) microstructure and concomitant decline in executive function (EF) are well documented from cross-sectional studies. However, longitudinal studies exploring the relationships between interindividual differences in the rate of WM microstructure decline and EF are less common. Furthermore, the effects of sex on such trajectories are not well understood. We examined sex differences in the rates of change (ROC) in DTI metrics of WM microstructure and EF. Participants included 193 males and 239 females (mean baseline age 73.0 years) from the Baltimore Longitudinal Study of Aging who were repeatedly tested over a mean follow-up interval of 4.7 years (mean assessments 2.9). WM microstructure was measured as fractional anisotropy (FA) and mean diffusivity (MD) from DTI. EF was measured using the Trail Making Test Part B and the Digits Backward task. Linear mixed effects models assessed change in WM microstructure and EF and evaluated sex differences. The associations between interindividual ROC in WM microstructure and EF were assessed for men and women separately. At baseline there were sex differences in multiple WM regions with higher FA and lower MD in men (p<0.01). There were significant decreases in FA and increases in MD in multiple WM structures, however, there were no sex differences in these ROC except for steeper increases in MD in women within the corpus callosum (genu) (p<0.001). There were no sex differences at baseline or in ROC for EF. In men, ROC in EF was positively associated with ROC in FA in the sagittal stratum and corpus callosum (body) and negatively associated to ROC in MD within the inferior fronto-occipital fasciculus, sagittal stratum, and the anterior and superior corona radiata (p<0.01). In women, ROC in EF were positively associated with ROC in FA in the corpus callosum (body) and negatively associated with MD in the posterior corona radiata (p<0.01). While there were no sex differences in the ROC in WM microstructure or EF, there were distinct sex differences in the WM regions associated with EF. This suggests there may be key sex differences in the neurological substrates driving age-related cognitive decline." @default.
• W2895905660 created "2018-10-26" @default.
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• W2895905660 date "2018-07-01" @default.
• W2895905660 modified "2023-10-16" @default.
• W2895905660 title "P2‐412: SEX DIFFERENCES IN WHITE MATTER MICROSTRUCTURE AND ITS EFFECTS ON EXECUTIVE FUNCTION: RESULTS FROM THE BALTIMORE LONGITUDINAL STUDY OF AGING" @default.
• W2895905660 doi "https://doi.org/10.1016/j.jalz.2018.06.1104" @default.
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